Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Cheng-Dong Li"'
1
Akademický článek
Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations
Autor: Cheng-Dong Li, Muhammad Junaid, Xiaoqi Shan, Yanjing Wang, Xiangeng Wang, Abbas Khan, Dong-Qing Wei
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
C99 is the immediate precursor for amyloid beta (Aβ) and therefore is a central intermediate in the pathway that is believed to result in Alzheimer’s disease (AD). It has been suggested that cholesterol is associated with C99, but the dynamic deta
Externí odkaz: https://doaj.org/article/1d3b7c391c144e86b4df9b71d3253ec6
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2
Akademický článek
Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
Autor: Abbas Khan, Ashfaq-Ur-Rehman, Muhammad Junaid, Cheng-Dong Li, Shoaib Saleem, Fahad Humayun, Shazia Shamas, Syed Shujait Ali, Zainib Babar, Dong-Qing Wei
Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2020)
Incidents of breast cancer (BC) are on the rise on a daily basis and have proven to be the most prevelant cause of death for women in both developed and developing countries. Among total BC cases diagnosed after menopause, 70% of cases are Estrogen R
Externí odkaz: https://doaj.org/article/d81fdb2468c744a68468afbb925bbd88
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3
Akademický článek
Effects of ZnS modification on primary Si in hypereutectic Al-Si alloy
Autor: Cheng-dong Li, Chuan-hao Sun, Wen-qiang Si
Publikováno v: China Foundry, Vol 14, Iss 2, Pp 93-97 (2017)
A new modifying agent, ZnS, was used as a refiner to modify primary silicon in hypereutectic Al-Si alloy. The factors affecting the modification results, including addition level of ZnS and holding time, were investigated. The results showed that the
Externí odkaz: https://doaj.org/article/67f0dae0a0954b3a93ed6145e1f3ad36
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4
Akademický článek
STS-NLSP: A Network-Based Label Space Partition Method for Predicting the Specificity of Membrane Transporter Substrates Using a Hybrid Feature of Structural and Semantic Similarity
Autor: Xiangeng Wang, Xiaolei Zhu, Mingzhi Ye, Yanjing Wang, Cheng-Dong Li, Yi Xiong, Dong-Qing Wei
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Membrane transport proteins play crucial roles in the pharmacokinetics of substrate drugs, the drug resistance in cancer and are vital to the process of drug discovery, development and anti-cancer therapeutics. However, experimental methods to profil
Externí odkaz: https://doaj.org/article/6844bc5a56384a3f8cd116a8dea6b9d8
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5
Akademický článek
Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex.
Autor: Peng Wei, Lida Xu, Cheng-Dong Li, Fu-De Sun, Long Chen, Tianwei Tan, Shi-Zhong Luo
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105560 (2014)
The DAP12-NKG2C activating immunoreceptor complex is one of the multisubunit transmembrane protein complexes in which ligand-binding receptor chains assemble with dimeric signal-transducing modules through non-covalent associations in their transmemb
Externí odkaz: https://doaj.org/article/09d6aead55e64a388d26c7ee755e56e7
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8
Bringing Structural Implications and Deep Learning-Based Drug Identification for KRAS Mutants
Autor: Aamir Mehmood, Cheng-Dong Li, Qiankun Wang, Aman Chandra Kaushik, Dong-Qing Wei
Publikováno v: Journal of Chemical Information and Modeling. 61:571-586
Colorectal cancer is considered one of the leading causes of death that is linked with the Kirsten Rat Sarcoma (KRAS) harboring codons 13 and 61 mutations. The objective for this study is to search for clinically important codon 61 mutations and anal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6738abf9d598983e40bcb7cc72b040
https://doi.org/10.1021/acs.jcim.0c00488
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9
Structural insights of catalytic mechanism in mutant pyrazinamidase ofMycobacterium tuberculosis
Autor: Syed Shujait Ali, Muhammad Junaid, Dong-Qing Wei, Syed Baber Jamal, Cheng-Dong Li, Arif Ali, Abbas Khan, Shah Saud, Jiayi Li
Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-14
Pyrazinamidase (PZase) is a member of Fe-dependent amidohydrolases that activates pyrazinamide (PZA) into active pyrazinoic acid (POA). PZA, a nicotinamide analogue, is an essential first-line drug...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4114980d863230c30f09484171f040cc
https://doi.org/10.1080/07391102.2020.1761879
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10
G-protein-coupled receptors function as logic gates for nanoparticle binding using systems and synthetic biology approach
Autor: Dong-Qing Wei, Aman Chandra Kaushik, Cheng-Dong Li, Yan Li, Shakti Sahi, Xueying Mao
Publikováno v: Journal of Materials Research. 34:1854-1867
G-protein-coupled receptor 142 (GPR142) belongs to rhodopsin family. GPR142 and GPR119, both Gq-coupled receptors, are expressed in pancreatic β cells of pancreas; their activation eventually leads to triggering of insulin secretion. In this paper,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d894c43eb41882a662a1829afe6cc6
https://doi.org/10.1557/jmr.2018.453
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