Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chen, Eitan"'
Autor:
Johnathan Cooper-Knock, Sai Zhang, Kevin P. Kenna, Tobias Moll, John P. Franklin, Samantha Allen, Helia Ghahremani Nezhad, Alfredo Iacoangeli, Nancy Y. Yacovzada, Chen Eitan, Eran Hornstein, Eran Ehilak, Petra Celadova, Daniel Bose, Sali Farhan, Simon Fishilevich, Doron Lancet, Karen E. Morrison, Christopher E. Shaw, Ammar Al-Chalabi, Jan H. Veldink, Janine Kirby, Michael P. Snyder, Pamela J. Shaw, Ian Blair, Naomi Wray, Matthew Kiernan, Miguel Mitne Neto, Adriano Chio, Ruben Cauchi, Wim Robberecht, Philip van Damme, Phillippe Corcia, Phillipe Couratier, Orla Hardiman, Russel McLaughlin, Marc Gotkine, Vivan Drory, Nicola Ticozzi, Vincenzo Silani, Jan Veldink, Leonard van den Berg, Mamede de Carvalho, Jesus Mora Pardina, Monica Povedano, Peter Andersen, Markus Wber, Nazli Başak, Christopher Shaw, Pamela Shaw, Karen Morrison, John Landers, Jonathan Glass
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108456- (2020)
Summary: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organize membrane lipid rafts (MLRs) important for cell signaling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vi
Externí odkaz:
https://doaj.org/article/7fac5ebf332545088de18b27ea1f88df
Autor:
William Sproviero, Yael Elbaz-Alon, Aleksey Shatunov, Chen Eitan, Philip Van Damme, Alfredo Iacoangeli, Ahmad Al Khleifat, CYNTHIA LOUIS, Chien-Hsiung Alan Yu, Johnathan Cooper-Knock, Ashley Jones
Publikováno v:
Nature Neuroscience. 25:433-445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f40490c52b477ffeaeb940977d3d7b1
https://doi.org/10.1038/s41593-022-01040-6
https://doi.org/10.1038/s41593-022-01040-6
Autor:
Sai Zhang, Johnathan Cooper-Knock, Annika K. Weimer, Minyi Shi, Tobias Moll, Jack N.G. Marshall, Calum Harvey, Helia Ghahremani Nezhad, John Franklin, Cleide dos Santos Souza, Ke Ning, Cheng Wang, Jingjing Li, Allison A. Dilliott, Sali Farhan, Eran Elhaik, Iris Pasniceanu, Matthew R. Livesey, Chen Eitan, Eran Hornstein, Kevin P. Kenna, Jan H. Veldink, Laura Ferraiuolo, Pamela J. Shaw, Michael P. Snyder, Ian Blair, Naomi R. Wray, Matthew Kiernan, Miguel Mitne Neto, Adriano Chio, Ruben Cauchi, Wim Robberecht, Philip van Damme, Philippe Corcia, Philippe Couratier, Orla Hardiman, Russell McLaughin, Marc Gotkine, Vivian Drory, Nicola Ticozzi, Vincenzo Silani, Leonard H. van den Berg, Mamede de Carvalho, Jesus S. Mora Pardina, Monica Povedano, Peter Andersen, Markus Weber, Nazli A. Başak, Ammar Al-Chalabi, Chris Shaw, Karen E. Morrison, John E. Landers, Jonathan D. Glass
Publikováno v:
Neuron. 110(6)
Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed a machine learning approach ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49d72f3068f1aa25ec812fc4c9fde83
https://pubmed.ncbi.nlm.nih.gov/35298913
https://pubmed.ncbi.nlm.nih.gov/35298913
Autor:
Matthieu Moisse, Daphna Rothschild, Kevin P. Kenna, Tsviya Olender, Eran Segal, Aleksey Shatunov, Elik Chapnik, Elad Barkan, Sebastian Werneburg, Alfredo Iacoangeli, Justin K. Ichida, Pamela J. Shaw, Ammar Al-Chalabi, Farhan Smk, Dorothy P. Schafer, Eran Hornstein, Omer Weissbrod, Nancy S Yacovzada, Ashley R. Jones, van Eijk Kr, William Sproviero, Van Damme P, van den Berg Lh, Jan H. Veldink, Hung S, Robert H. Brown, van der Spek Raa, Aviad Siany, Chen Eitan, Johnathan Cooper-Knock, Al Khleifat A, Hemali Phatnani
The non-coding genome is substantially larger than the protein-coding genome but is largely unexplored by genetic association studies. Here, we performed region-based burden analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7694d3e8d29fe3d56d03a5d31951adc3
https://doi.org/10.1101/2021.06.03.446863
https://doi.org/10.1101/2021.06.03.446863
Autor:
Eran Hornstein, Eran Yanowski, Revital Ravid, Alon Savidor, Gregor Rot, Chen Eitan, Natalia Rivkin, Aviad Siany, Gunter Meister, Yishai Levin, Hagai Marmor-Kollet
Argonaute 2 (AGO2), the effector protein partner of microRNAs (miRNAs) in the cytoplasmic RNA induced silencing complex, is further involved in nuclear RNA processing. However, a role for AGO2 in regulation of alternative polyadenylation was not yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183507682bc577f3119421d5ce001e91
https://doi.org/10.1101/2020.12.15.422806
https://doi.org/10.1101/2020.12.15.422806
