Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea

Autor: Michael Marks, PhD, Oriol Mitjà, PhD, Christian Bottomley, PhD, Cynthia Kwakye, PhD, Wendy Houinei, DPH, Mathias Bauri, MPH, Paul Adwere, MPH, Abdul A Abdulai, MPH, Fredrick Dua, MD, Laud Boateng, MPH, James Wangi, MD, Sally-Ann Ohene, MPH, Regina Wangnapi, MD, Shirley V Simpson, MPhil, Helen Miag, HEO, Kennedy K Addo, ProfPhD, Laud A Basing, MPhil, Damien Danavall, BSc, Kai H Chi, MSc, Allan Pillay, PhD, Ronald Ballard, ProfPhD, Anthony W Solomon, PhD, Cheng Y Chen, PhD, Sibauk V Bieb, MAHM, Yaw Adu-Sarkodie, ProfPhD, David C W Mabey, ProfFRCP, Kingsley Asiedu, MPH, Michael Marks, Oriol Mitjà, Christian Bottomley, Cynthia Kwakye, Wendy Hounei, Mathias Bauri, Paul Adwere, Abdul A Abdulai, Fredrick Dua, Laud Boateng, James Wangi, Sayy-Ann Ohene, Regina Wangnapi, Shirley V Simpson, Helen Miag, Kennedy K Addo, Laud A Basing, Damien Danavall, Kai H Chi, Allan Pillay, Ronald Ballard, Anthony W Solomon, Cheng Y Chen, Sivuak V Bieb, Yaw Adu-Sarkodie, David CW Mabey, Kingsley Asiedu, Nsire Agana, Edwin Ampadu, Kwame Amponsah-Achiano, Asare Bediako, Michael Biredu, Kyei Faried, Ahmed Iddrisu, Nana K Kotey, George NY Yeboah, Philip El-Duah, Richard Phillips, Fred Binka, Frank Nyonator, Anthony Zunuo, Mercy A Ackumey, Ivy Amanor, Christian Bnosu, Sieghard Frischmann, Patrick Lammie, Diana Martin, Tun Ye, Eva Christophel, Alexandre Tiendrebeogo, Lasse Vestergard, Quique Bassat, Yazid Abdad, Henson Dima, Bethuel Kotty, Kaiok Mamore, Walerius Manup, Benson Olowau, Enoch O Agyei, David Agyemang, Ebenezer P Ako, Prince Antwi, Jane Darko, Ophelia O Darko, Phylis Darko, Bertha Duodu, Daniel Jabasi, Fuseini L Karim, Obed K Koomson, Bernard A Labri, John Nartey, Randsford Tamatey, Benjamin Yirenkyi, Mercy Arhin, Frank Biney, Juliana O Danso, Martin A Dei, Moses Djan, Samuel Sasu, Brefo A Solomon, Victor Torvinya, Hagar Amankwaah, James Baffoe, Lydia Keteku, Kofi Kondobala, Rita D Lomotey, Augustina A Nartey, Paul Oppong, Millicent A Quainoo, Theophilus Abotsi, Dzighordi Agebshie, Amos Ameamu, Paul Angwaawie, Rose Ayibor, Margaret Mwingmendeli, John Nakodia, Amatus Nambagyira, Dominic Nanga, Nichola Tetteh, Augustine Wanaom

Publikováno v: The Lancet Global Health, Vol 6, Iss 4, Pp e401-e410 (2018)

Summary: Background: A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem

Externí odkaz: https://doaj.org/article/80d8729e29194b8a92aac058ab687ea6

Molecular strain typing of the yaws pathogen, Treponema pallidum subspecies pertenue.

Autor: Samantha S Katz, Kai-Hua Chi, Eli Nachamkin, Damien Danavall, Fasihah Taleo, Jacob L Kool, Kennedy Kwasi Addo, William Ampofo, Shirley V Simpson, Tun Ye, Kingsley B Asiedu, Ronald C Ballard, Cheng Y Chen, Allan Pillay

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203632 (2018)

Yaws is a neglected tropical disease caused by the bacterium Treponema pallidum subspecies pertenue. The disease primarily affects children under 15 years of age living in low socioeconomic conditions in tropical areas. As a result of a renewed focus

Externí odkaz: https://doaj.org/article/4cfb92792a1b43bdab8fa070d29dec23

Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws.

Autor: Michael Marks, Samantha Katz, Kai-Hua Chi, Ventis Vahi, Yongcheng Sun, David C Mabey, Anthony W Solomon, Cheng Y Chen, Allan Pillay

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003905 (2015)

Yaws, caused by Treponema pallidum ssp. pertenue, is a neglected tropical disease closely related to venereal syphilis and is targeted for eradication by 2020. Latent yaws represents a diagnostic challenge, and current tools cannot adequately disting

Externí odkaz: https://doaj.org/article/16e2859f669b48b6a8cb8282be8f61bd

O07.3 Molecular investigation of Treponema pallidum strains associated with ocular syphilis in the United States

Autor: Allan Pillay, Damien Danavall, Cheng Y. Chen, Samantha S. Katz, Kai-Hua Chi, K Vilfort, R Barrow, Thurlow Cm, Kimberly A. Workowski, A Debra, Ellen N. Kersh, Sandeep J. Joseph

Publikováno v: Syphilis epidemiology.

Background Ocular syphilis cases continue to be identified in the United States since two clusters were reported in late 2014 into early 2015. Ocular syphilis (OS) is an inflammatory eye condition that can occur at any stage of syphilis with vision l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe46de5dda5e355a096296950025fa62
https://doi.org/10.1136/sextrans-2021-sti.88

Antibody Responses to Two Recombinant Treponemal Antigens (rp17 and TmpA) before and after Azithromycin Treatment for Yaws in Ghana and Papua New Guinea

Autor: Diana L. Martin, Cheng Y. Chen, Christian Bottomley, Nishanth Parameswaran, Michael Marks, Ronald C. Ballard, Sibauk Bieb, Kingsley Asiedu, Yaw Adu-Sarkodie, Allan Pillay, David Mabey, Wendy Houinei, Cynthia Kwakye, Anthony W. Solomon, Kai-Hua Chi, Damien Danavall, Oriol Mitjà

Publikováno v: J Clin Microbiol
Journal of Clinical Microbiology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

WHO and its partners aim to interrupt yaws transmission in countries of endemicity and to certify others as being yaws-free. Transmission can be assessed using rapid plasma reagin (RPR) tests, reflecting current or recent infection, but RPR is operat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375187cf1775300984b4b4eb8405a6f
https://pubmed.ncbi.nlm.nih.gov/33568467