Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cheng-Tai Lu"'
Autor:
Cheng-Tai Lu, 呂承泰
102
Since the Nationalist government moved to Taiwan in 1949, the two sides have launched a long confrontation with the political divide and conquer. As a result, the Straits of governance has continued until today. The name has been arguing wit
Since the Nationalist government moved to Taiwan in 1949, the two sides have launched a long confrontation with the political divide and conquer. As a result, the Straits of governance has continued until today. The name has been arguing wit
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/9ptkqj
Autor:
Su-Ying Wu, Tsu Hsu, Weir-Torn Jiaang, Ching-Cheng Hsueh, Hsin-Huei Chang, Fang-Chun Kung, Cheng-Tai Lu, Yi-Hui Peng, Ching-Chuan Kuo, Lung-Chun Lee, Chih-Hsiang Huang
Publikováno v:
Journal of Medicinal Chemistry
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays an important role in one-carbon metabolism. The MTHFD2 gene is upregulated in various cancers but very low or undetectable in normal proliferating cells, and therefore a potential target for ca
Autor:
Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo
Publikováno v:
Journal of Medicinal Chemistry. 62:11135-11150
Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these
Autor:
Tsu Hsu, Yi-Hui Peng, Yu-Chieh Su, Weir-Torn Jiaang, Jia-Yu Chang, Hui-You Lin, Teng-Kuang Yeh, Cheng-Tai Lu, Tsung-Sheng Wu, Hui Yi Shiao, Chiung-Tong Chen, Jen-Shin Song, Wen-Hsing Lin, Pei-Chen Wang, Su-Ying Wu, Li-Tzong Chen, Ching-Cheng Hsueh, Fang-Chun Kung, Hui-Jen Tsai, Lung-Chun Lee, Chih-Hsiang Tu
Publikováno v:
Journal of Medicinal Chemistry. 62:3940-3957
Drug resistance due to acquired mutations that constitutively activate c-KIT is a significant challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). Herein, we identified 1-(5-ethyl-isoxazol-3-yl)-3-(4-{2-[6-(4-ethylpipe
Autor:
Ming-Yen Hsieh, Weir-Torn Jiaang, Chiung-Tong Chen, Cheng-Tai Lu, Fang-Chun Kung, Teng-Kuang Yeh, Zheng-Sheng Lai, Tsu Hsu, Chun-Hung Lin, Che Kun James Shen, Yu Chi Chou
Publikováno v:
European Journal of Medicinal Chemistry. 209:112938
Reactivation of fetal hemoglobin (HbF) expression by therapeutic agents has been suggested as an alternative treatment to modulate anemia and the related symptoms of severe β-thalassemia and sickle cell disease (SCD). Hydroxyurea (HU) is the first U
Autor:
Kuei Jung Yen, Tsu Hsu, Ling Hui Chou, Yu Ling Huang, Yu-Sheng Chao, H. Eugene Liu, Cheng Tai Lu, Teng Kuang Yeh, Weir-Torn Jiaang, Jen Shin Song, Chun Hwa Chen, Po Chu Kuo, Ching Ping Chen, Shih Chieh Yen, Chiung-Tong Chen, Wen-Hsing Lin, Chen Lung Huang, John T.A. Hsu
Publikováno v:
European Journal of Medicinal Chemistry. 100:151-161
Numerous FLT3 inhibitors have been explored as a viable therapy for the treatment of acute myeloid leukemia (AML). However, clinical data have been underwhelming due to incomplete inhibition of FLT3 or the emergence of resistant mutations treated wit
Autor:
Weir-Torn Jiaang, John T.A. Hsu, Yi-Yu Ke, Chun Wei Chang, Mohane Selvaraj Coumar, Ya-Hui Chi, Hsing Pang Hsieh, Chang-Ying Chu, Po-Chu Kuo, Chiung-Tong Chen, Chun-Hwa Chen, Hui Yi Shiao, Wen-Hsing Lin, Chin-Ting Huang, Kai-Yen Chang, Hsu-Yi Sun, Yu-Sheng Chao, Ka-Shu Fung, Cheng-Tai Lu
Publikováno v:
Journal of Medicinal Chemistry. 56:5247-5260
Ligand efficiency (LE) and lipophilic efficiency (LipE) are two important indicators of "drug-likeness", which are dependent on the molecule's activity and physicochemical properties. We recently reported a furano-pyrimidine Aurora kinase inhibitor 4
Autor:
Yung-Ning Yang, Wen-Hsing Lin, Ching-Ping Chen, Tsu Hsu, John T.A. Hsu, Weir-Torn Jiaang, Yu-Sheng Chao, Ching-Fang Yeh, Ling-Hui Chou, Chun-Hwa Chen, Teng-Kuang Yeh, Jen-Shin Song, Chiung-Tong Chen, Shu-Yi Hsieh, Cheng-Tai Lu, Ching-Hui Chiu, Shih-Chieh Yen, Ya-Ju Tseng, Kuei-Jung Yen
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2856-2867
Preclinical investigations and early clinical trials suggest that FLT3 inhibitors are a viable therapy for acute myeloid leukemia. However, early clinical data have been underwhelming due to incomplete inhibition of FLT3. We have developed 3-phenyl-1
Autor:
Weir-Torn Jiaang, Ping-Chiang Lyu, Wen-Hsing Lin, Chuan Shih, Su-Ying Wu, Jian-Sung Wu, Chih-Hsiang Tu, Chun-Yu Chang, Cheng-Tai Lu, Yi-Hui Peng, Tsu Hsu
Publikováno v:
Journal of medicinal chemistry. 59(8)
Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)
Autor:
John T.A. Hsu, Teng-Kuang Yeh, Cheng-Tai Lu, Chun-Wha Chen, An-Huei Cheng, Chiung-Tong Chen, Yun-I Chang, Yu-Lin Huang, Ya-Ju Tseng, Kuei-Rong Yen, Shu-Yi Hsieh, Ling-Hui Chou, Yu-Sheng Chao, Tsu Hsu, Ching-Ping Chen, Shih-Chieh Yen, Wen-Hsing Lin, Weir-Torn Jiaang
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4173-4182
Preclinical investigations and early clinical trial studies suggest that FLT3 inhibitors offer a viable therapy for acute myeloid leukemia. However, early clinical data for direct FLT3 inhibitors provided only modest results because of the failure to