Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chengcheng Meng"'
Autor:
Iqbal Mahmud, Guimei Tian, Jia Wang, Tarun E. Hutchinson, Brandon J. Kim, Nikee Awasthee, Seth Hale, Chengcheng Meng, Allison Moore, Liming Zhao, Jessica E. Lewis, Aaron Waddell, Shangtao Wu, Julia M. Steger, McKenzie L. Lydon, Aaron Chait, Lisa Y. Zhao, Haocheng Ding, Jian-Liang Li, Hamsa Thayele Purayil, Zhiguang Huo, Yehia Daaka, Timothy J. Garrett, Daiqing Liao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly understood. Using integrated transcrip
Externí odkaz:
https://doaj.org/article/7bed513e4be84384b1eeaf5eada78cd4
Autor:
Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, Abigail E. Case, Wei Ni, Swati Garg, Martin Sattler, Abdel Kareem Azab, Jennifer Sun, Barbara Muz, Dana Sanchez, Anthia Toure, Richard M. Stone, Ilene Galinsky, Eric Winer, Scott Gleim, Sofia Gkountela, Alexia Kedves, Edmund Harrington, Tinya Abrams, Thomas Zoller, Andrea Vaupel, Paul Manley, Michael Faller, BoYee Chung, Xin Chen, Philipp Busenhart, Christine Stephan, Keith Calkins, Debora Bonenfant, Claudio R. Thoma, William Forrester, James D. Griffin
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-10 (2022)
Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule
Externí odkaz:
https://doaj.org/article/3c275c0fed054a4ca5adaa6cd08da2ce
Autor:
Baoyang Ruan, Xiaorong Zhang, Chengcheng Zhang, Pengyu Du, Chengcheng Meng, Mengjiao Guo, Yantao Wu, Yongzhong Cao
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Thermostable Newcastle disease virus (NDV) vaccines have been widely used in areas where a “cold-chain” is not reliable. However, the molecular mechanism of NDV thermostability remains poorly understood. In this work, we constructed chimeric viru
Externí odkaz:
https://doaj.org/article/a642d525c172415280784bd6d994aea3
Autor:
Jing Yang, Ellen L. Weisberg, Shuang Qi, Wei Ni, Husheng Mei, Zuowei Wang, Chengcheng Meng, Shengzhe Zhang, Mingqi Hou, Ziping Qi, Aoli Wang, Yunyun Jiang, Zongru Jiang, Tao Huang, Qingwang Liu, Robert S. Magin, Laura Doherty, Wenchao Wang, Jing Liu, Sara J. Buhrlage, Qingsong Liu, James D. Griffin
Publikováno v:
Leukemia. 36:1048-1057
Activating mutations in EZH2, the catalytic component of PRC2, promote cell proliferation, tumorigenesis, and metastasis through enzymatic or non-enzymatic activity. The EZH2-Y641 gain-of-function mutation is one of the most significant in diffuse la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e01436e5d7e312a5193dca44eff240
https://doi.org/10.1038/s41375-021-01494-w
https://doi.org/10.1038/s41375-021-01494-w
Autor:
RuthMabel Boytz, Mikołaj Słabicki, Sita Ramaswamy, J. J. Patten, Charles Zou, Chengcheng Meng, Brett L. Hurst, Jinhua Wang, Radosław P. Nowak, Priscilla L. Yang, Martin Sattler, Richard M. Stone, James D. Griffin, Nathanael S. Gray, Suryaram Gummuluru, Robert A. Davey, Ellen Weisberg
Publikováno v:
Journal of Medical Virology. 95
Coronavirus disease 2019 (COVID-19) remains a major public health concern, and vaccine unavailability, hesitancy, or failure underscore the need for discovery of efficacious antiviral drug therapies. Numerous approved drugs target protein kinases ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af08c3a93ccdb0fe6c8c73753765c85b
https://doi.org/10.1002/jmv.28157
https://doi.org/10.1002/jmv.28157
Autor:
Wai Cheung Chan, Lucia Cabal-Hierro, James D. Griffin, Sara J. Buhrlage, Jing Yang, Jarrod A. Marto, Eric P. Winer, Robert S. Magin, Ellen Weisberg, Bin Hu, Xiaoxi Liu, Shengzhe Zhang, Chengcheng Meng, Richard Stone, Laura M. Doherty, Martin Sattler, Ilaria Lamberto, Nathan J. Schauer
Publikováno v:
Leukemia. 36:210-220
Mutations in the Janus Kinase 2 (JAK2) gene resulting in constitutive kinase activation represent the most common genetic event in myeloproliferative neoplasms (MPN), a group of diseases involving overproduction of one or more kinds of blood cells, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2f2b6494458ce8506a16b759c1bd2a6
https://doi.org/10.1038/s41375-021-01336-9
https://doi.org/10.1038/s41375-021-01336-9
Autor:
Aine Knott, Chengcheng Meng, Abigail E Case, Prafulla C. Gokhale, Alex E. Pozhitkov, Ruben D. Carrasco, Yin P Hung, Moshe Lapidot, James D. Griffin, Sunil Sharma, Martin Sattler, Raphael Bueno, Klaus Podar, David A. Frank, Sarah R. Walker, Srinivas Vinod Saladi, Swati Garg, Ellen Weisberg, Ravi Salgia, Prakash Kulkarni, Wei Ni
Publikováno v:
British Journal of Cancer
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b722840cbc4dafad4ce4ec4a441cbfc
http://europepmc.org/articles/PMC8368004
http://europepmc.org/articles/PMC8368004
Publikováno v:
Neurocomputing. 432:1-9
This paper addresses the surge speed tracking of an unmanned surface vehicle (USV) subject to unknown surge and propeller dynamics. A two-phase on-line identification and control strategy is proposed for designing a speed tracking controller without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3cbe4b56758b45ee3ebc06c8e4c3149
https://doi.org/10.1016/j.neucom.2020.12.036
https://doi.org/10.1016/j.neucom.2020.12.036
Autor:
Ilaria Lamberto, Sophia Adamia, Abigail E Case, Sara J. Buhrlage, Jinhua Wang, Jing Yang, James D. Griffin, Martin Sattler, Suiyang Liu, Nathanael S. Gray, Chengcheng Meng, Ellen Weisberg, Robert S. Magin, Richard Stone
Publikováno v:
British Journal of Cancer
Background There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2cdb0dd723d10b5f3fe493e76d567
http://europepmc.org/articles/PMC7156412
http://europepmc.org/articles/PMC7156412
Autor:
Sara J. Buhrlage, Xiaoxi Liu, Jing Yang, Jinhua Wang, Abigail E Case, Sophia Adamia, Richard Stone, Chengcheng Meng, Prafulla C. Gokhale, Nathanael S. Gray, Ellen Weisberg, James D. Griffin, Hong L. Tiv, Martin Sattler
Publikováno v:
Journal of Cellular and Molecular Medicine
Recently, several targeted agents have been developed for specific subsets of patients with acute myeloid leukaemia (AML), including midostaurin, the first FDA‐approved FLT3 inhibitor for newly diagnosed patients with FLT3 mutations. However, in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9b94066f50c52e1dc6c57cf1a73e7e
https://doi.org/10.1111/jcmm.14927
https://doi.org/10.1111/jcmm.14927