Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Chen Yuan Kao"'
Autor:
Samik Das, Jenna C. Harris, Erica J. Winter, Chen‐Yuan Kao, Emily S. Day, Eleftherios Terry Papoutsakis
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Hematopoietic stem and progenitor cells (HSPCs) are desirable targets for gene therapy but are notoriously difficult to target and transfect. Existing viral vector‐based delivery methods are not effective in HSPCs due to their cytotoxicity
Externí odkaz:
https://doaj.org/article/aca1d621ab66431490d1c4b03729a9b3
Publikováno v:
Biology, Vol 12, Iss 5, p 677 (2023)
Cytokines and other growth factors are essential for cell expansion, health, function, and immune stimulation. Stem cells have the additional reliance on these factors to direct differentiation to the appropriate terminal cell type. Successful manufa
Externí odkaz:
https://doaj.org/article/b7e6ce75ae024d1392f6b26f7e1cf948
Autor:
null Samik Das, null Jenna C. Harris, null Erica J. Winter, null Chen‐Yuan Kao, null Emily S. Day, null Eleftherios Terry Papoutsakis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388dd6a8aa98247261280f036c111a6e
https://doi.org/10.1002/btm2.10456/v2/response1
https://doi.org/10.1002/btm2.10456/v2/response1
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203991 (2018)
Megakaryocytes (Mks) derive from hematopoietic stem and progenitor cells (HSPCs) in the bone marrow and develop into large, polyploid cells that eventually give rise to platelets. As Mks mature, they migrate from the bone marrow niche into the vascul
Externí odkaz:
https://doaj.org/article/907f452e87ad4c728296aa8d86ef445e
Publikováno v:
Blood Advances. 4:804-814
Platelet transfusions are used to treat idiopathic or drug-induced thrombocytopenia. Platelets are an expensive product in limited supply, with limited storage and distribution capabilities because they cannot be frozen. We have demonstrated that, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68caa9165de6e5dc37c92f57b3c5baa5
https://doi.org/10.1182/bloodadvances.2019000753
https://doi.org/10.1182/bloodadvances.2019000753
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5355
Megakaryocytes release submicron size microparticles (MkMPs) in circulation. We have shown that MkMPs target CD34+ hematopoietic stem/progenitor cells (HSPCs) to induce megakaryocytic differentiation, and that small RNAs in MkMPs play an important ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d45244403f0f88ad971dfe625716b8
https://doi.org/10.3390/ijms23105355
https://doi.org/10.3390/ijms23105355
Publikováno v:
Journal of Controlled Release. 247:1-18
Megakaryocytic microparticles (MkMPs), the most abundant MPs in circulation, can induce the differentiation of hematopoietic stem and progenitor cells (HSPCs) into functional megakaryocytes. This MkMP capability could be explored for applications in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1facae75ecea4ba0470d2ba1e447d8e
https://doi.org/10.1016/j.jconrel.2016.12.021
https://doi.org/10.1016/j.jconrel.2016.12.021
Publikováno v:
Current opinion in biotechnology. 60
Extracellular vesicles (EVs) are membrane vesicles, the submicron-size microparticles and the nanometer-size exosomes, that carry RNAs, proteins and lipids from their parent cells. EV generation takes place under cellular activation or stress. Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6e30eb09d25f4a2928b5c7fcfff07e
https://pubmed.ncbi.nlm.nih.gov/30851486
https://pubmed.ncbi.nlm.nih.gov/30851486
Publikováno v:
Science Advances
Cell-derived microparticles, with their native recognition abilities, can be used as novel carriers for targeted cargo delivery to stem cells.
Hematopoietic stem and progenitor cells (HSPCs) are important target cells for gene therapy applicatio
Hematopoietic stem and progenitor cells (HSPCs) are important target cells for gene therapy applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90f243ffaaf8f9424423d2cfe39ed4e
https://pubmed.ncbi.nlm.nih.gov/30417099
https://pubmed.ncbi.nlm.nih.gov/30417099
Publikováno v:
2018 7th International Symposium on Next Generation Electronics (ISNE).
In this study, the "Intermittence Process" and "Inserted nano Ag particles process" are designed to deposit Gallium-doped ZnO (GZO) thin film and apply on pulse sensor. 300nm GZO thin films had been deposited on a flexible (PC) substrate by radio fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd4b2df0be54dfa310008d86f2988797
https://doi.org/10.1109/isne.2018.8394687
https://doi.org/10.1109/isne.2018.8394687