Solid stress impairs lymphocyte infiltration into lymph-node metastases.

Autor: Jones D; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. djones1@bu.edu.; Harvard Medical School, Boston, MA, USA. djones1@bu.edu.; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA. djones1@bu.edu., Wang Z; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA., Chen IX; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Zhang S; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Banerji R; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Lei PJ; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Zhou H; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Xiao V; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA., Kwong C; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA., van Wijnbergen JWM; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pereira ER; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vakoc BJ; Harvard Medical School, Boston, MA, USA.; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA., Huang P; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nia HT; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Padera TP; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. tpadera@steele.mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. tpadera@steele.mgh.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2021 Dec; Vol. 5 (12), pp. 1426-1436. Date of Electronic Publication: 2021 Jul 19.

Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis.

Autor: Ferraro GB; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Luengo A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Kodack DP; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Deik A; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Bezwada D; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Blanc L; The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA.; Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France., Prideaux B; The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA.; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA., Jin X; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Posada JM; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Chen J; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chin CR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Amoozgar Z; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ferreira R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Chen IX; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Naxerova K; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ng C; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Westermark AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Duquette M; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Roberge S; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lindeman NI; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Lyssiotis CA; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; University of Michigan, Ann Arbor, MI, USA., Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Housman DE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Duda DG; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Brachtel E; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Golub TR; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Cantley LC; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA., Asara JM; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Davidson SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Lewis Sigler Institute, Princeton University, Princeton, NJ, USA., Fukumura D; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Dartois VA; The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA.; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Clish CB; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Jain RK; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. jain@steele.mgh.harvard.edu., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. mvh@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. mvh@mit.edu.

Publikováno v: Nature cancer [Nat Cancer] 2021 Nov; Vol. 2 (11), pp. 1243.

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.

Autor: Li W; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA.; Guangdong Laboratory Animal Monitoring Institute, Guangzhou, 510663, People's Republic of China., Li S; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA.; Department of Spinal Surgery, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, People's Republic of China., Chen IX; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Liu Y; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Ramjiawan RR; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Leung CH; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA.; Division of Urology, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong., Gerweck LE; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Fukumura D; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Loeffler JS; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Jain RK; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Duda DG; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA., Huang P; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA, 02114, USA. peigen@steele.mgh.harvard.edu.

Publikováno v: Radiation oncology (London, England) [Radiat Oncol] 2021 Mar 04; Vol. 16 (1), pp. 48. Date of Electronic Publication: 2021 Mar 04.

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.

Autor: Shigeta K; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Matsui A; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Kikuchi H; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Klein S; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Institute of Pathology, University Hospital Cologne, Cologne, Germany., Mamessier E; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Chen IX; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Aoki S; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Kitahara S; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Inoue K; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Shigeta A; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Hato T; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Ramjiawan RR; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Staiculescu D; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Zopf D; Drug Discovery, Bayer Pharma AG, Berlin, Germany., Fiebig L; Drug Discovery, Bayer Pharma AG, Berlin, Germany., Hobbs GS; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Quaas A; Institute of Pathology, University Hospital Cologne, Cologne, Germany., Dima S; Center for General Surgery and Liver Transplantation, Clinical Institute Fundeni, Bucharest, Romania., Popescu I; Center for General Surgery and Liver Transplantation, Clinical Institute Fundeni, Bucharest, Romania., Huang P; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Munn LL; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Cobbold M; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Goyal L; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Zhu AX; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Jain RK; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA., Duda DG; Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA duda@steele.mgh.harvard.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Nov; Vol. 8 (2).

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Autor: Saif M; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Kwanten WJ; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Laboratory of Experimental Medicine and Pediatrics (LEMP)-Gastroenterology and Hepatology, University of Antwerp, Wilrijk, Belgium., Carr JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Chen IX; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Posada JM; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Srivastava A; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Zhang J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Zheng Y; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Pinter M; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Chatterjee S; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Softic S; Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Kentucky College of Medicine and Kentucky Children's Hospital, Lexington, KY, USA., Kahn CR; Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., van Leyen K; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Bruns OT; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany., Jain RK; Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. jain@steele.mgh.harvard.edu., Bawendi MG; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. mgb@mit.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2020 Aug; Vol. 4 (8), pp. 801-813. Date of Electronic Publication: 2020 Jun 22.