Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Chen-Yong Lin"'
Autor:
Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yu-Wen Lin, Hou-Ping Sytwo, Amy Cheng, Kacy Yang, Khee-Siang Chan, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin
Publikováno v:
Genes and Diseases, Vol 9, Iss 4, Pp 1049-1061 (2022)
The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase pro
Externí odkaz:
https://doaj.org/article/e4eab8bc5f414af7a6dc171ad9545a8a
Autor:
Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yee Hui Yeo, Yu-Wen Lin, Hou-Ping Sytwo, Huan-Cheng Liu, Yuan Xu, Bailing Jia, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 692-702 (2019)
Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matrip
Externí odkaz:
https://doaj.org/article/a937494a0c724849935378a0784bc458
Autor:
Chun-Che Tseng, Bailing Jia, Robert B Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228874 (2020)
Matriptase plays important roles in epithelial integrity and function, which depend on its sorting to the basolateral surface of cells, where matriptase zymogen is converted to an active enzyme in order to act on its substrates. After activation, mat
Externí odkaz:
https://doaj.org/article/9ce66888cada408da86f78e8f18fd79f
Autor:
Chih-Hsin Lai, Shun-Cheng Chang, Yen-Ju Chen, Yi-Jie J. Wang, Ying-Jun J. Lai, Hsiang-Hua D. Chang, Eric B. Berens, Michael D. Johnson, Jehng-Kang Wang, Chen-Yong Lin
Publikováno v:
Biology Open, Vol 5, Iss 10, Pp 1380-1387 (2016)
Matriptase and prostasin, acting as a tightly coupled proteolytic cascade, were reported to be required for epidermal barrier formation in mouse skin. Here we show that, in human skin, matriptase and prostasin are expressed with an inverse pattern ov
Externí odkaz:
https://doaj.org/article/106b713c95a04c82bc71625287e24b34
Autor:
Shiao-Pieng Lee, Chen-Yu Kao, Shun-Cheng Chang, Yi-Lin Chiu, Yen-Ju Chen, Ming-Hsing G Chen, Chun-Chia Chang, Yu-Wen Lin, Chien-Ping Chiang, Jehng-Kang Wang, Chen-Yong Lin, Michael D Johnson
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192632 (2018)
The membrane-bound serine proteases prostasin and matriptase and the Kunitz-type protease inhibitors HAI-1 and HAI-2 are all expressed in human skin and may form a tightly regulated proteolysis network, contributing to skin pathophysiology. Evidence
Externí odkaz:
https://doaj.org/article/cede3e158bb248739dcdf6e4a5800d7a
Autor:
Shiao-Pieng Lee, Chen-Yu Kao, Shun-Cheng Chang, Yi-Lin Chiu, Yen-Ju Chen, Ming-Hsing G Chen, Chun-Chia Chang, Yu-Wen Lin, Chien-Ping Chiang, Jehng-Kang Wang, Chen-Yong Lin, Michael D Johnson
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198569 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0192632.].
Externí odkaz:
https://doaj.org/article/bbdb3de09fa7480da01f00e00190249f
Autor:
Chun-Che Tseng, Bailing Jia, Robert Barndt, Yayun Gu, Chien-Yu Chen, I-Chu Tseng, Sheng-Fang Su, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183507 (2017)
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase sheddin
Externí odkaz:
https://doaj.org/article/531b5c2837ea4b7fa0635edc7f63077b
Autor:
Frank Shiao, Li-Ching O Liu, Nanxi Huang, Ying-Jung J Lai, Robert J Barndt, Chun-Che Tseng, Jehng-Kang Wang, Bailing Jia, Michael D Johnson, Chen-Yong Lin
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170944 (2017)
Mutations of hepatocyte growth factor activator inhibitor (HAI)-2 in humans cause sodium loss in the gastrointestinal (GI) tract in patients with syndromic congenital sodium diarrhea (SCSD). Aberrant regulation of HAI-2 target protease(s) was propose
Externí odkaz:
https://doaj.org/article/bda3179e2def4e39af01ef62acb3ce4b
Autor:
Hui Chen Su, Yan A Liang, Ying-Jung J Lai, Yi-Lin Chiu, Robert B Barndt, Frank Shiao, Hsiang-Hua D Chang, Dajun D Lu, Nanxi Huang, Chun-Che Tseng, Jehng-Kang Wang, Ming-Shyue Lee, Michael D Johnson, Shih-Ming Huang, Chen-Yong Lin
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167894 (2016)
The membrane-associated serine proteases matriptase and prostasin are believed to function in close partnership. Their zymogen activation has been reported to be tightly coupled, either as a matriptase-initiated proteolytic cascade or through a mutua
Externí odkaz:
https://doaj.org/article/85d8b41ddb7d4931b9117d765c2ddc0e
Autor:
Chih-Hsin Lai, Ying-Jung J Lai, Feng-Pai Chou, Hsiang-Hua D Chang, Chun-Che Tseng, Michael D Johnson, Jehng-Kang Wang, Chen-Yong Lin
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152904 (2016)
Significant proteolysis may occur during milk synthesis and secretion, as evidenced by the presence of protease-protease inhibitor complex containing the activated form of the type 2 transmembrane serine protease matriptase and the transmembrane Kuni
Externí odkaz:
https://doaj.org/article/b8c3f6d734a04379916e026fa4f59e80