Výsledky vyhledávání - "Chen-Hua Chuang"

Akademický článek

Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression

Autor: Philip Vitorino, Chen-Hua Chuang, Alexandre Iannello, Xi Zhao, Wade Anderson, Ronald Ferrando, Zhaomei Zhang, Shravanthi Madhavan, Holger Karsunky, Laura R. Saunders

Publikováno v: Translational Oncology, Vol 14, Iss 1, Pp 100883- (2021)

Rovalpituzumab tesirine (Rova-T) offers a targeted therapy for ~85% of SCLC patients whose tumors express DLL3, but clinical dosing is limited due to off-target toxicities. We hypothesized that a sub-efficacious dose of Rova-T combined with anti-PD1,

Externí odkaz: https://doaj.org/article/117d11cd0102492081c6552a745ddb18

Zobrazit plný text záznamu

Akademický článek

Axon-like protrusions promote small cell lung cancer migration and metastasis

Autor: Dian Yang, Fangfei Qu, Hongchen Cai, Chen-Hua Chuang, Jing Shan Lim, Nadine Jahchan, Barbara M Grüner, Christin S Kuo, Christina Kong, Madeleine J Oudin, Monte M Winslow, Julien Sage

Publikováno v: eLife, Vol 8 (2019)

Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene p

Externí odkaz: https://doaj.org/article/fda050c064b3492b90714973d6d4255b

Zobrazit plný text záznamu

Akademický článek

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

KRAS-driven cancers remain refractory to current clinical therapies. In this study, the authors show that lung and pancreatic cancers expressing oncogenic KRAS can be targeted by genetic inhibition of FOSL1, which involves downregulation of genes of

Externí odkaz: https://doaj.org/article/b67e9794d6104499b87c9422aa01ff4a

Zobrazit plný text záznamu

Akademický článek

A Conditional System to Specifically Link Disruption of Protein-Coding Function with Reporter Expression in Mice

Autor: Shin-Heng Chiou, Caroline Kim-Kiselak, Viviana I. Risca, Megan K. Heimann, Chen-Hua Chuang, Aurora A. Burds, William J. Greenleaf, Tyler E. Jacks, David M. Feldser, Monte M. Winslow

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 2078-2086 (2014)

Conditional gene deletion in mice has contributed immensely to our understanding of many biological and biomedical processes. Despite an increasing awareness of nonprotein-coding functional elements within protein-coding transcripts, current gene-tar

Externí odkaz: https://doaj.org/article/e7a176c69bed42c0b44d3b2a6e4e8285

Zobrazit plný text záznamu

Akademický článek

Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.

Autor: Chen-Hua Chuang, Marsha D Wallace, Christian Abratte, Teresa Southard, John C Schimenti

Publikováno v: PLoS Genetics, Vol 6, Iss 9, p e1001110 (2010)

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation

Externí odkaz: https://doaj.org/article/c509e80d8f10423e911350166c8b30e2

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání