Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Chen-Chen Kan"'
Publikováno v:
Letters in Drug Design & Discovery. 2:364-371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47aac718b2e1849859821aa79bca4f01
https://doi.org/10.2174/1570180054405811
https://doi.org/10.2174/1570180054405811
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:2437-2447
Novel human immunodeficiency virus (HIV) protease inhibitors are urgently needed for combating the drug-resistance problem in the fight against AIDS. To facilitate lead discovery of HIV protease inhibitors, we have developed a safe, convenient, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290c50f02214ac5ab6d77e281a1b883c
https://doi.org/10.1128/aac.48.7.2437-2447.2004
https://doi.org/10.1128/aac.48.7.2437-2447.2004
Publikováno v:
European Journal of Biochemistry. 269:3697-3704
Tyrosyl-DNA phosphodiesterase (TDP) cleaves the phosphodiester bond linking the active site tyrosine residue of topoisomerase I with the 3′ terminus of DNA in topoisomerase I–DNA complexes which accumulate during treatment of cancer with camptoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64bd454021742073c31cdefd717e0eac
https://doi.org/10.1046/j.1432-1033.2002.03059.x
https://doi.org/10.1046/j.1432-1033.2002.03059.x
Autor:
Yali Deng, Patrick M O'Connor, Chen-Chen Kan, Pamela Myers, James Register, Luo Chun, Stephen Margosiak, Binh Nguyen, Kevin Ryan, Ping Chen, Karen Lundgren, Anna Tempczyk-Russell
Publikováno v:
Cell. 100(6):681-692
The checkpoint kinase Chk1 is an important mediator of cell cycle arrest following DNA damage. The 1.7 Å resolution crystal structures of the human Chk1 kinase domain and its binary complex with an ATP analog has revealed an identical open kinase co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136b6d82cbd6cf6c7029548f3da66a8
Autor:
Michele Ann Mctigue, Michael R Gehring, Chris Pinko, J. Ernest Villafranca, Chen-Chen Kan, Camran V Parast, Krzysztof Appelt, Richard E. Showalter, Barbara Mroczkowski, John A Wickersham, Anna Tempczyk-Russell
Publikováno v:
Structure. 7:319-330
Background: Angiogenesis is involved in tumor growth, macular degeneration, retinopathy and other diseases. Vascular endothelial growth factor (VEGF) stimulates angiogenesis by binding to specific receptors (VEGFRs) on the surface of vascular endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd0c114d6524dab68f410cf59cf22b
https://doi.org/10.1016/s0969-2126(99)80042-2
https://doi.org/10.1016/s0969-2126(99)80042-2
Publikováno v:
bchm. 379:185-192
Human pro-matrix metalloproteinase 3 (proMMP-3) lacking the N-terminal 34 amino acids and the C-terminal hemopexin-like domain was expressed in E. coli and used to investigate the process of proenzyme activation and its interaction with an endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aacf20d3a95914e7bad543dbc902b31
https://doi.org/10.1515/bchm.1998.379.2.185
https://doi.org/10.1515/bchm.1998.379.2.185
Autor:
Tom K Huffaker, Leora S. Zalman, Susan L. Binford, Amy K. Patick, Christopher Pinko, Chen-Chen Kan
Publikováno v:
Antiviral Research. 33:215-218
The nucleotide sequence of the human cytomegalovirus (HCMV) protease gene from two laboratory strains and seven clinical isolates, both ganciclovir-sensitive and -resistant, was examined to determine the genetic variability of the HCMV protease catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb3dd4ad0bb09e89c95dfc918e3cadc
https://doi.org/10.1016/s0166-3542(96)01016-9
https://doi.org/10.1016/s0166-3542(96)01016-9
Publikováno v:
Journal of Biological Chemistry. 270:22507-22513
Soluble recombinant human fibroblast collagenase catalytic domain was highly expressed and purified from Escherichia coli. The expression construct utilized the T7 gene 10 promoter for transcription of a two-cistron messenger RNA which encoded the ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860aba942711fcd32d5c72f0bd1bd1a1
https://doi.org/10.1074/jbc.270.38.22507
https://doi.org/10.1074/jbc.270.38.22507
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6114-6118
The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafd1aee3d4412d55b91cfa159b35da8
https://doi.org/10.1073/pnas.89.13.6114
https://doi.org/10.1073/pnas.89.13.6114
Publikováno v:
Molecular Analysis and Genome Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb44ec630dc79910935e83d052e81a8
https://doi.org/10.1002/0470020202.ch14
https://doi.org/10.1002/0470020202.ch14
