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Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.

Autor: Bruedigam C; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Claudia.Bruedigam@QIMRBerghofer.edu.au.; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia. Claudia.Bruedigam@QIMRBerghofer.edu.au., Porter AH; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Song A; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Vroeg In de Wei G; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Stoll T; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Straube J; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia., Cooper L; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Cheng G; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Kahl VFS; Telomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia., Sobinoff AP; Telomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia., Ling VY; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Jebaraj BMC; Division of CLL, Department of Internal Medicine III, Ulm University, Ulm, Germany., Janardhanan Y; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Haldar R; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Bray LJ; Faculty of Engineering, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, Queensland, Australia., Bullinger L; Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany., Heidel FH; Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany.; Leibniz Institute on Aging, Jena, Germany., Kennedy GA; Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Hill MM; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Pickett HA; Telomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia., Abdel-Wahab O; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hartel G; Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Lane SW; Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Steven.Lane@QIMRBerghofer.edu.au.; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia. Steven.Lane@QIMRBerghofer.edu.au.; Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. Steven.Lane@QIMRBerghofer.edu.au.

Publikováno v: Nature cancer [Nat Cancer] 2024 Jan; Vol. 5 (1), pp. 47-65. Date of Electronic Publication: 2023 Oct 30.