Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus

Autor: Zhifeng Li, Jianli Hu, Changjun Bao, Chengfeng Gao, Nan Zhang, Carol J. Cardona, Zheng Xing

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging phlebovirus that causes a hemorrhagic fever known as the severe fever with thrombocytopenia syndrome (SFTS). Inflammasomes are a molecular platform that are assembled t

Externí odkaz: https://doaj.org/article/8aa5229228ef43c5810bfa90d8d61e09

Intrinsic features of Zika Virus non-structural proteins NS2A and NS4A in the regulation of viral replication.

Autor: Yufeng Yu, Chengfeng Gao, Chunxia Wen, Peng Zou, Xian Qi, Carol J Cardona, Zheng Xing

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010366 (2022)

Zika virus (ZIKV) is a mosquito-borne flavivirus and can cause neurodevelopmental disorders in fetus. As a neurotropic virus, ZIKV persistently infects neural tissues during pregnancy but the viral pathogenesis remains largely unknown. ZIKV has a pos

Externí odkaz: https://doaj.org/article/a6351f353c20453b9b76777844b180be

Research on Discharging Current Distribution of Grounding Electrodes

Autor: Zhanlong Zhang, Yihua Dan, Jing Zou, Guohua Liu, Chengfeng Gao, Yiqiao Li

Publikováno v: IEEE Access, Vol 7, Pp 59287-59298 (2019)

Grounding electrodes with good current discharging performance can ensure the reliability of power system security. Discharging current is not only the reason for accelerating the corrosion, but also the key indicator of the grounding electrodes' gro

Externí odkaz: https://doaj.org/article/49ab3818cc9643e69de1cd5d435cd38a

The challenge of mapping the human connectome based on diffusion tractography

Autor: Klaus H. Maier-Hein, Peter F. Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E. Reddick, John O. Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, Renjie He, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J. Omar Ocegueda González, Michael Paquette, Samuel St-Jean, Gabriel Girard, François Rheault, Jasmeen Sidhu, Chantal M. W. Tax, Fenghua Guo, Hamed Y. Mesri, Szabolcs Dávid, Martijn Froeling, Anneriet M. Heemskerk, Alexander Leemans, Arnaud Boré, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R. Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auría, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H. Ertan Cetingul, Benjamin L. Odry, Boris Mailhe, Mariappan S. Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E. Villalon-Reina, Justin Galvis, Paul M. Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell’Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B. Dyrby, Tim Holland-Letz, Claus C. Hilgetag, Bram Stieltjes, Maxime Descoteaux

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.

Externí odkaz: https://doaj.org/article/67c5930443f649148e606525891370e8

Fludarabine Inhibits Infection of Zika Virus, SFTS Phlebovirus, and Enterovirus A71

Autor: Chengfeng Gao, Chunxia Wen, Zhifeng Li, Shuhan Lin, Shu Gao, Haida Ding, Peng Zou, Zheng Xing, Yufeng Yu

Publikováno v: Viruses, Vol 13, Iss 5, p 774 (2021)

Viral infections are one of the leading causes in human mortality and disease. Broad-spectrum antiviral drugs are a powerful weapon against new and re-emerging viruses. However, viral resistance to existing broad-spectrum antivirals remains a challen

Externí odkaz: https://doaj.org/article/92696bb7dc9a47a8a734c875cc7073cf