Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Cheng J. Ma"'
Autor:
Cheng J Ma, Jun P Ren, Guang Y Li, Xiao Y Wu, Dirk G Brockstedt, Peter Lauer, Jonathan P Moorman, Zhi Q Yao
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87821 (2014)
In this study, we engineered Listeria monocytogens (Lm) by deleting the LmΔactA/ΔinlB virulence determinants and inserting HCV-NS5B consensus antigens to develop a therapeutic vaccine against hepatitis C virus (HCV) infection. We tested this recomb
Externí odkaz:
https://doaj.org/article/b77d27cafb5d4771b2591c8646fd8eca
Autor:
Cheng J Ma, Guang Y Li, Yong Q Cheng, Jia M Wang, Ruo S Ying, Lei Shi, Xiao Y Wu, Toshiro Niki, Mitsumi Hirashima, Chuan F Li, Jonathan P Moorman, Zhi Q Yao
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72488 (2013)
Human monocytes/macrophages (M/M(Ф)) of the innate immunity sense and respond to microbial products via specific receptor coupling with stimulatory (such as TLR) and inhibitory (such as Tim-3) receptors. Current models imply that Tim-3 expression on
Externí odkaz:
https://doaj.org/article/c4c46906c0644f28a303916cdbc9c78f
Autor:
Ying Zhang, Cheng J Ma, Jia M Wang, Xiao J Ji, Xiao Y Wu, Zhan S Jia, Jonathan P Moorman, Zhi Q Yao
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19664 (2011)
T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up-regulated on dysfunctional T cells during viral infections. The expression and function of Tim-3 on human innate immune resp
Externí odkaz:
https://doaj.org/article/e576329dad0847cca6c4335c7b47adc5
Autor:
Zhi Q. Yao, Ke S. Wang, Xiao J. Ji, Jonathan P. Moorman, Lei Shi, Xiao Y. Wu, Guangyu Li, Cheng J. Ma, Ruo S. Ying, Jia M. Wang
Publikováno v:
Journal of Virology. 87:4372-4383
Cytokine production by innate immunity is critical for shaping the adaptive immunity through regulation of T cell differentiation. In this report, we studied T cell immunoglobulin mucin domain protein 3 (Tim-3) expression on monocytes and its regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3147174169b69419095307be48b6ac4
https://doi.org/10.1128/jvi.03376-12
https://doi.org/10.1128/jvi.03376-12
Autor:
Xiao J. Ji, Mitsumi Hirashima, Zhi Q. Yao, Jia M. Wang, Cheng J. Ma, Jonathan P. Moorman, Toshiro Niki, Xiao Y. Wu
Publikováno v:
European Journal of Immunology. 43:458-467
HCV is remarkable at disrupting human immunity to establish chronic infection. The accumulation of Treg cells at the site of infection and upregulation of inhibitory signaling pathways (such as T-cell Ig and mucin domain protein-3 (Tim-3) and galecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12033dfb19d5ab6ac59bdb2665aedd5e
https://doi.org/10.1002/eji.201242768
https://doi.org/10.1002/eji.201242768
Autor:
Xiao Y. Wu, Cheng J. Ma, Zhan S. Jia, Jia M. Wang, Zhi Q. Yao, Xiao J. Ji, Jonathan P. Moorman, Ke S. Wang, Ying Zhang
Publikováno v:
The Journal of Immunology. 189:755-766
Hepatitis C virus (HCV) is remarkable at disrupting human immunity to establish chronic infection. Upregulation of inhibitory signaling pathways (such as T cell Ig and mucin domain protein-3 [Tim-3]) and accumulation of regulatory T cells (Tregs) pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a03b662fac00bf45f3bfe14effcf072
https://doi.org/10.4049/jimmunol.1200162
https://doi.org/10.4049/jimmunol.1200162
Autor:
Lei Ni, Jonathan P. Moorman, Xiao Y. Wu, Chun L. Zhang, Cheng J. Ma, Thomas Borthwick, Tareq M. Islam, Ying Zhang, Zhi Q. Yao, Penny Thayer
Publikováno v:
Vaccine. 29:3169-3176
Vaccination for hepatitis B virus (HBV) in the setting of hepatitis C virus (HCV) infection is recommended, but responses to vaccination are blunted when compared to uninfected populations. The mechanism for this failure of immune response in HCV-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5d4728a79ccbef6d3ea654765d8f72
https://doi.org/10.1016/j.vaccine.2011.02.052
https://doi.org/10.1016/j.vaccine.2011.02.052
Autor:
Uday Kumaraguru, Lei Ni, Chuan F. Li, Jonathan P. Moorman, Cheng J. Ma, Xiao Y. Wu, Chun L. Zhang, Zhi Q. Yao, Ying Zhang
Publikováno v:
The Journal of Immunology. 186:3093-3103
Hepatitis C virus (HCV) dysregulates innate immune responses and induces persistent viral infection. We previously demonstrated that HCV core protein impairs IL-12 expression by monocytes/macrophages (M/MΦs) through interaction with a complement rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5602242b3f4439cf6325f4eafbfa57f2
https://doi.org/10.4049/jimmunol.1002006
https://doi.org/10.4049/jimmunol.1002006
Autor:
Ying Zhang, Penny Thayer, Ashley D. Frazier, Cheng J. Ma, Jonathan P. Moorman, Xiao Y. Wu, Xin Y Chen, Zhi P Dong, Lei Ni, Zhi Q. Yao, Chun L. Zhang, Thomas Borthwick
Publikováno v:
Immunological Investigations. 40:243-264
HCV infection is associated with immune dysregulation and B cell Non-Hodgkins lymphoma (HCV-NHL). We have previously shown in vitro that HCV core protein differentially regulates T and B cell functions through two negative signaling pathways, program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91b22abe0dc7254202f6219bc5269ef
https://doi.org/10.3109/08820139.2010.534218
https://doi.org/10.3109/08820139.2010.534218
Autor:
Jonathan P. Moorman, Lei Ni, Chun L. Zhang, Ying Zhang, Penny Thayer, Cheng J. Ma, Antwan N. Atia, Xiao Y. Wu, Zhi Q. Yao
Publikováno v:
Immunology. 132:421-431
Hepatitis C virus (HCV) is remarkably efficient at evading host immunity to establish chronic infection. During chronic HCV infection, interleukin-12 (IL-12) produced by monocytes/macrophages (M/Mφ) is significantly suppressed. Programmed death-1 (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c8fc7fe9a585cd88db21c42e39c12a
https://doi.org/10.1111/j.1365-2567.2010.03382.x
https://doi.org/10.1111/j.1365-2567.2010.03382.x