Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Cheng-Chang Lien"'
Publikováno v:
Journal of Physiological Investigation, Vol 67, Iss 5, Pp 258-269 (2024)
The hippocampus plays a crucial role in learning, memory, and emotion, with the dentate gyrus (DG) serving as the primary gateway. The DG receives multimodal sensory inputs from outside the hippocampus and relays this integrated information to downst
Externí odkaz:
https://doaj.org/article/7d6f833b0278458c971def36652bd7fa
Autor:
Pu-Yeh Wu, Cheng-Chang Lien
Publikováno v:
Journal of Physiological Investigation, Vol 67, Iss 5, Pp 242-248 (2024)
Interstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and memory. H
Externí odkaz:
https://doaj.org/article/06c07242aff04f3888c5174938c3efe2
Autor:
Cheng-Chang Lien, Pei-Chen Wu
Publikováno v:
Sensors, Vol 24, Iss 20, p 6612 (2024)
Traditional object counting systems use object detection methods to count objects. However, when objects are small, crowded, and dense, object detection may fail, leading to inaccuracies in counting. To address this issue, we propose a crowded object
Externí odkaz:
https://doaj.org/article/fcda533c6bcc497b8e451eff4f7d91a2
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine
Publikováno v:
The Journal of Headache and Pain, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background To investigate specific brain regions and neural circuits that are responsible for migraine chronification. Methods We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitro
Externí odkaz:
https://doaj.org/article/4d73f119ce964fabb2c408a2fb435fd4
Autor:
Pei-Hsin Huang, Tsung-Ying Yang, Chia-Wei Yeh, Sheng-Min Huang, Ho-Ching Chang, Yun-Fen Hung, Wen-Chia Chu, Kuan-Hung Cho, Tzu-Pin Lu, Po-Hsiu Kuo, Li-Jen Lee, Li-Wei Kuo, Cheng-Chang Lien, Hwai-Jong Cheng
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment are causally related to mood disorders. BLM-s (BCL-2-like molecule, small transcript isofor
Externí odkaz:
https://doaj.org/article/0f37c5515f4544bdba7a907e949e0e0f
Autor:
Tzu-Hsuan Huang, Yi-Sian Lin, Chiao-Wan Hsiao, Liang-Yun Wang, Musa Iyiola Ajibola, Wahab Imam Abdulmajeed, Yu-Ling Lin, Yu-Jui Li, Cho-Yi Chen, Cheng-Chang Lien, Cheng-Di Chiu, Irene Han-Juo Cheng
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostati
Externí odkaz:
https://doaj.org/article/f5e31084e68641afac963fc78b986bd5
Autor:
Xin Jin, Jian Xie, Chia-Wei Yeh, Jen-Chi Chen, Chih-Jen Cheng, Cheng-Chang Lien, Chou-Long Huang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Maintaining internal osmolality constancy is essential for life. Release of arginine vasopressin (AVP) in response to hyperosmolality is critical. Current hypotheses for osmolality sensors in circumventricular organs (CVOs) of the brain focus on mech
Externí odkaz:
https://doaj.org/article/88c834904d0b4678b48994bb0beda76e
Autor:
Yu-Ling Lin, Zhu-Sen Yang, Wai-Yi Wong, Shih-Che Lin, Shuu-Jiun Wang, Shih-Pin Chen, Jen-Kun Cheng, Hui Lu, Cheng-Chang Lien
Publikováno v:
eLife, Vol 11 (2022)
Chronic pain disorders are often associated with negative emotions, including anxiety and depression. The central nucleus of the amygdala (CeA) has emerged as an integrative hub for nociceptive and affective components during central pain development
Externí odkaz:
https://doaj.org/article/c0734f1d1ef54dcf8b64171af58a4c44
Autor:
Ting-Yun Yen, Xu Huang, Duncan Archibald Allan MacLaren, Magdalene Isabell Schlesiger, Hannah Monyer, Cheng-Chang Lien
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110831- (2022)
Summary: The dentate gyrus (DG) receives substantial input from the homologous brain area of the contralateral hemisphere. This input is by and large excitatory. Viral-tracing experiments provided anatomical evidence for the existence of GABAergic co
Externí odkaz:
https://doaj.org/article/c61eed7b8a40426eacf81e871b8670a0
Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila
Autor:
Kuan-Lin Feng, Ju-Yun Weng, Chun-Chao Chen, Mohammed Bin Abubaker, Hsuan-Wen Lin, Ching-Che Charng, Chung-Chuan Lo, J. Steven de Belle, Tim Tully, Cheng-Chang Lien, Ann-Shyn Chiang
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103506- (2021)
Summary: Long-term memory (LTM) formation requires consolidation processes to overcome interfering signals that erode memory formation. Olfactory memory in Drosophila involves convergent projection neuron (PN; odor) and dopaminergic neuron (DAN; rein
Externí odkaz:
https://doaj.org/article/cf69f5907c0e4ed6a3bfe10fc136abb1