Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Autor: Chornokur, Ganna, Lin, Hui-Yi, Tyrer, Jonathan P., Lawrenson, Kate, Dennis, Joe, Amankwah, Ernest K., Qu, Xiaotao, Tsai, Ya-Yu, Jim, Heather S. L., Chen, Zhihua, Chen, Ann Y., Permuth-Wey, Jennifer, Aben, Katja KH., Ekici, Arif B., Phelan, Catherine M.

Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberra

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Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.

Autor: Lo, Amy C. Y., Chen, Ann Y. S., Hung, Victor K. L., Lai Ping Yaw, Fung, Maggie K. L., Ho, Maggie C. Y., Tsang, Margaret C. S., Chung, Stephen S. M., Chung, Sookja K.

Publikováno v: Journal of Cerebral Blood Flow & Metabolism; Aug2005, Vol. 25 Issue 8, p998-1011, 14p, 4 Color Photographs, 1 Diagram, 4 Charts, 5 Graphs

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Autor: Chornokur G; Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America., Lin HY; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America., Tyrer JP; Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Lawrenson K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America., Dennis J; Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Amankwah EK; Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America; Clinical and Translational Research Organization, All Children's Hospital Johns Hopkins Medicine, St Petersburg, Florida, United States of America., Qu X; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America., Tsai YY; Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America., Jim HS; Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, United States of America., Chen Z; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America., Chen AY; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America., Permuth-Wey J; Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America., Aben KK; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; Comprehensive Cancer Center The Netherlands, Nijmegen, The Netherlands., Anton-Culver H; Genetic Epidemiology Research Institute, Center for Cancer Genetics Research and Prevention, University of California Irvine, Irvine, California, United States of America., Antonenkova N; N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus., Bruinsma F; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Bandera EV; Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America., Bean YT; Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America., Beckmann MW; Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany., Bisogna M; Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America., Bjorge L; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway., Bogdanova N; Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany., Brinton LA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America., Brooks-Wilson A; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada., Bunker CH; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America., Butzow R; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland; Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland., Campbell IG; Cancer Genetics Laboratory Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia; Department of Pathology, the University of Melbourne, Parkville, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Carty K; Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom; The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Chang-Claude J; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Cook LS; Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America., Cramer DW; Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Dansonka-Mieszkowska A; Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., du Bois A; Department of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Despierre E; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Dicks E; Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Doherty JA; Department of Epidemiology, The Geisel School of Medicine Hanover, New Hampshire, United States of America; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dürst M; Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America., Eccles DM; Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Edwards RP; Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America., Ekici AB; Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany., Fasching PA; Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany; University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, United States of America., Fridley BL; Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Gao YT; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Gentry-Maharaj A; Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Glasspool R; The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Goodman MT; Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America., Gronwald J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Harrington P; Department of Oncology, The Centre for Cancer Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom., Harter P; Department of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. 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Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Lu K; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America., Lubinski J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lundvall L; The Juliane Marie Centre, Department of Gynecology, Righospitalet, University of Copenhagen, Copenhagen, Denmark., Massuger LF; Department of Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands., Matsuo K; Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan., McGuire V; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America., McLaughlin JR; Public Health Ontario, Toronto, Canada., McNeish I; Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer research Centre, Beatson Institute for Cancer Research, Glasgow, UK., Menon U; 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Publikováno v: PloS one [PLoS One] 2015 Jun 19; Vol. 10 (6), pp. e0128106. Date of Electronic Publication: 2015 Jun 19 (Print Publication: 2015).