Výsledky vyhledávání - "Cheng-kun Xia"

Akademický článek

Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias

Autor: Chen-Chen Hu, Xin Wei, Jin-Min Liu, Lin-Lin Han, Cheng-Kun Xia, Jing Wu, Tao You, A.-Fang Zhu, Shang-Long Yao, Shi-Ying Yuan, Hao-Dong Xu, Zheng-Yuan Xia, Ting-Ting Wang, Wei-Ke Mao

Publikováno v: Military Medical Research, Vol 9, Iss 1, Pp 1-17 (2022)

Abstract Background Abnormal myocardial Nav1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO modification af

Externí odkaz: https://doaj.org/article/624c06021b9c4002aa0a60513aa31530

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Akademický článek

Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1)

Autor: Qian Dong, Ning Zhao, Cheng-kun Xia, Li-li Du, Xiao-xing Fu, Yi-mei Du

Publikováno v: Biomolecules & Biomedicine, Vol 12, Iss 3 (2012)

Hypoxia-inducible factor-1 (HIF-1) regulates the expression of hypoxia-inducible genes by binding erythropoietin (EPO) enhancer fragments. Of these genes, HIF-1 upregulates voltage-gated K+1.2 channels (Kv1.2) in rat PC12 cells. Whether HIF-1 regulat

Externí odkaz: https://doaj.org/article/3d6582ff147e4810b17e894dd5763396

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Akademický článek

H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer

Autor: Cheng-Kun Xiao, Yuexiang Ren, Qianxin Chen, Yuanzhong Yang, Luying Tang, Lin Xu, Zefang Ren

Publikováno v: Epigenetics, Vol 19, Iss 1 (2024)

Previous studies have indicated that histone methylations act as mediators in the relationship between oestrogen receptor (ER) and breast cancer prognosis, yet the mediating role has never been assessed. Therefore, we investigated seven histone methy

Externí odkaz: https://doaj.org/article/605f46daa4f1474a9baa7030da935d08

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Cardiac-targeted PIASy Gene Silencing Mediates deSUMOylation of Caveolin-3 and Prevents Ischemia/reperfusion-induced Nav1.5 Down-regulation and Ventricular Arrhythmias

Autor: Chen-Chen Hu, Xin Wei, Jin-Min Liu, Lin-Lin Han, Cheng-Kun Xia, Jing Wu, Tao You, A.-Fang Zhu, Shang-Long Yao, Shi-Ying Yuan, Hao-Dong Xu, Zheng-Yuan Xia, Ting-Ting Wang, Wei-Ke Mao

Background Abnormal myocardial Nav1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO modification affects Cav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7a9079c9edfa3b9b6a32d0e7d91802
https://doi.org/10.21203/rs.3.rs-1163593/v1

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Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Na

Autor: Chen-Chen, Hu, Xin, Wei, Jin-Min, Liu, Lin-Lin, Han, Cheng-Kun, Xia, Jing, Wu, Tao, You, A-Fang, Zhu, Shang-Long, Yao, Shi-Ying, Yuan, Hao-Dong, Xu, Zheng-Yuan, Xia, Ting-Ting, Wang, Wei-Ke, Mao

Publikováno v: Military Medical Research. 9(1)

Abnormal myocardial NaUsing recombinant adeno-associated virus subtype 9 (AAV9), rat cardiac PIASy was silenced using intraventricular injection of PIASy short hairpin RNA (shRNA). After two weeks, rat hearts were subjected to I/R and electrocardiogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df7f30bf6b6e2e40d355f69f1120c530
https://pubmed.ncbi.nlm.nih.gov/36229865

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Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1)

Autor: Cheng-kun Xia, Li-Li Du, Qian Dong, Ning Zhao, Xiao-Xing Fu, Yimei Du

Publikováno v: Bosnian Journal of Basic Medical Sciences, Vol 12, Iss 3 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8806fcb85e03d9d55f476b0e6a7b8c
http://www.bjbms.org/ojs/index.php/bjbms/article/view/2463

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18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels

Autor: Ming Lei, Ning Zhao, Cheng-kun Xia, Yimei Du, Qian Dong, Jia-hong Xia

To compare the effects of two stereoisomeric forms of glycyrrhetinic acid on different components of Na(+) current, HERG and Kv1.5 channel currents.Wild-type (WT) and long QT syndrome type 3 (LQT-3) mutant ΔKPQ Nav1.5 channels, as well as HERG and K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ae6c8a92ea038c0ab58b9bc3913cfd
https://europepmc.org/articles/PMC4010371/

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Effects of acetylcholine on electrical remodeling of human atrial fibers

Autor: Yimei Du, Zhigang Shui, Jiahong Xia, Jinping Liu, Wei Sun, Guoliang Hao, Cheng-kun Xia

Publikováno v: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 31(2)

Autonomic nervous system activation can result in significant changes of atrial electrophysiology and facilitate induction of atrial fibrillation. By recording influence of different concentrations of acetylcholine (ACh) on atrial fibers (AF), we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6181d5d951290361a840340a04551eb4
https://pubmed.ncbi.nlm.nih.gov/21505977

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