Uncharacterized yeast gene YBR238C , an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4 - and RMD9 -dependent mechanisms.

Autor: Alfatah M; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim JJJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhang Y; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Naaz A; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Cheng TYN; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yogasundaram S; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Faidzinn NA; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lin JJ; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Eisenhaber B; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; LASA - Lausitz Advanced Scientific Applications gGmbH, Weißwasser, Germany., Eisenhaber F; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; LASA - Lausitz Advanced Scientific Applications gGmbH, Weißwasser, Germany.; School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore, Singapore.

Publikováno v: ELife [Elife] 2024 May 07; Vol. 12. Date of Electronic Publication: 2024 May 07.

Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae.

Autor: Alfatah M; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore. Electronic address: alfatahm@bii.a-star.edu.sg., Cui L; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Singapore 138602, Singapore., Goh CJH; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore., Cheng TYN; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore., Zhang Y; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore., Naaz A; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore., Wong JH; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore., Lewis J; Institute of Molecular and Cellular Biology, 61 Biopolis Drive, Singapore 138673, Singapore., Poh WJ; Bioinformatics Institute, A(∗)STAR, 30 Biopolis Street, Singapore 138671, Singapore., Arumugam P; Singapore Institute of Food and Biotechnology Innovation, A(∗)STAR, 31 Biopolis Way, Singapore 138669, Singapore; Nanyang Technological University, School of Biological Sciences, Singapore 637551, Singapore. Electronic address: parumugam@sifbi.a-star.edu.sg.

Publikováno v: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113205. Date of Electronic Publication: 2023 Oct 04.