Výsledky vyhledávání - "Cheng-Kun Du"

Akademický článek

Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia‐reperfusion in the rat heart in vivo

Autor: Takashi Sonobe, Tsuyoshi Akiyama, Cheng‐Kun Du, James T. Pearson

Publikováno v: Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)

Abstract Serotonin (5‐HT) accumulates in the heart during myocardial ischemia and induces deleterious effects on the cardiomyocytes through receptor‐dependent and monoamine oxidase‐dependent pathways. We aimed to clarify the involvement of extr

Externí odkaz: https://doaj.org/article/b67ebee1854d4b2b8d50bdff0588a9ed

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Akademický článek

Ghrelin and vascular protection

Autor: James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, Daryl O Schwenke

Publikováno v: Vascular Biology, Vol 1, Iss 1, Pp H97-H102 (2019)

Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function

Externí odkaz: https://doaj.org/article/5a0dbb4f12df4203bf8e2a9d84c7af1a

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Akademický článek

Progressive Decrease in Coronary Vascular Function Associated With Type 2 Diabetic Heart Disease

Autor: Rajesh Katare, James T. Pearson, Jason Kar-Sheng Lew, Melanie Wei, Hirotsugu Tsuchimouchi, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Mikiyasu Shirai, Daryl O. Schwenke

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD) remain to be fully elucidated. Myocardial function is critically dependent on optimal coronary blood flow. Considering vascular disease occurs early

Externí odkaz: https://doaj.org/article/074be22372744553be93780c7e6c2f11

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β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat

Autor: Hirotsugu Tsuchimochi, Takashi Sonobe, Keiji Umetani, Amanda J. Edgley, Mikiyasu Shirai, Dong Yun Zhan, Tadakatsu Inagaki, Jennifer P. Ngo, Yutaka Fujii, Hamish P Thambyah, James T. Pearson, Yi Ching Chen, Mark T. Waddingham, Cheng-Kun Du, Connie P. C. Ow, Darren J. Kelly, Vijayakumar Sukumaran

Publikováno v: Clinical Science. 135:327-346

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor block

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a8c1dd511f90ba30d7f2447eb245e1
https://doi.org/10.1042/cs20201441

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β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate

Autor: Hiroyuki Kawagishi, Mitsuhiko Yamada, Cheng-Kun Du, Tsutomu Nakada, Toshihide Kashihara, Sachio Morimoto, Elena E. Wolf, Shin Kadota, Takuro Numaga-Tomita, Yuji Shiba

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • β-arrestin–biased AT1 agonist TRV027 causes a neonatal-specific, long-acting positive inotropic effect with minimum effect on heart rate, oxygen consumption, reactive oxygen species production, and aldosterone s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f2d81ed3d68f51843a352e270a974b
https://soar-ir.repo.nii.ac.jp/records/2001244

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Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart

Autor: Melanie Wei, Meihua Jin, Jason Kar Sheng Lew, Eugene Saw, Mikiyasu Shirai, Dong Yun Zhan, Cheng-Kun Du, Keiji Umetani, James T. Pearson, Rajesh Katare, Daryl O. Schwenke, Nilanjan Ghosh, Hirotsugu Tsuchimochi

Publikováno v: Circ Res

Rationale: Diabetic heart disease (DHD) is a debilitating manifestation of type 2 diabetes mellitus. Exercise has been proposed as a potential therapy for DHD, although the effectiveness of exercise in preventing or reversing the progression of DHD r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21917217592d1aec1176fcf5f289937d
https://doi.org/10.1161/circresaha.120.317604

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P0978THE EFFECTS OF CHRONIC DAPAGLIFLOZIN TREATMENT ON THE RENAL MICROVASCULATURE IN A RAT MODEL OF TYPE 2 DIABETES

Autor: Hirotsugu Tsuchimochi, Vijayakumar Sukumaran, Hiroshi Hosoda, Jennifer P. Ngo, James T. Pearson, Akihiro Fujiwara, Roger G. Evans, Cheng-Kun Du, Connie P. C. Ow

Publikováno v: Nephrology Dialysis Transplantation. 35

Background and Aims Chronic kidney disease (CKD) is an ever-growing concern and CKD associated with diabetes accounted for ∼ 35% of new cases of end-stage renal failure. Clinical trials with insulin-independent sodium-glucose co-transporter 2 (SGLT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc6f64af59ff67d8c49444229528c792
https://doi.org/10.1093/ndt/gfaa142.p0978

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