Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Cheng-Guo Wu"'
Autor:
Yitong Li, Vijaya Kumar Balakrishnan, Michael Rowse, Cheng-Guo Wu, Anastasia Phoebe Bravos, Vikash K Yadav, Ylva Ivarsson, Stefan Strack, Irina V Novikova, Yongna Xing
Publikováno v:
eLife, Vol 11 (2022)
Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core en
Externí odkaz:
https://doaj.org/article/c37f531dac834f918655f6dade4f99cc
Autor:
Cheng-Guo Wu, Aiping Zheng, Li Jiang, Michael Rowse, Vitali Stanevich, Hui Chen, Yitong Li, Kenneth A. Satyshur, Benjamin Johnson, Ting-Jia Gu, Zuojia Liu, Yongna Xing
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Protein phosphatase 2A (PP2A) forms different holoenzymes but little is known about the disassembly of these important signalling complexes. Here the authors present the crystal structure of PP2A bound to TOR signaling pathway regulator (TIPRL) and g
Externí odkaz:
https://doaj.org/article/94a35d46f87a45ba809c7ceade92ca57
Autor:
Cheng-Guo Wu, Balakrishnan, Vijaya K., Merrill, Ronald A., Parihar, Pankaj S., Konovolov, Kirill, Yu-Chia Chen, Zhen Xu, Hui Wei, Sundaresan, Ramya, Qiang Cui, Wadzinski, Brian E., Swingle, Mark R., Musiyenko, Alla, Chung, Wendy K., Honkanen, Richard E., Suzuki, Aussie, Xuhui Huang, Strack, Stefan, Yongna Xing
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/2/2024, Vol. 121 Issue 1, p1-12, 41p
Autor:
Cheng-Guo Wu, Vijaya K. Balakrishnan, Pankaj S. Parihar, Kirill Konovolov, Yu-Chia Chen, Ronald A Merrill, Hui Wei, Bridget Carragher, Ramya Sundaresan, Qiang Cui, Brian E. Wadzinski, Mark R. Swingle, Alla Musiyenko, Richard Honkanen, Wendy K. Chung, Aussie Suzuki, Stefan Strack, Xuhui Huang, Yongna Xing
An increasing number of mutations associated with devastating human diseases are diagnosed by whole-genome/exon sequencing. Recurrentde novomissense mutations have been discovered in B56δ (encoded byPPP2R5D), a regulatory subunit of protein phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c7723ac5bfc49c8706fa023d5ad09e
https://doi.org/10.1101/2023.03.09.530109
https://doi.org/10.1101/2023.03.09.530109
Autor:
Joseph R. Bertino, Yong Wei, Minhong Shen, Yibin Kang, Stacy Remiszewski, Liling Wan, Michael Raba, John F. Jin, Cheng-Guo Wu, Min Yuan, Michelle Rowicki, Zhi-Ming Shao, Aiping Zheng, Yongna Xing, Hahn Kim, Song-Yang Wu, Heath A. Smith, Xin Lu, Xiang Hang, Yi-Zhou Jiang, Lanjing Zhang
Publikováno v:
Nature Cancer. 3:43-59
Metastatic breast cancer is a leading health burden worldwide. Previous studies have shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy resistance; however, the therapeutic potential of targeting MTDH remains large
Autor:
Yitong Li, Vijaya Kumar Balakrishnan, Michael Rowse, Cheng-Guo Wu, Anastasia Phoebe Bravos, Vikash K Yadav, Ylva Ivarsson, Stefan Strack, Irina V Novikova, Yongna Xing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dab23463bdc9fbad675082f46fe6ce3
https://doi.org/10.7554/elife.79736.sa2
https://doi.org/10.7554/elife.79736.sa2
Autor:
Weili Miao, Douglas F. Porter, Vanessa Lopez-Pajares, Zurab Siprashvili, Robin M. Meyers, Yunhao Bai, Duy T. Nguyen, Lisa A. Ko, Brian J. Zarnegar, Ian D. Ferguson, Matthew M. Mills, Christie E. Jilly-Rehak, Cheng-Guo Wu, Yen-Yu Yang, Jordan M. Meyers, Audrey W. Hong, David L. Reynolds, Muthukumar Ramanathan, Shiying Tao, Sizun Jiang, Ryan A. Flynn, Yinsheng Wang, Garry P. Nolan, Paul A. Khavari
Publikováno v:
Cell. 186(1)
Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose bi
Autor:
Anastasia Bravos, Yongna Xing, Stefan Strack, YIva Ivarsson, Cheng-Guo Wu, Yitong Li, Michael Rowse
Protein phosphatase 2A (PP2A) methylesterase 1 (PME-1) is cancer-promoting but essential for development, and long-believed to remove carboxymethylation, a central modification, from the common PP2A core enzyme but not diverse holoenzymes that target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::435cb9697a69f1846c93c7cd5aa16952
https://doi.org/10.21203/rs.3.rs-372534/v1
https://doi.org/10.21203/rs.3.rs-372534/v1
Autor:
Minhong, Shen, Yong, Wei, Hahn, Kim, Liling, Wan, Yi-Zhou, Jiang, Xiang, Hang, Michael, Raba, Stacy, Remiszewski, Michelle, Rowicki, Cheng-Guo, Wu, Songyang, Wu, Lanjing, Zhang, Xin, Lu, Min, Yuan, Heath A, Smith, Aiping, Zheng, Joseph, Bertino, John F, Jin, Yongna, Xing, Zhi-Ming, Shao, Yibin, Kang
Publikováno v:
Nature cancer. 3(1)
Metastatic breast cancer is a leading health burden worldwide. Previous studies have shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy resistance; however, the therapeutic potential of targeting MTDH remains large
Autor:
Hui Chen, Yongna Xing, Li Jiang, Yitong Li, Ting-Jia Gu, Aiping Zheng, Kenneth A. Satyshur, Zuojia Liu, Michael Rowse, Cheng-Guo Wu, Vitali Stanevich, Benjamin Johnson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions. Specialized latency and activation chaperones control the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a common scaffold and catalytic sub