Autor:
Pavel Ivanov, Natalia Rivkin, Nancy Kedersha, Tsviya Olender, Beata Toth Cohen, Tamar Geiger, Hagai Marmor-Kollet, Eran Hornstein, Aviad Siany, Thomas Moens, Nir Cohen, Naama Knafo, John Cooper Knock, Ludo Van Den Bosch, Chen Eitan, Paul A. Anderson, Yehuda M. Danino, Adrian Higginbottom
Summary Cytoplasmic stress granules (SG) form in response to a variety of cellular stresses by phase-separation of proteins associated with non-translating mRNAs. SG provide insight into the biology of neurodegeneration, including amyotrophic lateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78446d05656750c4db31a8498bb103d0
Autor:
Johnathan Cooper-Knock, Sai Zhang, Kevin P. Kenna, Tobias Moll, John Franklin, Samantha Allen, Helia Ghahremani Nezhad, Nancy S. Yacovzada, Chen Eitan, Eran Hornstein, Eran Ehilak, Petra Celadova, Daniel Bose, Sali MK Farhan, Simon Fishilevich, Doron Lancet, Karen E. Morrison, Chris Shaw, Ammar Al-Chalabi, Project MinE ALS Sequencing Consortium, Jan H. Veldink, Janine Kirby, Michael P. Snyder, Pamela J. Shaw
Publikováno v:
SSRN Electronic Journal.
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organise membrane lipid rafts (MLR) important for cell signalling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vivo. Genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdc3564d09bc9dd38060b51407b33cb
https://doi.org/10.2139/ssrn.3606796
https://doi.org/10.2139/ssrn.3606796
Autor:
Sai Zhang, Johnathan Cooper-Knock, Annika K. Weimer, Minyi Shi, Tobias Moll, Calum Harvey, Helia Ghahremani Nezhad, John Franklin, Cleide dos Santos Souza, Cheng Wang, Jingjing Li, Chen Eitan, Eran Hornstein, Kevin P. Kenna, Project MinE Sequencing Consortium, Jan H. Veldink, Laura Ferraiuolo, Pamela J. Shaw, Michael P. Snyder
Publikováno v:
SSRN Electronic Journal.
Amyotrophic lateral sclerosis (ALS) is a complex disease centered on progressive death of motor neurons. Despite heritability estimates of 52%, GWAS studies have discovered only seven genome-wide significant hits. We developed a new machine learning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b61cc0e22600324e32b51323a3ea61d
https://doi.org/10.2139/ssrn.3744427
https://doi.org/10.2139/ssrn.3744427
Autor:
Amitai D. Mandelbaum, Jesus S. Mora, Giancarlo Costaguta, Timothy M. Miller, Guy Haim, Revital Ravid, Ofer Yizhar, Cristiane de Araújo Martins Moreno, Irit Reichenstein, Tsviya Olender, Nicole M. Bode, Smita Saxena, Karen E. Morrison, Hemali Phatnani, Natali Rivkin, Orla Hardiman, Robert H. Brown, Matthew B. Harms, Kim A. Lennox, Kristel R. van Eijk, Jing Liang, Sandra Diaz-Garcia, A. Nazli Basak, Gilad Beck, Samuel L. Pfaff, John Ravits, Chen Eitan, Thomas Möller, Beáta Tóth, Jan H. Veldink, Eran Yanowski, Sali M.K. Farhan, Pamela J. Shaw, Ammar Al-Chalabi, Iddo Magen, Mark A. Behlke, Leonard H. van den Berg, John Landers, Rivka Levy, Elena Ainbinder, Jeffrey K. Rymer, Eran Hornstein, Christina Gross, Aviad Siany, Mariah L. Hoye
Publikováno v:
Sci Transl Med
Science Translational Medicine, 11(523). American Association for the Advancement of Science
Science Translational Medicine
Science Translational Medicine, 11(523). American Association for the Advancement of Science
Science Translational Medicine
Motor neuron–specific microRNA-218 (miR-218) has recently received attention because of its roles in mouse development. However, miR-218 relevance to human motor neuron disease was not yet explored. Here, we demonstrate by neuropathology that miR-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d030811dc749c7fe7014cc4299036f
https://pubmed.ncbi.nlm.nih.gov/31852800
https://pubmed.ncbi.nlm.nih.gov/31852800
CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles
Autor:
Nadine Graubardt, Chen Eitan, Tamara Berkutzki, Michal Schwartz, Anat London, Catarina Raposo, Merav Cohen
Publikováno v:
Journal of Neuroscience. 34:10141-10155
Monocyte-derived macrophages (mo-MΦs) and T cells have been shown to contribute to spinal cord repair. Recently, the remote brain choroid plexus epithelium (CP) was identified as a portal for monocyte recruitment, and its activation for leukocyte tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb990d695e2a2e565e8f5a21c40dc44
https://doi.org/10.1523/jneurosci.0076-14.2014
https://doi.org/10.1523/jneurosci.0076-14.2014