Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chenchu Lin"'
Autor:
Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L. Wilson, Ryan Steger, Annabel K. Sangree, Medina Colic, Sidney H. Wang, John G. Doench, Traver Hart
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Genetic interactions mediate the emergence of phenotype from genotype, but technologies for combinatorial genetic perturbation in mammalian cells are challenging to scale. Here, we identify background-independent paralog synthetic lethals fr
Externí odkaz:
https://doaj.org/article/c7711b8dde9c4e0a8d46f98bf7f711db
Autor:
Eiru Kim, Lance C. Novak, Chenchu Lin, Medina Colic, Lori L. Bertolet, Veronica Gheorghe, Christopher A. Bristow, Traver Hart
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate
Externí odkaz:
https://doaj.org/article/bcccc35c18894c27a6cecb11c529d588
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Haley C Dahl, Mohammed Kanchwala, Shayna E Thomas-Jardin, Amrit Sandhu, Preethi Kanumuri, Afshan F Nawas, Chao Xing, Chenchu Lin, Daniel E Frigo, Nikki A Delk
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242970 (2020)
Chronic inflammation promotes prostate cancer (PCa) initiation and progression. We previously reported that acute intereluekin-1 (IL-1) exposure represses androgen receptor (AR) accumulation and activity, providing a possible mechanism for IL-1-media
Externí odkaz:
https://doaj.org/article/cc3a459f52fd4a74a232424063330a37
Autor:
Daniel E. Frigo, Cristian Coarfa, Wajahat Dawood, Diana Jasso, Ratna Mukhopadhyay, Efrosini Tsouko, Yan Shi, Jianrong Dong, Kimal Rajapakshe, Chenchu Lin, Mark A. White
List of siRNA, shRNA and primer sequences used in study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0e766160c13917fde6908758bb9c9e
https://doi.org/10.1158/1541-7786.22510743.v1
https://doi.org/10.1158/1541-7786.22510743.v1
Autor:
Daniel E. Frigo, Cristian Coarfa, Wajahat Dawood, Diana Jasso, Ratna Mukhopadhyay, Efrosini Tsouko, Yan Shi, Jianrong Dong, Kimal Rajapakshe, Chenchu Lin, Mark A. White
These supplementary data demonstrate the androgen biphasic effect (Fig. S1), that SLC1A4 and SLC1A5 are indirect AR target genes (Fig. S2), provide knockdown controls for siRNAs targeting SLC1A4 and SLC1A5 (Fig. S3) and shRNA targeting MYC in stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d0ce0eadafe69a4c2104f254a3c1bf
https://doi.org/10.1158/1541-7786.22510746
https://doi.org/10.1158/1541-7786.22510746
Autor:
Daniel E. Frigo, Cristian Coarfa, Wajahat Dawood, Diana Jasso, Ratna Mukhopadhyay, Efrosini Tsouko, Yan Shi, Jianrong Dong, Kimal Rajapakshe, Chenchu Lin, Mark A. White
Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the processes downstream of AR that drive disease development and progression remain poorly understood. This knowledge gap has thus limited the ability to treat canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54466cd97370736354bb84e1035bc6a0
https://doi.org/10.1158/1541-7786.c.6539715
https://doi.org/10.1158/1541-7786.c.6539715
Autor:
Thomas L. Pulliam, Pavithr Goli, Dominik Awad, Chenchu Lin, Sandi R. Wilkenfeld, Daniel E. Frigo
Publikováno v:
Nature Reviews Urology. 19:367-380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd90795d9305673e06d19e154062e20
https://doi.org/10.1038/s41585-022-00588-z
https://doi.org/10.1038/s41585-022-00588-z
Autor:
Nazanin Esmaeili Anvar, Chenchu Lin, Lori L. Wilson, Annabel K. Sangree, Xingdi Ma, Medina Colic, John G. Doench, Traver Hart
Genetic interactions mediate the emergence of phenotype from genotype, but initial technologies for multiplex genetic perturbation in mammalian cells suffer from inefficiency and are challenging to scale. Recent focus on paralog synthetic lethality i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577f0648bbfefd6a04955707307165c9
https://doi.org/10.1101/2023.01.03.522655
https://doi.org/10.1101/2023.01.03.522655
Autor:
Ko-Chien Chen, Yonhong Liu, Chenchu Lin, Er-Yen (Nick) Yen, Francesca Citron, Xingdi Ma, Tan Lin, Philip Lorenzi, Florian Muller, Ronald DePinho
Publikováno v:
Cancer Research. 83:6053-6053
Sulfation of proteins, carbohydrates, lipids, and xenobiotics is an essential post-translational modification (PTM) process thought to play critical roles in diverse biological processes ranging from detoxification, cell signaling, and extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a7b2e95044b7790ee6a348b823d46c
https://doi.org/10.1158/1538-7445.am2023-6053
https://doi.org/10.1158/1538-7445.am2023-6053