Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chen-Hong Ding"'
Autor:
Yu Peng, Hui Qian, Wen-Ping Xu, Meng-Chao Xiao, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Xin Zhang, Wei-Fen Xie
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-13 (2024)
Abstract Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nuclear factor 1α (HNF1α) is a k
Externí odkaz:
https://doaj.org/article/0cc36a7632b24a7992e75b72c84f5b0f
Autor:
Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YAP are not fully understood. In t
Externí odkaz:
https://doaj.org/article/cc95ff42b3c84cd6a0cf53496f64f164
Autor:
Jin-Pei Liu, Shao-Hua Song, Pei-Mei Shi, Xiao-Yu Qin, Bai-Nan Zheng, Shu-Qing Liu, Chen-Hong Ding, Xin Zhang, Wei-Fen Xie, Yi-Hai Shi, Wen-Ping Xu
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The activation of hepatic stellate cells (HSCs) has been emphasized as a leading event of the pathogenesis of liver cirrhosis, while the exact mechanism of its activation is largely unknown. Furthermore, the novel non-invasive pre
Externí odkaz:
https://doaj.org/article/ff72559c1cd246488e6baa05f469f0b8
Autor:
Yuan-Yuan Luo, Ke-Gong Tao, Yi-Ting Lu, Bin-Bin Li, Kai-Ming Wu, Chen-Hong Ding, Fang-Zhi Yan, Yue Liu, Yong Lin, Xin Zhang, Xin Zeng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, and its incidence is still high in China. This study aimed to investigate the circular RNAs (circRNAs) involved in the development of HCC and elucidate the mechanis
Externí odkaz:
https://doaj.org/article/c714f7a2382441c29023a9af6a1016c5
Autor:
Chen-Hong Ding, Chuan Yin, Shi-Jie Chen, Liang-Zhi Wen, Kai Ding, Shu-Juan Lei, Jin-Pei Liu, Jian Wang, Kai-xian Chen, Hua-liang Jiang, Xin Zhang, Cheng Luo, Wei-Fen Xie
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-14 (2018)
Abstract Background Our previous study has demonstrated that hepatocyte nuclear factor 1α (HNF1α) exerts potent therapeutic effects on hepatocellular carcinoma (HCC). However, the molecular mechanisms by which HNF1α reverses HCC malignancy need to
Externí odkaz:
https://doaj.org/article/fb9a88e56d2a4b44a8ad56f9a473942e
Autor:
Wei-Fen Xie, Xin Zhang, Cheng Luo, Bing Zhou, Ya-Xi Yang, Feng Yang, Shu-Qing Liu, Xin-Yan Zhu, Bai-Nan Zheng, Chen-Hong Ding, Qin-Juan Sun, Sen-Hao Xiao, Shi-Jie Chen, Ling-Yan Cai
Supplementary Table S3. Pathway analysis of differentially expressed genes in RNA-seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2942782b2ec3faa87be871dfba2d42
https://doi.org/10.1158/0008-5472.22427601.v1
https://doi.org/10.1158/0008-5472.22427601.v1
Autor:
Wei-Fen Xie, Xin Zhang, Cheng Luo, Bing Zhou, Ya-Xi Yang, Feng Yang, Shu-Qing Liu, Xin-Yan Zhu, Bai-Nan Zheng, Chen-Hong Ding, Qin-Juan Sun, Sen-Hao Xiao, Shi-Jie Chen, Ling-Yan Cai
Supplementary Figure S1. p300 is a potential target in HCC. Supplementary Figure S2. B029-2 is a potential and selective catalytic p300/CBP inhibitor that targets HCC.Supplementary Figure S3. Targeting p300 suppresses the cell-proliferation of HCC ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e653b27489bf00bf65120ce4f202b9
https://doi.org/10.1158/0008-5472.22427613.v1
https://doi.org/10.1158/0008-5472.22427613.v1
Autor:
Wei-Fen Xie, Xin Zhang, Cheng Luo, Bing Zhou, Ya-Xi Yang, Feng Yang, Shu-Qing Liu, Xin-Yan Zhu, Bai-Nan Zheng, Chen-Hong Ding, Qin-Juan Sun, Sen-Hao Xiao, Shi-Jie Chen, Ling-Yan Cai
Targeting epigenetics in cancer has emerged as a promising anticancer strategy. p300/CBP is a central regulator of epigenetics and plays an important role in hepatocellular carcinoma (HCC) progression. Tumor-associated metabolic alterations contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4089fc03e9da46a37584289439bffab1
https://doi.org/10.1158/0008-5472.c.6512751.v1
https://doi.org/10.1158/0008-5472.c.6512751.v1
Autor:
Fang‐Zhi Yan, Hui Qian, Fang Liu, Chen‐Hong Ding, Shu‐Qing Liu, Meng‐Chao Xiao, Shi‐Jie Chen, Xin Zhang, Cheng Luo, Wei‐Fen Xie
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(9)
Protein arginine methyltransferase 1 (PRMT1) has been reported to be involved in various diseases. The expression of PRMT1 was increased in cirrhotic livers from human patients. However, the role of PRMT1 in hepatic fibrogenesis remains largely unexp
Autor:
Chang-Peng Zhu, Chen-Kai Huang, Ya-Lu Cui, Weiping Zhou, Jin Ding, Chen-Hong Ding, Ji-Feng Feng, Yuan Yang, Xin Zhang, Wen-Ping Xu, Wei-Fen Xie, Bin Lu, Jin-Pei Liu
Publikováno v:
Gut. 69:1309-1321
ObjectiveAutophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated the feasibility of sensitising HCC cells to sorafenib by modulating miR-541-initiated microRNA-autophag