Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chen Lior"'
Autor:
Chen Lior, Debra Barki, Coral Halperin, Christine A. Iacobuzio-Donahue, David Kelsen, Ruth Scherz- Shouval
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114236- (2024)
Summary: The tumor microenvironment (TME) presents cells with challenges such as variable pH, hypoxia, and free radicals, triggering stress responses that affect cancer progression. In this study, we examine the stress response landscape in four carc
Externí odkaz:
https://doaj.org/article/5e248eed13fe46dfbb76bea7ab0852c5
Autor:
Shimrit Mayer, Tomer Milo, Achinoam Isaacson, Coral Halperin, Shoval Miyara, Yaniv Stein, Chen Lior, Meirav Pevsner-Fischer, Eldad Tzahor, Avi Mayo, Uri Alon, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we
Externí odkaz:
https://doaj.org/article/02b3d0850720428989cf063f0ad2829d
Autor:
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E. Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R. Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A. Porco, Christine A. Iacobuzio-Donahue, Nikolaus Schultz, David A. Tuveson, David Lyden, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Cancer-associated fibroblasts are transcriptionally rewired by signals from the cancer cells, resulting in heterogeneous populations. Here the authors show that loss of BRCA function in pancreatic cancer cells leads to HSF1–dependent accumulation o
Externí odkaz:
https://doaj.org/article/ace9d26882394fbe81d1eae2056e5de9
Autor:
Lee Shaashua, Shimrit Mayer, Chen Lior, Hagar Lavon, Alexander Novoselsky, Ruth Scherz-Shouval
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The circadian clock regulates diverse physiological processes by maintaining a 24-h gene expression pattern. Genetic and environmental cues that disrupt normal clock rhythms can lead to cancer, yet the extent to which this effect is controlled by the
Externí odkaz:
https://doaj.org/article/02e1d20eb2b240c0af25cf9b8f847cca
Publikováno v:
PLoS ONE; 8/9/2023, Vol. 18 Issue 8, p1-11, 11p
Autor:
Chen Lior, Veena Prahlad, Stuart K. Calderwood, Evandro A. De-Souza, Dimitra Bourboulia, Maurizio Zanetti, Rebecca C. Taylor, Patricija van Oosten-Hawle, Mark R. Wilson, D. Allan Drummond, Francesca Hodge, Lea Sistonen, Ruth Scherz-Shouval, R. Luke Wiseman, Richard I. Morimoto, Adrienne L. Edkins, Oded Rechavi, Della C. David
Publikováno v:
FASEB J
The FASEB journal 35(6), e21631 (2021). doi:10.1096/fj.202100566
2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, online, 2021-02-03-2021-02-04
The FASEB journal 35(6), e21631 (2021). doi:10.1096/fj.202100566
2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, online, 2021-02-03-2021-02-04
Autor:
Chen Lior, Lee Shaashua, Alexander Novoselsky, Ruth Scherz-Shouval, Shimrit Mayer, Hagar Lavon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
The circadian clock regulates diverse physiological processes by maintaining a 24-h gene expression pattern. Genetic and environmental cues that disrupt normal clock rhythms can lead to cancer, yet the extent to which this effect is controlled by the
Autor:
Shimrit Mayer, Hagar Lavon, Lee Shaashua, Chen Lior, Ruth Scherz-Shouval, Alexander Novoselsky
Publikováno v:
Cancer Research. 81:LB244-LB244
The tumor microenvironment (TME) comprised of multiple proteins, extracellular matrix(ECM) and various cell types that together promote tumor initiation, progression andhomeostasis in a cell-cell communication manner. In this study, we set to underst