Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes

Autor: Kannan, Suraj, Miyamoto, Matthew, Zhu, Renjun, Lynott, Michaela, Guo, Jason, Chen, Elaine Zhelan, Colas, Alexandre R., Lin, Brian Leei, Kwon, Chulan

Publikováno v: In Cell Reports 25 April 2023 42(4)

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A transcriptional enhancer regulates cardiac maturation.

Autor: Htet M; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Lei S; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Bajpayi S; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Gangrade H; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Arvanitis M; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Zoitou A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Murphy S; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Chen EZ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Koleini N; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Lin BL; Department of Cell Biology, Neurobiology, and Anatomy and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Kwon C; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Institute of Cell Engineering, Johns Hopkins University, Baltimore, MD, USA., Tampakakis E; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA. etampak1@jhmi.edu.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. etampak1@jhmi.edu.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA. etampak1@jhmi.edu.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Jun; Vol. 3 (6), pp. 666-684. Date of Electronic Publication: 2024 May 30.