Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Cheng Yao Chiang"'
1
Akademický článek
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
Autor: Yaogang Zhong, Feng Geng, Logan Mazik, Xinmin Yin, Aline Paixao Becker, Shabber Mohammed, Huali Su, Enming Xing, Yongjun Kou, Cheng-Yao Chiang, Yunzhou Fan, Yongchen Guo, Qiang Wang, Pui-Kai Li, Xiaokui Mo, Etienne Lefai, Liqing He, Xiaolin Cheng, Xiang Zhang, Arnab Chakravarti, Deliang Guo
Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101706- (2024)
Summary: Antipsychotic drugs have been shown to have antitumor effects but have had limited potency in the clinic. Here, we unveil that pimozide inhibits lysosome hydrolytic function to suppress fatty acid and cholesterol release in glioblastoma (GBM
Externí odkaz: https://doaj.org/article/19761d521bc9430d9999b8b10ef7bd69
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2
Akademický článek
Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
Autor: Cheng-Yao Chiang, Songqing Fan, Hongmei Zheng, Wenjun Guo, Zehan Zheng, Yihua Sun, Chuanqi Zhong, Juan Zeng, Shuaihu Li, Min Zhang, Tian Xiao, Duo Zheng
Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113003- (2023)
Summary: Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity remain largely unclear
Externí odkaz: https://doaj.org/article/59d0d81c26bc4304bd1ffb60ae523376
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3
Akademický článek
The significance of SMARCB1 in the pathogenesis of renal cell carcinoma with rhabdoid features
Autor: Yi-Wen Wang, Hsiang-Lin Song, Cheng-Yao Chiang, Hong-Fang Song, Hong-Yi Chang, Chien-An Chu, Yih-Lin Tuan, Kun-Hao Tsai, Yin-Chien Ou, Nan-Haw Chow, Yuh-Shyan Tsai
Publikováno v: Translational Oncology, Vol 14, Iss 10, Pp 101175- (2021)
Background: Renal cell carcinoma with rhabdoid features (RCC-RF) is an aggressive histologic variant in the adults and is usually unresponsive to standard chemotherapy. Methods: Expression of SMARCB1/INI1 was examined in primary RCC-RF (n = 5). Stabl
Externí odkaz: https://doaj.org/article/5f6d3ffaf22047a7b27c0ec5810bd923
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4
Akademický článek
Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance
Autor: Daiyong Deng, Riya Patel, Cheng-Yao Chiang, Pingping Hou
Publikováno v: Cells, Vol 11, Iss 19, p 2952 (2022)
Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize
Externí odkaz: https://doaj.org/article/b09128ebb48d4fc8921cace6262f1b27
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