Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Chenfu Shi"'
Autor:
Mauro Tutino, Jenny Hankinson, Clare Murray, Lesley Lowe, Gina Kerry, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston, Chenfu Shi, Gisela Orozco, Stephen Eyre, Paul Martin, Angela Simpson, John A. Curtin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that CD4+ T-cells play an important role in asthma pathogenesis. Despite this, CD4+ T-cells are under-represented in asthma transcriptome
Externí odkaz:
https://doaj.org/article/c7ac37edc530414aabe9f0ab3891436c
Autor:
Xiangyu Ge, Mojca Frank-Bertoncelj, Kerstin Klein, Amanda McGovern, Tadeja Kuret, Miranda Houtman, Blaž Burja, Raphael Micheroli, Chenfu Shi, Miriam Marks, Andrew Filer, Christopher D. Buckley, Gisela Orozco, Oliver Distler, Andrew P. Morris, Paul Martin, Stephen Eyre, Caroline Ospelt
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-39 (2021)
Abstract Background Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded stromal cells, such a
Externí odkaz:
https://doaj.org/article/8cd52096d8e14ee7b73e6f6f9def48f2
Autor:
Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the fin
Externí odkaz:
https://doaj.org/article/fc874bf79d974ecf8ffc27cc8532e984
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0223939 (2020)
Whilst susceptibility variants for many complex diseases, such as rheumatoid arthritis (RA), have been well characterised, the mechanism by which risk is mediated is still unclear for many loci. This is especially true for the majority of variants th
Externí odkaz:
https://doaj.org/article/fdc9a834b4b74ae39a3096f61892ae0a
Autor:
Yanshan Liu, Siddharth Banka, Yingzhi Huang, Jonathan Hardman-Smart, Derek Pye, Antonio Torrelo, Glenda M. Beaman, Marcelo G. Kazanietz, Martin J. Baker, Carlo Ferrazzano, Chenfu Shi, Gisela Orozco, Stephen Eyre, Michel van Geel, Anette Bygum, Judith Fischer, Zosia Miedzybrodzka, Faris Abuzahra, Albert Rübben, Sara Cuvertino, Jamie M. Ellingford, Miriam J. Smith, D. Gareth Evans, Lizelotte J.M.T. Weppner-Parren, Maurice A.M. van Steensel, Iskander H. Chaudhary, D. Chas Mangham, John T. Lear, Ralf Paus, Jorge Frank, William G. Newman, Xue Zhang
Publikováno v:
British Journal of Dermatology, 187(6), 948-961. Wiley
Background Bazex–Dupré–Christol syndrome (BDCS; MIM301845) is a rare X-linked dominant genodermatosis characterized by follicular atrophoderma, congenital hypotrichosis and multiple basal cell carcinomas (BCCs). Previous studies have linked BDCS
Autor:
David González‐Serna, Chenfu Shi, Martin Kerick, Jenny Hankinson, James Ding, Amanda McGovern, Mauro Tutino, Gonzalo Villanueva‐Martin, Norberto Ortego‐Centeno, José Luis Callejas, Javier Martin, Gisela Orozco
Publikováno v:
Arthritis & Rheumatology.
Autor:
David González-Serna, Chenfu Shi, Martin Kerick, Jenny Hankinson, James Ding, Amanda McGovern, Mauro Tutino, Gonzalo Villanueva Martin, Norberto Ortego-Centeno, José Luis Callejas, Javier Martin, Gisela Orozco
Publikováno v:
Rheumatology. 62
Background/Aims Genome-wide association studies studies have identified many genetic variants associated with the risk of developing common rheumatological conditions. These variants primarily affect regulatory elements of the genome which can affect
Autor:
David González-Serna, Chenfu Shi, Martin Kerick, Jenny Hankinson, James Ding, Amanda McGovern, Mauro Tutino, Gonzalo Villanueva Martin, Norberto Ortego-Centeno, José Luis Callejas, Javier Martin, Gisela Orozco
Publikováno v:
González-Serna, D, Shi, C, Kerick, M, Hankinson, J, Ding, J, McGovern, A, Tutino, M, Villanueva Martin, G, Ortego-Centeno, N, Callejas, J L, Martin, J & Orozco, G 2022, ' Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis risk ', Arthritis & rheumatology (Hoboken, N.J.) . https://doi.org/10.1002/art.42396
ObjectivesSystemic sclerosis (SSc) is a complex autoimmune disease with a strong genetic component. However, most of the genes associated to the disease are still unknown because associated variants affect mostly non-coding intergenic elements of the
Autor:
Yanshan Liu, Siddharth Banka, Yingzhi Huang, Jonathan Hardman-Smart, Derek Pye, Antonio Torrelo, Glenda M. Beaman, Marcelo G. Kazanietz, Martin J Baker, Carlo Ferrazzano, Chenfu Shi, Gisela Orozco, Stephen Eyre, Michel van Geel, Anette Bygum, Judith Fischer, Zosia Miedzybrodzka, Faris Abuzahra, Albert Rübben, Sara Cuvertino, Jamie M. Ellingford, Miriam J. Smith, D. Gareth Evans, Lizelotte J.M.T Weppner-Parren, Maurice A.M. van Steensel, Iskander H. Chaudhary, D. Chas Mangham, John T. Lear, Ralf Paus, Jorge Frank, William G. Newman, Xue Zhang
BackgroundBazex-Dupré-Christol syndrome (BDCS; MIM301845) is a rare X-linked dominant genodermatosis characterized by follicular atrophoderma, congenital hypotrichosis and multiple basal cell carcinomas (BCCs). Previous studies have linked BDCS to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f771ae001418a78ce8b7b617e700c3ed
https://doi.org/10.1101/2022.02.12.22270762
https://doi.org/10.1101/2022.02.12.22270762
Autor:
Richard B. Warren, Jenny Hankinson, Patrick M. Gaffney, Magnus Rattray, Oliver Gough, Stephen Eyre, Gisela Orozco, Kate Duffus, Annie Yarwood, Chenfu Shi, Yao Fu, James Ding, Amanda McGovern, Paul Martin, Helen Ray-Jones, Vasanthipriyadarshini Gaddi
Publikováno v:
Shi, C, Ray-Jones, H, Ding, J, Duffus, K, Fu, Y, Gaddi, V P, Gough, O, Hankinson, J, Martin, P, McGovern, A, Yarwood, A, Gaffney, P, Eyre, S, Rattray, M, Warren, R B & Orozco, G 2021, ' Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits ', The Journal of Investigative Dermatology, vol. 141, no. 8, pp. 1975-1984 . https://doi.org/10.1016/j.jid.2021.01.015
Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. In this study, we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d10994e884e95df7c74f8f969732cb8
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a