Výsledky vyhledávání - "Cheng-Der Yu"

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Autor: Hemanshu S. Shah, Bhiku Patel, Pamela Pasciak, Kirk J. Leister, Linda M. Kozick, Cheng-Der Yu, Roger K. Vanderlaan, Elizabeth L Tan

Publikováno v: Pharmaceutical Research. 10:1238-1242

The selection of an ideal semisolid vehicle for growth factors presents a challenge. Some antimicrobial agents are known to delay wound healing. The objective of this investigation was to identify appropriate preservatives and vehicles for TGF-α. Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce7c1bb82eb25e0627f4066a70264e8c
https://doi.org/10.1023/a:1018940907187

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Effect of sugars on freeze-thaw and lyophilization of liposomes

Autor: Jennifer S. Degroot, Cheng-Der Yu, Sriram Vemuri, Seresh Venkataram, Vuthichai Wangsatornthnakun

Publikováno v: Drug Development and Industrial Pharmacy. 17:327-348

Various sugars were investigated for their ability to protect liposomes against fusion and leakage during freeze-and-thaw or lyophilization processes. Size of liposome was measured before and after the events with a light scattering technique. Leakag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a6ba21932201a3bc3a8fe6b485956e3
https://doi.org/10.3109/03639049109043831

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Drug release rate method for a liposome preparation

Autor: Shamim Pushpala, Niek Roosdorp, Sriram Vemuri, Cheng-Der Yu

Publikováno v: Drug Development and Industrial Pharmacy. 17:183-192

An in vitro method was developed to determine the rate of drug release from a liposome formulation. Liposome formulation containing metaproterenol sulfate was evaluated for release of the drug over a 24-hour period in an end-over-end tumbler device.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1509709ea8c9c98bbf9440b59ab2aa7e
https://doi.org/10.3109/03639049109043818

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In Vitro Interaction of Sized and Unsized Liposome Vesicles with High Density Lipo Proteins

Autor: Sriram Vemuri, Cheng-Der Yu, Niek Roosdorp, Jennifer S. Degroot

Publikováno v: Drug Development and Industrial Pharmacy. 16:1579-1584

An in vitro method of interaction of liposome vesicles with high density lipoproteins (HDL) was studied. A formulation of lipids was hydrated, and homogenized with a high shear mixer and designed as “unsized” liposomes. A portion of this preparat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09ef6731d96e5e203967a0f991c5d15a
https://doi.org/10.3109/03639049009074385

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Large-Scale Production of Liposomes by A Microfluidizer

Autor: Sriram Vemuri, Cheng-Der Yu, Niek Roosdorp, Vuthichai Wangsatorntanakun

Publikováno v: Drug Development and Industrial Pharmacy. 16:2243-2256

Liposomes can be produced by a variety of techniques such as sonication, high-pressure homogenization, detergent dialysis, reverse-phase evaporation and ether injection. The Microfluidizer is a high-pressure homogenizer which is capable of making sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e87d8b782b6b2e78656585adfbfdacc
https://doi.org/10.3109/03639049009043797

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Enhancement of Solubility, Dissolution Rate, and Oral Bioavailability of Rs-82856 by Complex Formation with Cyclodextrins

Autor: Ian J. Massey, George J. L. Lee, Cheng Der Yu, Stephanie A. Sweetana, Nancy Chu

Publikováno v: Drug Development and Industrial Pharmacy. 15:609-620

RS-82856 is a new inotropic agent for treatment of congestive heart failure. Oral bioavailability was found to be very poor likely due to insufficient aqueous solubility (∼ 4.4 mcg/ml) and slow dissolution rate. Inclusion complexes with cyclodextri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f8af7cb7e6d5086d4205e5f8386fb71
https://doi.org/10.3109/03639048909040233

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Physical Model Evaluation of Topical Prodrug Delivery—simultaneous Transport and Biocnversion of Vidarabine-5′-valerate II: Parameter Determinations

Autor: Jeffrey L. Fox, Cheng der Yu, Norman F.H. Ho, William I. Higuchi

Publikováno v: Journal of Pharmaceutical Sciences. 68:1347-1357

Results of initial studies on methods for determining various model parameters are reported. By employing excised hairless mouse skin in a diffusion cell system, numerous model parameter values were deduced. The stratum corneum permeability was estim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb454f106cc4265dcc25382f471c9d34
https://doi.org/10.1002/jps.2600681105

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