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pro vyhledávání: '"Chemokine CCL5/analogs & derivatives/genetics/pharmacology"'
Autor:
Robin E. Offord, Oliver Hartley, Anouk Heimann, Karim Dorgham, Danielle Perez-Bercoff, Fabrice Cerini, Guy Gorochov, Hubert François Gaertner, Gianfranco Pancino, Patrice Debré
Publikováno v:
Journal of Virology, Vol. 77, No 12 (2003) pp. 6637-44
The chemokine receptors CCR5 and CXCR4 are promising non-virus-encoded targets for human immunodeficiency virus (HIV) therapy. We describe a selection procedure to isolate mutant forms of RANTES (CCL5) with antiviral activity considerably in excess o