Výsledky vyhledávání - "Cheney, Emily"

Additional file 1 of Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer

Autor: Lal, Jessica Castrillon, Townsend, Madeline G., Mehta, Anita K., Oliwa, Madisson, Miller, Eric, Sotayo, Alaba, Cheney, Emily, Mittendorf, Elizabeth A., Letai, Anthony, Guerriero, Jennifer L.

Additional file 1: Supplemental Figure 1. Immunophenotyping of cells used for generation of syngeneic murine models. Tumors from the MMTV-PyMT autochthonous model were used to generate inoculum to inject into wild type mice to generate 1E6, 1E5 and 1

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Akademický článek

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Additional file 8: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S8. Expression of IFNγ or PD-1 on T cells is not affected shortly after treatment. Peritoneal cells harvested from mice treated with vehicle (Veh); chemotherapy (Chemo); anti-IL-10, 2′3’-cGAMP, and anti-PD-L1 immunotherapy (IT); or both C

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Additional file 3: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S3. Gating strategy used in flow cytometric analysis of immune cells harvested from the peritoneal cavity after treatment. Flow cytometric data were analyzed using FlowJo software. (PDF 423 kb)

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Additional file 4: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S4. Chemotherapy induces an increase in granulocytic but not monocytic MDSCs. Mice were inoculated orthotopically with ID8-Vegf-Defb29 ovarian cancer cells. Eight days later, the mice were injected with vehicle (Veh) or chemotherapy (Chemo). T

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Additional file 2: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S2. Functional enrichment analysis of unsorted cells highlights the importance of the innate immune system. Mice were inoculated with ID8-Vegf-Defb29 cancer cells. Eight days later, mice were injected with either vehicle or paclitaxel and carb

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Additional file 9: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S9. Flow cytometry analysis confirms that CD11b+ myeloid cells, CD8a+ T cells, and CD4+ T cells are depleted following administration of appropriate antibodies. (a) Plots are shown for leukocytes isolated from blood after initiation of treatme

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Additional file 12: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S12. Numbers of NK cells are not affected by combination therapy. Peritoneal cells harvested from mice treated with vehicle (Veh); chemotherapy (Chemo); anti-IL-10, 2′3’-cGAMP, and anti-PD-L1 immunotherapy (IT); or both Chemo and IT (Combo

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Additional file 7: of Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Autor: Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael

Figure S7. Combination therapy increases the proportion of differentiated CD8+ T cells. Peritoneal cells harvested from mice treated with vehicle (Veh); chemotherapy (Chemo); anti-IL-10, 2′3’-cGAMP, and anti-PD-L1 immunotherapy (IT); or both Chem

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