KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Autor: Kauwe, Grant, Pareja-Navarro, Kristeen A., Yao, Lei, Chen, Jackson H., Wong, Ivy, Saloner, Rowan, Cifuentes, Helen, Nana, Alissa L., Shah, Samah, Li, Yaqiao, Le, David, Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Kramer, Joel H., Sacktor, Todd C., Schilling, Birgit, Gan, Li, Casaletto, Kaitlin B., Tracy, Tara E.

Publikováno v: bioRxiv

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we define a mechanism for plasticity repair in vulnerable neurons u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f64df8f8c76513cf7e306670bbd7e4c
https://europepmc.org/articles/PMC10312627/

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.

Autor: Kauwe G; Buck Institute for Research on Aging, Novato, CA USA., Pareja-Navarro KA; Buck Institute for Research on Aging, Novato, CA USA., Yao L; Buck Institute for Research on Aging, Novato, CA USA., Chen JH; Buck Institute for Research on Aging, Novato, CA USA., Wong I; Buck Institute for Research on Aging, Novato, CA USA., Saloner R; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA., Cifuentes H; Buck Institute for Research on Aging, Novato, CA USA., Nana AL; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA., Shah S; Buck Institute for Research on Aging, Novato, CA USA., Li Y; Gladstone Institutes, San Francisco, CA USA., Le D; Gladstone Institutes, San Francisco, CA USA., Spina S; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA., Grinberg LT; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA.; Weill Institute for Neurosciences, Department of Pathology, University of California, San Francisco USA., Seeley WW; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA.; Weill Institute for Neurosciences, Department of Pathology, University of California, San Francisco USA., Kramer JH; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA., Sacktor TC; The Robert F. Furchgott Center of Neural and Behavioral Science, Departments of Physiology and Pharmacology, Anesthesiology, and Neurology, State University of New York Health Sciences University, Brooklyn, NY USA., Schilling B; Buck Institute for Research on Aging, Novato, CA USA., Gan L; Helen and Robert Appel Alzheimer Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY USA., Casaletto KB; Memory and Aging Center, Department of Neurology, University of California, San Francisco USA., Tracy TE; Buck Institute for Research on Aging, Novato, CA USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 12. Date of Electronic Publication: 2023 Jun 12.