Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cheng-I. Mau"'
Autor:
Cheng-I. Mau, Andreas Jekle, Ferenc Makra, Surya Sankuratri, Paul Weller, André deRosier, Eun Kyung Lee, Gabriel Stephen Deems, Gabrielle Heilek, David Mark Rotstein, Changhua Ji, Shelley K. Gleason, Christine E. Brotherton-Pleiss, Marianna Dioszegi, Lubov Filonova, Lina Setti, Pamela Berry, Alejandra Trejo-Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5401-5406
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12820458536333a16236817f9aa665
https://doi.org/10.1016/j.bmcl.2009.07.122
https://doi.org/10.1016/j.bmcl.2009.07.122
Autor:
André deRosier, David G. Loughhead, David Mark Rotstein, Shelley K. Gleason, Eun Kyung Lee, Fernando Padilla, Lina Setti, Dick Cournoyer, Remy Lemoine, Cheng-I. Mau, Paul Weller, Andreas Jekle, Jutta Wanner, Pamela Berry, Chris Richard Melville, Marianna Dioszegi, Ann C. Petersen, Surya Sankuratri, Jason Manka, Changhua Ji, Lin Xiao-Fa, Lijing Chen, Gabrielle Heilek, Lubov Filonova
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757bbb465169e0977e2a95f17e17d1e6
https://pubmed.ncbi.nlm.nih.gov/20417098
https://pubmed.ncbi.nlm.nih.gov/20417098
Autor:
Michael F. Powell, Robert Bergstrom, Kyle Hama, Foster Linda Cheryl, Adina Magill, Cheng I. Mau, Nancy Chu
Publikováno v:
Pharmaceutical Research. :1418-1423
We report the chemical and enzymatic hydrolysis of two hydrophobic prodrugs of ganciclovir (3 = dipropionate ester; 4 = diadamantoate ester). Both prodrugs undergo hydrolysis showing a pH dependence of kobs = kH+ aH+ + ko + kHO-aHO− and a pH of max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24f1ddc5c39d7195f5cb4be45a6f57b
https://doi.org/10.1023/a:1015809408908
https://doi.org/10.1023/a:1015809408908
Autor:
Tom Alfredson, Than Hendricks, Cheng-I Mau, Calvin Yee, Chuck Dvorak, Lei Hong, Harris Jason R, Fujun Li, Rebecca Chan
Publikováno v:
Journal of pharmaceutical sciences. 95(6)
The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd51b66a4382cd3688a71d7d3f2b12f
https://pubmed.ncbi.nlm.nih.gov/16634069
https://pubmed.ncbi.nlm.nih.gov/16634069
Autor:
Paul Kopeck, Mercidita T. Navarro, Ritu Lal, Tom Alfredson, Susanne Ostrowitzki, George Hill, Nancy Berger, Yue Huang, Cheng I. Mau
Publikováno v:
Journal of clinical pharmacology. 45(5)
R1518 is a valine ester prodrug of levovirin as an investigational new drug for the treatment of hepatitis C virus. Two phase 1, single- and multiple-dose studies were conducted to investigate the pharmacokinetics of R1518 in healthy volunteers. Afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc03cee391f5c9dcafb7cdf5c37b64f
https://pubmed.ncbi.nlm.nih.gov/15831782
https://pubmed.ncbi.nlm.nih.gov/15831782
Autor:
Fujun Li1 fujun.li@roche.com, Lei Hong1, Cheng-I Mau2, Chan, Rebecca2, Hendricks, Than3, Dvorak, Chuck4, Yee, Calvin3, Harris, Jason3, Alfredson, Tom1
Publikováno v:
Journal of Pharmaceutical Sciences. Jun2006, Vol. 95 Issue 6, p1318-1325. 8p. 1 Diagram, 5 Charts, 3 Graphs.