Zobrazeno 1 - 10 of 162 pro vyhledávání: '"Chendil, Damodaran"'
3
Akademický článek
Urolithin A analog inhibits castration-resistant prostate cancer by targeting the androgen receptor and its variant, androgen receptor-variant 7
Autor: Balaji Chandrasekaran, Ashish Tyagi, Uttara Saran, Venkatesh Kolluru, Becca V. Baby, Venkat R. Chirasani, Nikolay V. Dokholyan, Jyh M. Lin, Amandeep Singh, Arun K. Sharma, Murali K. Ankem, Chendil Damodaran
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
We investigated the efficacy of a small molecule ASR-600, an analog of Urolithin A (Uro A), on blocking androgen receptor (AR) and its splice variant AR-variant 7 (AR-V7) signaling in castration-resistant prostate cancer (CRPC). ASR-600 effectively s
Externí odkaz: https://doaj.org/article/3c39b919e8a144f49978bb9232157b3f
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4
Akademický článek
A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
Autor: Uttara Saran, Balaji Chandrasekaran, Ashish Tyagi, Vaibhav Shukla, Amandeep Singh, Arun K. Sharma, Chendil Damodaran
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Although breast cancer stem cells (BCSCs) are well characterized, molecularly targeting and eradicating this sub-population remains a challenge in the clinic. Recent studies have explored several signaling pathways that govern stem cell activation: W
Externí odkaz: https://doaj.org/article/46707c95583d4e34baa3f023ed8082d8
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5
Akademický článek
A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis
Autor: Vaibhav Shukla, Balaji Chandrasekaran, Ashish Tyagi, Ajit Kumar Navin, Uttara Saran, Rosalyn M. Adam, Chendil Damodaran
Publikováno v: Cells, Vol 11, Iss 15, p 2435 (2022)
Arsenic (sodium arsenite: NaAsO2) is a potent carcinogen and a known risk factor for the onset of bladder carcinogenesis. The molecular mechanisms that govern arsenic-induced bladder carcinogenesis remain unclear. We used a physiological concentratio
Externí odkaz: https://doaj.org/article/0c07229ffd9446ba93c680dd8ec183a8
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7
Akademický článek
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
Autor: Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma
Publikováno v: Molecules, Vol 27, Iss 3, p 886 (2022)
Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that
Externí odkaz: https://doaj.org/article/2a94854f6950408d978a824a9214f1be
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8
Akademický článek
Withaferin A Inhibits Prostate Carcinogenesis in a PTEN-deficient Mouse Model of Prostate Cancer
Autor: Jim Moselhy, Suman Suman, Mohammed Alghamdi, Balaji Chandarasekharan, Trinath P. Das, Alatassi Houda, Murali Ankem, Chendil Damodaran
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 6, Pp 451-459 (2017)
We recently demonstrated that AKT activation plays a role in prostate cancer progression and inhibits the pro-apoptotic function of FOXO3a and Par-4. AKT inhibition and Par-4 induction suppressed prostate cancer progression in preclinical models. Her
Externí odkaz: https://doaj.org/article/ac7122ffdc384d80a91d88c92e1d0290
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