Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Chen-lo H. Chen"'
Publikováno v:
European Journal of Immunology. 31:3798-3805
T cell antigen receptors (TCR) are composed of an antigen-recognizing unit, the TCRα β heterodimer, and a signal transduction ensemble, the CD3 complex. Whereas mammals possess three CD3 dimers (δ ϵ , γ ϵ , and ζ 2), birds and amphibians have
Autor:
Toshihito Tachibana, Takashi Iwase, Jiri Mestecky, Tomihisa Takahashi, Itaru Moro, Kazuo Komiyama, Kunihiko Kobayashi, Chen-lo H. Chen
Publikováno v:
Immunogenetics. 51:85-91
The J chain is a component of polymeric immunoglobulin (Ig) molecules and may play an important role in their polymerization and the transport of polymeric Ig across epithelial cells. In this study, the primary structure of the chicken J chain was de
Autor:
Takayuki Kubota, Jin-yi Wang, Thomas W. F. Göbel, Richard D. Hockett, Max D. Cooper, Chen-lo H. Chen
Publikováno v:
The Journal of Immunology. 163:3858-3866
Mammalian TCRδ genes are located in the midst of the TCRα gene locus. In the chicken, one large Vδ gene family, two Dδ gene segments, two Jδ gene segments, and one Cδ gene have been identified. The TCRδ genes were deleted on both alleles in α
Autor:
Olli Vainio, A. Six, Max D. Cooper, D. Courtois, Beat A. Imhof, Chen-lo H. Chen, Jean-Pierre Dangy, Dominique Dunon
Publikováno v:
The Journal of Experimental Medicine
The embryonic thymus is colonized by the influx of hemopoietic progenitors in waves. To characterize the T cell progeny of the initial colonization waves, we used intravenous adoptive transfer of bone marrow progenitors into congenic embryos. The exp
Publikováno v:
European Journal of Immunology. 26:1743-1747
A candidate avian CD6 homolog is identified by the S3 monoclonal antibody. The S3 antigen exists in a phosphorylated glycoprotein form of 130 kDa and a nonphosphorylated form of 110 kDa. Removal of phosphate groups and N-linked carbohydrates indicate
Publikováno v:
European Journal of Immunology. 26:420-427
To examine the role of T cell subpopulations in an acute graft-versus-host (GVH) reaction, gamma delta T cells and alpha beta T cells expressing one of the two prototypic V beta families were negatively isolated from adult blood samples and injected
Publikováno v:
Poultry Science. 73:1012-1018
This review summarizes our current view of gamma delta and alpha beta T cell development in the chicken. In it we emphasize the functional interplay between the gamma delta and alpha beta T cell subpopulations.
Autor:
Jill M. Lahti, Takayuki Kubota, Max D. Cooper, Leroy E. Hood, Chen-lo H. Chen, Chia-Lam Kuo, Thomas W. Göbel, Ruedi Aebersold
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1094-1098
T-cell receptor (TCR) alpha-chain (TCR alpha) and beta-chain (TCR beta) genes are well characterized in mammals, while only TCR beta genes have been identified in other vertebrates. To identify avian TCR alpha genes, we used monoclonal anti-CD3 antib
Publikováno v:
European Journal of Immunology. 22:1429-1435
Thymocyte development was monitored in an embryonic thymus organ culture system to establish a model in the chicken in which the functional nature of the thymic microenvironment could be assessed. Thymus lobes were removed from 10-day-old embryos and