Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chemokine CCL5/analogs '
Autor:
Robin E. Offord, Oliver Hartley, Anouk Heimann, Karim Dorgham, Danielle Perez-Bercoff, Fabrice Cerini, Guy Gorochov, Hubert François Gaertner, Gianfranco Pancino, Patrice Debré
Publikováno v:
Journal of Virology, Vol. 77, No 12 (2003) pp. 6637-44
The chemokine receptors CCR5 and CXCR4 are promising non-virus-encoded targets for human immunodeficiency virus (HIV) therapy. We describe a selection procedure to isolate mutant forms of RANTES (CCL5) with antiviral activity considerably in excess o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2250862acf88e88536139b9e90535d4
https://doi.org/10.1128/jvi.77.12.6637-6644.2003
https://doi.org/10.1128/jvi.77.12.6637-6644.2003
Autor:
Olivier Chaloin, Robin E. Offord, Donald E. Mosier, Rebecca Sabbe, Oliver Hartley, Cristina Pastore, Gaston Picchio
Publikováno v:
Journal of Virology, Vol. 75, No 2 (2001) pp. 661-71
N-terminal modifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunodeficiency virus type 1 (HIV-1) infection with greater efficacy than native RANTES. Modified RANTES compounds induce rapid CCR5 internaliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad04cb1c723e39ae16e15a4b59a1a60b
https://doi.org/10.1128/jvi.75.2.661-671.2001
https://doi.org/10.1128/jvi.75.2.661-671.2001
Autor:
Robin E. Offord, Oliver Hartley
Publikováno v:
Current Protein & Peptide Science, Vol. 6, No 3 (2005) pp. 207-19
Since the discovery that to enter target cells HIV uses receptors for the class of proteins known as chemokines, attempts have been made to generate anti-HIV molecules based on the chemokine ligands. A significant level of knowledge of the structure-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b91e8605ccb91a7ba84287a1bb9da5
https://archive-ouverte.unige.ch/unige:27011
https://archive-ouverte.unige.ch/unige:27011
Autor:
Laurence Kessler, Christian Toso, Michel Pinget, Pascal Alain Robert Bucher, Alain Bohbot, K. Mandes, Séverine Sigrist, Jose Oberholzer, Roger Lamartine, Guy Esposito
Publikováno v:
Immunology, Vol. 111, No 4 (2004) pp. 416-21
During transplantation, pancreatic islets release chemokines which promote macrophage attraction, hampering engraftment of islets. The aim of this study was to modulate chemotaxis and the immune response of human macrophages induced by islets. Human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50064b7fcea48465498f23f8ee6a4fe7
https://doi.org/10.1111/j.1365-2567.2004.01828.x
https://doi.org/10.1111/j.1365-2567.2004.01828.x
Autor:
Jill Wilken, Robin E. Offord, Marc Alizon, Laurent Picard, Donald E. Mosier, Alejandra Ramos, Fabrice Cerini, Darren A. Thompson, Cristina Pastore, Nikolaus Heveker, Astrid Melotti, Brigitte Dufour, Oliver Hartley, Stephen J. Kent, Richard J. Fish, Hubert François Gaertner
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 101, No 47 (2004) pp. 16460-5
We have used total chemical synthesis to perform high-resolution dissection of the pharmacophore of a potent anti-HIV protein, the aminooxypentane oxime of [glyoxylyl 1 ]RANTES(2-68), known as AOP–RANTES, of which we designed and made 37 analogs. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15c6f120f7a45a6ec3c7f0b29c2a845
https://doi.org/10.1073/pnas.0404802101
https://doi.org/10.1073/pnas.0404802101
Publikováno v:
Journal of Investigative Dermatology, Vol. 127, No 6 (2007) pp. 1436-43
Development of topical microbicides that prevent sexual transmission of HIV is an active area of investigation. The purpose of this study was to test the ability of the potent membrane fusion inhibitor C34, an HIV gp41 antagonist, to block HIV infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d365d423ff573015074a7598ff081754
https://doi.org/10.1038/sj.jid.5700736
https://doi.org/10.1038/sj.jid.5700736
Publikováno v:
Journal of Leukocyte Biology, Vol. 80, No 6 (2006) pp. 1395-404
N-terminal proteolytic processing modulates the biological activity and receptor specificity of RANTES/CCL5. Previously, we showed that an unidentified protease associated with monocytes and neutrophils digests RANTES into a variant lacking three N-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662608cb6e74b4baec80eb814ba06194
https://pubmed.ncbi.nlm.nih.gov/16963625
https://pubmed.ncbi.nlm.nih.gov/16963625
Autor:
Eric J. Arts, Andre J. Marozsan, Vincent S. Torre, Oliver Hartley, Jamie L. Albright, Kalonji R. Collins, Miguel E. Quiñones-Mateu, Robin E. Offord
Publikováno v:
Journal of Virology, Vol. 74, No 10 (2000) pp. 4868-76
Aminooxypentane (AOP)-RANTES efficiently and specifically blocks entry of non-syncytium-inducing (NSI), CCR5-tropic (R5) human immunodeficiency virus type 1 (HIV-1) into host cells. Inhibition appears to be mediated by increased intracellular retenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87a0ebc60f292826fc1c032097a669a
https://archive-ouverte.unige.ch/unige:26085
https://archive-ouverte.unige.ch/unige:26085
Autor:
Tatsuyoshi, Kawamura, Shannon E, Bruse, Awet, Abraha, Makoto, Sugaya, Oliver, Hartley, Robin E, Offord, Eric J, Arts, Peter A, Zimmerman, Andrew, Blauvelt, Shannon E, Bruce
Publikováno v:
Journal of Virology, Vol. 78, No 14 (2004) pp. 7602-9
Topical microbicides that effectively block interactions between CCR5 + immature Langerhans cells (LC) residing within genital epithelia and R5 human immunodeficiency virus (HIV) may decrease sexual transmission of HIV. Here, we investigated the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c43211c70c2da1d3b6e660205b3fa9b
https://pubmed.ncbi.nlm.nih.gov/15220435
https://pubmed.ncbi.nlm.nih.gov/15220435