Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Cheng‐Xin Gong"'
Autor:
Nana Jin, Jianlan Gu, Ruozhen Wu, Dandan Chu, Yunn Chyn Tung, Jerzy Wegiel, Thomas Wisniewski, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Propagation of tau pathology via the seeding of naive tau aggregation underlies the progression of Alzheimer’s disease (AD) and related tauopathies. Individuals with Down syndrome (DS) develop tau pathology at the fourth decade of life, bu
Externí odkaz:
https://doaj.org/article/d374f4940eeb403790e9f50b07df8939
Autor:
Fei Liu, Ruozhen Wu, Nana Jin, Dandan Chu, Jianlan Gu, Yunn Chyn Tung, Zhihao Hu, Cheng-Xin Gong, Khalid Iqbal
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The regional distribution of neurofibrillary tangles of hyperphosphorylated tau aggregates is associated with the progression of Alzheimer’s disease (AD). Misfolded proteopathic tau recruits naïve tau and templates its misfolding and aggregation i
Externí odkaz:
https://doaj.org/article/e752612289d7476dafaf56c7e75bd1a0
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/4991ad6d68df4023b119a4feab408e23
Autor:
Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Neurofibrillary tangles (NFTs) made of abnormally hyperphosphorylated tau are a hallmark of Alzheimer’s disease (AD) and related tauopathies. Regional distribution of NFTs is associated with the progression of the disease and has been prop
Externí odkaz:
https://doaj.org/article/9e26ae6fedb94184b7615599f93b7355
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Background Recent studies indicated that circulatory factors in blood plasma from young animals can reactivate neurogenesis, restore synaptic plasticity, and improve cognitive function in aged animals. Here, we investigated if young plasma c
Externí odkaz:
https://doaj.org/article/c9af95ef77c140448a5af43a10ee212a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that eventually leads to dementia and death of the patient. Despite the enormous amounts of resources and efforts for AD drug development during the last three decades, no effecti
Externí odkaz:
https://doaj.org/article/7bd227b6cb844c0e8aea70ea454eb6c2
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231090 (2020)
Sevoflurane and isoflurane are among the most commonly used general anesthetics for children including infants, but their impact on metabolism, especially on blood glucose level, in children is not well understood. We investigated the impacts of anes
Externí odkaz:
https://doaj.org/article/520804b071804d3b9d04f8dd53cd2ae4
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Accumulating evidence indicates that Tau pathology can spread from neuron to neuron by intake and coaggregation of the hyperphosphorylated Tau (p-Tau) seeds with the host neuron protein. Thus, clearance of Tau seeds by immunizatio
Externí odkaz:
https://doaj.org/article/afa6f073703e4738b829213c4629656c
Autor:
Xiaomin Yin, Nana Jin, Jianhua Shi, Yanchong Zhang, Yue Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain. Imbalanced expression in 3R-tau and 4R-tau has been found in sever
Externí odkaz:
https://doaj.org/article/55ff45703dc84a5690b2e8a8fb95cd0b
Autor:
Hengchang Li, Chun-ling Dai, Jin-Hua Gu, Shengwei Peng, Jian Li, Qian Yu, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Children, after multiple exposures to general anesthesia, appear to be at an increased risk of developing learning disabilities. Almost all general anesthetics—including sevoflurane, which is commonly used for children—are potentially neurotoxic
Externí odkaz:
https://doaj.org/article/7aff22868bc84316b96e59d05baea62c