Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Chen-Chun Pai"'
Autor:
Aden Chun Hei Kwok, Amy Downing, Paul Affleck, Hannah Rossington, Matt Howard-Murray, Julliet Lwiindi, Chen-Chun Pai, Catriona Gilmour Hamilton
Publikováno v:
International Journal of Population Data Science, Vol 9, Iss 5 (2024)
Objective and Approach In 2017, the charity Cancer Research UK funded a UK Colorectal Cancer Intelligence Hub to create the COloRECTal cancer data Repository (CORECT-R). This was intended to be a single research data system that links all datasets ac
Externí odkaz:
https://doaj.org/article/da186e0362044a98ba031b33064962fc
Autor:
Chen-Chun Pai, Ellen Heitzer, Sibyl Bertrand, Sophia Toumazou, Timothy C Humphrey, Stephen E Kearsey
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0271016 (2023)
We constructed a panel of S. pombe strains expressing DNA polymerase ε variants associated with cancer, specifically POLES297F, POLEV411L, POLEL424V, POLES459F, and used these to compare mutation rates determined by canavanine resistance with other
Externí odkaz:
https://doaj.org/article/f89f9d8a1a444085aa8fa8459f3bf0c3
Autor:
Ignacio Soriano, Enrique Vazquez, Nagore De Leon, Sibyl Bertrand, Ellen Heitzer, Sophia Toumazou, Zhihan Bo, Claire Palles, Chen-Chun Pai, Timothy C Humphrey, Ian Tomlinson, Sue Cotterill, Stephen E Kearsey
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associa
Externí odkaz:
https://doaj.org/article/41959734e90f44aea3b54eb5d11908ec
Autor:
Chen-Chun Pai, Samuel C Durley, Wei-Chen Cheng, Nien-Yi Chiang, Jennifer Peters, Torben Kasparek, Elizabeth Blaikley, Boon-Yu Wee, Carol Walker, Stephen E Kearsey, Francesca Buffa, Johanne M Murray, Timothy C Humphrey
Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430e423c224ed90a7ebfeba2d915668a
https://doi.org/10.1093/nar/gkad160
https://doi.org/10.1093/nar/gkad160
Autor:
Chen-Chun Pai, Anastasiya Kishkevich, Rachel S. Deegan, Andrea Keszthelyi, Lisa Folkes, Stephen E. Kearsey, Nagore De León, Ignacio Soriano, Robertus Antonius Maria de Bruin, Antony M. Carr, Timothy C. Humphrey
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2693-2705 (2017)
Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the tran
Externí odkaz:
https://doaj.org/article/476647b5f2124f98a48b881cec80a1fc
Publikováno v:
IEEE Transactions on Circuits and Systems II: Express Briefs. 67:1614-1618
This brief presents an energy-efficient elliptic curve cryptography (ECC) processor for Internet of Things (IoT) security applications. The proposed processor supports dual-field computations, and employs various design techniques across the algorith
Autor:
Lydia Hulme, John Prudden, Carol Walker, Timothy C. Humphrey, Samuel C. Durley, Adam T. Watson, Helen Tinline-Purvis, Boon-Yu Wee, Johanne M. Murray, Anoushka Davé, Chen-Chun Pai, Jason K Cullen, Antony M. Carr, Sovan Sarkar
Publikováno v:
Nucleic Acids Research
The healing of broken chromosomes by de novo telomere addition, while a normal developmental process in some organisms, has the potential to cause extensive loss of heterozygosity, genetic disease, or cell death. However, it is unclear how de novo te
Autor:
Claire Palles, Sue Cotterill, Sophia Toumazou, Ignacio Soriano, Stephen E. Kearsey, Ian Tomlinson, Sibyl Bertrand, Enrique Vázquez, Zhihan Bo, Nagore De León, Chen-Chun Pai, Ellen Heitzer, Timothy C. Humphrey
Publikováno v:
Soriano, I, Vazquez, E, De Leon, N, Bertrand, S, Heitzer, E, Toumazou, S, Bo, Z, Palles, C, Pai, C, Humphrey, T C, Tomlinson, I, Cotterill, S, Kearsey, S E & Nitiss, J L (ed.) 2021, ' Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication ', PLoS Genetics, vol. 17, no. 7, pp. e1009526 . https://doi.org/10.1371/journal.pgen.1009526
PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
PLoS Genetics
Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736292b02ba16dfe494bf8ee2923a22
https://openaccess.sgul.ac.uk/id/eprint/113593/1/journal.pgen.1009526.pdf
https://openaccess.sgul.ac.uk/id/eprint/113593/1/journal.pgen.1009526.pdf
Autor:
Chen‐Chun Pai, Stephen E. Kearsey
Publikováno v:
Genes, Vol 8, Iss 2, p 57 (2017)
A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities,
Externí odkaz:
https://doaj.org/article/dc44b3c3e3da43eab960e5f7eb8dc5f5
Autor:
Timothy C. Humphrey, Nien-Yi Chiang, Francesca M. Buffa, Johanne M. Murray, Wei-Chen Cheng, Chen-Chun Pai, Samuel C. Durley, Carol Walker, Boon-Yu Wee, Stephen E. Kearsey
Persistent DNA damage arising from unrepaired broken chromosomes or telomere loss can promote DNA damage checkpoint adaptation, and cell cycle progression, thereby increasing cell survival but also genome instability. However, the nature and extent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8481901c73f7ccb8316ac6de342c2ce4
https://doi.org/10.1101/2020.08.26.268565
https://doi.org/10.1101/2020.08.26.268565