Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Cheng-Hsin Lee"'
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Cancer cells promote glycolysis, which supports rapid cell growth and proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs), a family of bidirectional glycolytic enzymes, play key roles in the regulation of glycolys
Externí odkaz:
https://doaj.org/article/1a442da11907431dbe220ff0382cdebd
Autor:
Yung-Fu Chang, Hsing-Hsang Wang, Chih-Wen Shu, Wei-Lun Tsai, Cheng-Hsin Lee, Chun-Lin Chen, Pei-Feng Liu
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4529-4543 (2023)
Colon cancer is the third most important cancer type, leading to a remarkable number of deaths, indicating the necessity of new biomarkers and therapeutic targets for colon cancer patients. Several transmembrane proteins (TMEMs) are associated with t
Externí odkaz:
https://doaj.org/article/3c4cdb5cff65483fb18c3a886adfd7fc
Autor:
Chung-Chih Tseng, Chung-Ching Hung, Chih-Wen Shu, Cheng-Hsin Lee, Chun-Feng Chen, Mei-Shu Kuo, Yu-Ying Kao, Chun-Lin Chen, Luo-Ping Ger, Pei-Feng Liu
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1270 (2023)
There are currently no effective biomarkers for the diagnosis and treatment of tongue squamous cell carcinoma (TSCC), which causes a poor 5-year overall survival rate. Thus, it is crucial to identify more effective diagnostic/prognostic biomarkers an
Externí odkaz:
https://doaj.org/article/7c1eb0458f744cb5b854816f8d2fe806
Autor:
Samir Mehndiratta, Mei-Chuan Chen, Yuh-Hsuan Chao, Cheng-Hsin Lee, Jing-Ping Liou, Mei-Jung Lai, Hsueh-Yun Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 74-84 (2021)
A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that subs
Externí odkaz:
https://doaj.org/article/c7b114e2cce340f3bb76c939739aacb5
Autor:
Pei‐Feng Liu, Chun‐Feng Chen, Luo‐Ping Ger, Wei‐Lun Tsai, Ho‐Hsing Tseng, Cheng‐Hsin Lee, Wen‐Hsin Yang, Chih‐Wen Shu
Publikováno v:
Journal of Cellular Physiology. 237:4275-4291
Autophagy-related 4B (ATG4B) is a protease required for core machinery of autophagy. Phosphorylation of ATG4B promotes autophagy and is correlated with poor outcome of cancer. However, little is known about the upstream kinases for ATG4B phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0741069dc0b5ade96c65c220f933238b
https://doi.org/10.1002/jcp.30881
https://doi.org/10.1002/jcp.30881
Autor:
Yu-Kai Tseng, Chun-Feng Chen, Chih-Wen Shu, Cheng-Hsin Lee, Yan-Ting Chou, Yi-Jing Li, Huei-Han Liou, Jiin-Tsuey Cheng, Chun-Lin Chen, Luo-Ping Ger, Pei-Feng Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12226 (2021)
Oral squamous cell carcinoma (OSCC) is one of the most common types of malignant tumor. Sequestosome 1 (SQSTM1) serves as an adaptor of autophagy for degrading protein aggregates. The regulation of autophagy by EGFR and its clinical impacts are indic
Externí odkaz:
https://doaj.org/article/5ca87154c7174028ac89c392c7f9be16
Autor:
Pei-Feng Liu, Chih-Wen Shu, Hsiu-Chen Yang, Cheng-Hsin Lee, Huei-Han Liou, Luo-Ping Ger, Yen-Dun Tony Tzeng, Wen-Ching Wang
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1514 (2021)
Breast cancer is the leading cause of cancer death in women worldwide. The microtubule-associated protein light chain 3B (MAP1LC3B) and adaptor sequestosome 1 (SQSTM1) are two major markers for autophagy. Increased protein levels of MAP1LC3B and SQST
Externí odkaz:
https://doaj.org/article/c14a1d12b6d4425d880982a056e78aa1
Autor:
Tzu-Jung Yu, Sheng-Chieh Wang, Pei-Feng Liu, Hans-Uwe Dahms, Jen-Yang Tang, Hsueh-Wei Chang, Cheng-Hsin Lee, Ammad Ahmad Farooqi, Sheng-Yao Peng, Chih-Wen Shu
Publikováno v:
Seminars in Cancer Biology. 83:269-282
Noncoding RNAs (ncRNAs) regulation of various diseases including cancer has been extensively studied. Reactive oxidative species (ROS) elevated by oxidative stress are associated with cancer progression and drug resistance, while autophagy serves as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322e2276e992d1a2f97f18cc59ab89f8
https://doi.org/10.1016/j.semcancer.2020.10.009
https://doi.org/10.1016/j.semcancer.2020.10.009
Autor:
Jin-Shiung Cheng, Wei-Lun Tsai, Pei-Feng Liu, Yih-Gang Goan, Chih-Wen Lin, Ho-Hsing Tseng, Cheng-Hsin Lee, Chih-Wen Shu
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Targeted therapy is currently limited for patients with hepatocellular carcinoma (HCC) due to the lack of suitable targets. Kinases play pivotal roles in many cellular biological processes, whereas dysregulation of kinases may lead to various disease
Externí odkaz:
https://doaj.org/article/2695976bf92348f5a784fa62c83bc150
Autor:
Wan-Hsiang Hu, Wen-Chi Yang, Pei-Feng Liu, Ting-Ting Liu, Paul Morgan, Wei-Lun Tsai, Hung-Wei Pan, Cheng-Hsin Lee, Chih-Wen Shu
Publikováno v:
Diagnostics, Vol 11, Iss 5, p 782 (2021)
Gene mutation and pathogenesis bacteria are highly associated with colorectal cancer (CRC) development and progression. Autophagy is a self-clearance pathway to degrade abnormal proteins and infected bacteria in cells. Autophagy plays a dual role in
Externí odkaz:
https://doaj.org/article/51f8d1c327ab4623943ab78e1d91aa96