Tumor-Microenvironment Characterization of the MB49 Non-Muscle-Invasive Bladder-Cancer Orthotopic Model towards New Therapeutic Strategies

Autor: Sonia Domingos-Pereira, Karthik Sathiyanadan, Lenka Polak, Jacques-Antoine Haefliger, Martina Schmittnaegel, Carola H. Ries, Patrice Jichlinski, Beat Roth, Laurent Derré, Denise Nardelli-Haefliger

Publikováno v: International journal of molecular sciences, vol. 24, no. 1, pp. 123
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 123

Bacillus Calmette-Guérin (BCG) instillations for the treatment of non-muscle-invasive bladder cancer patients can result in significant side effects and treatment failure. Immune checkpoint blockade and/or decreasing tumor-infiltrating myeloid suppr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9ba0b138ad54fda2d70397490726e9
https://serval.unil.ch/resource/serval:BIB_0026FCE56475.P001/REF.pdf

MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2

Autor: Tue W. Kragstrup, Anne Sofie Sørensen, Mads Brüner, Søren Lomholt, Morten A Nielsen, Peter Schafer, Bent Deleuran

Publikováno v: Kragstrup, T W, Sørensen, A S, Brüner, M, Lomholt, S, Nielsen, M A, Schafer, P & Deleuran, B 2022, ' MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2 ', International Immunopharmacology, vol. 112, 109267, pp. 109267 . https://doi.org/10.1016/j.intimp.2022.109267

Background: The development of novel treatment strategies of immune-mediated inflammatory arthritis (IMIA) is still a clinical unmet need. The mitogen-activated protein kinase (MAPK) pathway is activated by environmental stressors, growth factors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e54ab673193fa638c9316149fb2b88
https://pure.au.dk/portal/da/publications/mapk-activated-kinase-2-inhibition-shifts-the-chemokine-signature-in-arthritis-synovial-fluid-mononuclear-cells-from-cxcr3-to-cxcr2(e2c6ddf7-4075-4520-8be8-3cd04425cc32).html

Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production

Autor: Mariska Kerstholt, Freek R van de Schoor, Marije Oosting, Simone J C F M Moorlag, Yang Li, Martin Jaeger, Wouter A van der Heijden, Rahajeng N Tunjungputri, Jéssica C dos Santos, Brenda Kischkel, Hedwig D Vrijmoeth, M E Baarsma, Bart-Jan Kullberg, Mihaela Lupse, Joppe W Hovius, Cees C van den Wijngaard, Mihai G Netea, Quirijn de Mast, Leo A B Joosten

Publikováno v: Clinical and Experimental Immunology, 210, 53-67
Clinical and Experimental Immunology, 210, 1, pp. 53-67
Clinical and experimental immunology, 210(1), 53-67. Wiley-Blackwell

Contains fulltext : 286870.pdf (Publisher’s version ) (Open Access) Previous studies have shown that monocytes can be 'trained' or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e032ee4968045dc81e64eb0335e2da9
https://doi.org/10.1093/cei/uxac073

Progressive Control of Streptococcus agalactiae-Induced Innate Inflammatory Response Is Associated with Time Course Expression of MicroRNA-223 by Neutrophils

Autor: Georges Casimir, Maud Deny, Marta Romano, Olivier Denis, Mustapha Chamekh

Publikováno v: Infection and immunity, 88 (12
Infect Immun

Group B streptococcus (GBS) is a human-pathogenic bacterium inducing a strong inflammatory response that may be detrimental for host tissues if not finely regulated. The inflammatory response can be modulated by different molecular mechanisms, among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497d47715aae5e5f3127dfeabce4eb56
https://doi.org/10.1128/iai.00563-20

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5

Autor: Manija A. Kazmi, Mizuho Horioka, Thomas Huber, Jennifer C. Peeler, He Tian, Thomas P. Sakmar, Alexandre Fürstenberg, Oliver Hartley, Yamina A. Berchiche, Carlos A. Rico, Hubert François Gaertner, Emily Lorenzen

Publikováno v: Biophys J
Biophysical Journal, Vol. 117, No 5 (2019) pp. 903-919

The chemokine receptor CCR5 is a drug target to prevent transmission of HIV/AIDS. We studied four analogs of the native chemokine regulated, on activation, normal T-cell-expressed, and secreted (RANTES) (CCL5) that have anti-HIV potencies of around 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225a811adaa90ff9447737bb91556beb
https://pubmed.ncbi.nlm.nih.gov/31421836