Zobrazeno 1 - 10
of 584
pro vyhledávání: '"Chemogenetic"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 12, Pp 5249-5266 (2024)
Spinal microglia and astrocytes are both involved in neuropathic and inflammatory pain, which may display sexual dimorphism. Here, we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived interleukin (IL)-17A promotes t
Externí odkaz:
https://doaj.org/article/fae11f272a9f4e009a22c8632b8c69f4
Autor:
Jianbang Lin, Jing Liu, Qi Zhang, Taian Liu, Zexuan Hong, Yi Lu, Cheng Zhong, Zhonghua Lu, Yuantao Li, Yu Hu
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated the
Externí odkaz:
https://doaj.org/article/0cad844d461341f0a6f45915b5d96f24
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 24 (2024)
Background Although there has been limited research into the perturbation of electrophysiological activity in the brain after ischemia, the activity signatures during ischemia and reperfusion remain to be fully elucidated. We aim to comprehensively d
Externí odkaz:
https://doaj.org/article/8c083c733e9645188b6ed689263f3a1e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionThe pedunculopontine nucleus (PPN) plays a role in coordinating complex behaviors and adapting to changing environmental conditions. The specific role of cholinergic neurons in PPN function is not well understood, but their ascending conn
Externí odkaz:
https://doaj.org/article/792051e5110a474690d72ab9ba5c5779
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 289, Iss , Pp 117392- (2025)
The T-2 toxin is a frequent contaminant in the global environment and agricultural production. Existing evidence suggests that the ingested T-2 toxin can enter the brain and exhibit neurotoxicity. However, it is still unknown whether T-2 toxin causes
Externí odkaz:
https://doaj.org/article/bbfc6901a8b744128093372c33c36539
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Diabetic peripheral neuropathy (DPN), a complication of diabetes mellitus (DM), is a neurodegenerative disorder that results from hyperglycemic damage and deficient insulin receptor (IR) signaling in peripheral nerves, triggered by failure of insulin
Externí odkaz:
https://doaj.org/article/080408747ada45109e473f9908b381cd
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThe part played by oxytocin and oxytocin neurons in the regulation of food intake is controversial. There is much pharmacological data to support a role for oxytocin notably in regulating sugar consumption, however, several recent experimen
Externí odkaz:
https://doaj.org/article/d73b59f917324898bdc31ff58256e0b4
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionThe cingulate cortex, with its subregions ACC, MCC, and RSC, is key in pain processing. However, the detailed interactions among these regions in modulating pain sensation have remained unclear.MethodsIn this study, chemogenetic tools wer
Externí odkaz:
https://doaj.org/article/d21e8a15c0f64003b78ecebb50f968a5
Autor:
Di Re, Jessica a, b, Koff, Leandra a, Avchalumov, Yosef a, 1, Singh, Aditya K. a, Baumgartner, Timothy J. a, Marosi, Mate a, 2, Matz, Lisa M. c, Hallberg, Lance M. a, d, Ameredes, Bill T. a, d, Seeley, Erin H. e, Buffington, Shelly A. c, f, Green, Thomas A. a, Laezza, Fernanda a, c, ⁎
Publikováno v:
In Journal of Hazardous Materials 5 March 2025 485
Autor:
Feng Chen, Xi Dong, Zhenhuan Wang, Tongrui Wu, Liangpeng Wei, Yuanyuan Li, Kai Zhang, Zengguang Ma, Chao Tian, Jing Li, Jingyu Zhao, Wei Zhang, Aili Liu, Hui Shen
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 425-433 (2024)
Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory, resistant to antiepileptic drugs, and has a high recurrence rate. The pathogenesis of temporal lobe epilepsy is complex and is not fully understood. Intr
Externí odkaz:
https://doaj.org/article/c8d0f2f8c5474ae79913db668afb65da