Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Cheng‐Shi Jiang"'
Autor:
Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan
Publikováno v:
MedComm, Vol 4, Iss 2, Pp n/a-n/a (2023)
Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human cancers, including in ovarian cancer. However, the exactly roles and un
Externí odkaz:
https://doaj.org/article/8c1a0d509b124df5ae4a85577bce88bb
Autor:
Shan-Kui Liu, Haifang Hao, Yuan Bian, Yong-Xi Ge, Shengyuan Lu, Hong-Xu Xie, Kai-Ming Wang, Hongrui Tao, Chao Yuan, Juan Zhang, Jie Zhang, Cheng-Shi Jiang, Kongkai Zhu
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of type 2 diabetes. In the present study, 52 candidates of α-glycosidase inhibitors were selec
Externí odkaz:
https://doaj.org/article/65701e9d48c6455ab9e53c5ef9f36d73
Autor:
Tong-Xin Zong, Ariane Pandolfo Silveira, José Athayde Vasconcelos Morais, Marina Carvalho Sampaio, Luis Alexandre Muehlmann, Juan Zhang, Cheng-Shi Jiang, Shan-Kui Liu
Publikováno v:
Nanomaterials, Vol 12, Iss 11, p 1855 (2022)
Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organi
Externí odkaz:
https://doaj.org/article/c6bca7f57d3948d1bdf145d64427dcbb
Autor:
Cheng-Shi Jiang, Chun-Lin Zhuang, Kongkai Zhu, Juan Zhang, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Ricardo Bentes Azevedo, Wen Zhang, Ning Meng, Hua Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 833-841 (2018)
A new Keap1–Nrf2 protein–protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation. ZJ01 could in vitro tri
Externí odkaz:
https://doaj.org/article/5ef3c3e0dbca4fbcb20f4af2f213d99f
Publikováno v:
Molecules, Vol 25, Iss 2, p 419 (2020)
The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstit
Externí odkaz:
https://doaj.org/article/c732bb06e0164e799ed3ecc832d4261c
Autor:
Cheng-Shi Jiang, Yong-Xi Ge, Zhi-Qiang Cheng, Yin-Yin Wang, Hong-Rui Tao, Kongkai Zhu, Hua Zhang
Publikováno v:
Molecules, Vol 24, Iss 14, p 2568 (2019)
In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and synthesized from the structural optimization of hit 1, a 4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzoic acid derivative identified by virtual screening
Externí odkaz:
https://doaj.org/article/c07b82f867e84384ac7d3ae0da552454
Publikováno v:
Molecules, Vol 24, Iss 14, p 2569 (2019)
A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC50 values, with the best compound (10e) being nearly 90 t
Externí odkaz:
https://doaj.org/article/eacc7cd0717f47bca3c9815da27bac48
Autor:
Jie Bao, Fei He, Jin-Hai Yu, Huijuan Zhai, Zhi-Qiang Cheng, Cheng-Shi Jiang, Yuying Zhang, Yun Zhang, Xiaoyong Zhang, Guangying Chen, Hua Zhang
Publikováno v:
Molecules, Vol 23, Iss 8, p 1982 (2018)
Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses
Externí odkaz:
https://doaj.org/article/33073fa0b12b4fdb9fac3fa331deee05
Publikováno v:
Molecules, Vol 23, Iss 8, p 1972 (2018)
A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs 5p and 5q showed promising antiproliferative activity against a panel of cancer cell lines, including A549,
Externí odkaz:
https://doaj.org/article/d0aa5cf011df45e886c0e95dc3e35f04
Publikováno v:
Marine Drugs, Vol 16, Iss 9, p 293 (2018)
A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (
Externí odkaz:
https://doaj.org/article/37a9bb3a17294e2ca245df00fbdef97f