Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Cheng-Kun Du"'
Publikováno v:
Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)
Abstract Serotonin (5‐HT) accumulates in the heart during myocardial ischemia and induces deleterious effects on the cardiomyocytes through receptor‐dependent and monoamine oxidase‐dependent pathways. We aimed to clarify the involvement of extr
Externí odkaz:
https://doaj.org/article/b67ebee1854d4b2b8d50bdff0588a9ed
Autor:
James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, Daryl O Schwenke
Publikováno v:
Vascular Biology, Vol 1, Iss 1, Pp H97-H102 (2019)
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function
Externí odkaz:
https://doaj.org/article/5a0dbb4f12df4203bf8e2a9d84c7af1a
Autor:
Rajesh Katare, James T. Pearson, Jason Kar-Sheng Lew, Melanie Wei, Hirotsugu Tsuchimouchi, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Mikiyasu Shirai, Daryl O. Schwenke
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD) remain to be fully elucidated. Myocardial function is critically dependent on optimal coronary blood flow. Considering vascular disease occurs early
Externí odkaz:
https://doaj.org/article/074be22372744553be93780c7e6c2f11
Autor:
Hirotsugu Tsuchimochi, Takashi Sonobe, Keiji Umetani, Amanda J. Edgley, Mikiyasu Shirai, Dong Yun Zhan, Tadakatsu Inagaki, Jennifer P. Ngo, Yutaka Fujii, Hamish P Thambyah, James T. Pearson, Yi Ching Chen, Mark T. Waddingham, Cheng-Kun Du, Connie P. C. Ow, Darren J. Kelly, Vijayakumar Sukumaran
Publikováno v:
Clinical Science. 135:327-346
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a8c1dd511f90ba30d7f2447eb245e1
https://doi.org/10.1042/cs20201441
https://doi.org/10.1042/cs20201441
Autor:
Hiroyuki Kawagishi, Mitsuhiko Yamada, Cheng-Kun Du, Tsutomu Nakada, Toshihide Kashihara, Sachio Morimoto, Elena E. Wolf, Shin Kadota, Takuro Numaga-Tomita, Yuji Shiba
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • β-arrestin–biased AT1 agonist TRV027 causes a neonatal-specific, long-acting positive inotropic effect with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone s
Highlights • β-arrestin–biased AT1 agonist TRV027 causes a neonatal-specific, long-acting positive inotropic effect with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f2d81ed3d68f51843a352e270a974b
https://soar-ir.repo.nii.ac.jp/records/2001244
https://soar-ir.repo.nii.ac.jp/records/2001244
Autor:
Melanie Wei, Meihua Jin, Jason Kar Sheng Lew, Eugene Saw, Mikiyasu Shirai, Dong Yun Zhan, Cheng-Kun Du, Keiji Umetani, James T. Pearson, Rajesh Katare, Daryl O. Schwenke, Nilanjan Ghosh, Hirotsugu Tsuchimochi
Publikováno v:
Circ Res
Rationale: Diabetic heart disease (DHD) is a debilitating manifestation of type 2 diabetes mellitus. Exercise has been proposed as a potential therapy for DHD, although the effectiveness of exercise in preventing or reversing the progression of DHD r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21917217592d1aec1176fcf5f289937d
https://doi.org/10.1161/circresaha.120.317604
https://doi.org/10.1161/circresaha.120.317604
Autor:
Hirotsugu Tsuchimochi, Vijayakumar Sukumaran, Hiroshi Hosoda, Jennifer P. Ngo, James T. Pearson, Akihiro Fujiwara, Roger G. Evans, Cheng-Kun Du, Connie P. C. Ow
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Chronic kidney disease (CKD) is an ever-growing concern and CKD associated with diabetes accounted for ∼ 35% of new cases of end-stage renal failure. Clinical trials with insulin-independent sodium-glucose co-transporter 2 (SGLT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6f64af59ff67d8c49444229528c792
https://doi.org/10.1093/ndt/gfaa142.p0978
https://doi.org/10.1093/ndt/gfaa142.p0978
Autor:
Mikiyasu Shirai, Hirotsugu Tsuchimochi, Daryl O. Schwenke, Vijayakumar Sukumaran, Rajesh Katare, Takashi Sonobe, James T. Pearson, Cheng-Kun Du, Mark T. Waddingham
Publikováno v:
Vascular Biology, Vol 1, Iss 1, Pp H97-H102 (2019)
Vascular Biology
Vascular Biology
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bffee5e62cd435838d3b336af0deff
https://vb.bioscientifica.com/view/journals/vb/1/1/VB-19-0024.xml
https://vb.bioscientifica.com/view/journals/vb/1/1/VB-19-0024.xml
Autor:
Masaki Arioka, Tatsuya Yoshihara, Rasha M. S. M. Mohamed, Toshiyuki Sasaguri, Cheng-Kun Du, Dong Yun Zhan, Sachio Morimoto, Islam A.A.E.-H. Ibrahim, Fumi Takahashi-Yanaga
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H1808-H1815
Glycogen synthase kinase-3β (GSK-3β) plays a central role in both cardiac physiology and pathology. Herein we want to clarify the role of GSK-3β in familial dilated cardiomyopathy. We generated a mouse model carrying a heterozygous knockout mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0df1132ecc06e401c3f29d0e36659f
https://doi.org/10.1152/ajpheart.00771.2015
https://doi.org/10.1152/ajpheart.00771.2015
Autor:
Ryo Tanaka, Takuro Arimura, Taisuke Ishikawa, Akinori Kimura, Shu Nakao, Cheng-Kun Du, Dong Yun Zhan, Takeharu Hayashi, Masayoshi Kuwahara, Antoine Muchir, Sachio Morimoto, Yoshihisa Yamane, Noboru Machida
Publikováno v:
AJP-Heart and Circulatory Physiology
AJP-Heart and Circulatory Physiology, 2018, 314 (6), pp.H1192-H1202. ⟨10.1152/ajpheart.00696.2017⟩
AJP-Heart and Circulatory Physiology, 2018, 314 (6), pp.H1192-H1202. ⟨10.1152/ajpheart.00696.2017⟩
Mutations in genes encoding components of the sarcomere cause cardiomyopathy, which is often associated with abnormal Ca2+sensitivity of muscle contraction. We have previously shown that a heart-specific myosin light chain phosphatase small subunit (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e762464fdc55821fe6553f4719d6a9ed
https://hal.science/hal-03859515
https://hal.science/hal-03859515
