Nrf2/Keap1-Pathway Activation and Reduced Susceptibility to Chemotherapy Treatment by Acidification in Esophageal Adenocarcinoma Cells

Autor: Storz, Lucie, Walther, Philipp, Chemnitzer, Olga, Lyros, Orestis, Niebisch, Stefan, Mehdorn, Matthias, Jansen-Winkeln, Boris, Moulla, Yusef, Büch, Thomas, Gockel, Ines, Thieme, René

Chronic acid reflux causes cellular damage and inflammation in the lower esophagus. Due to these irritating insults, the squamous epithelium is replaced by metaplastic epithelium, which is a risk factor for the development of esophageal adenocarcinom

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In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence.

Autor: Götzel, Katharina¹ katharina.goetzel@medizin.uni-leipzig.de, Chemnitzer, Olga¹ olga.chemnitzer@medizin.uni-leipzig.de, Maurer, Luisa¹ luisa.maurer@medizin.uni-leipzig.de, Dietrich, Arne^1,2 arne.dietrich@medizin.uni-leipzig.de, Eichfeld, Uwe¹ uwe.eichfeld@medizin.uni-leipzig.de, Lyros, Orestis¹ orestis.lyros@medizin.uni-leipzig.de, Moulla, Yusef¹ yusef.moulla@medizin.uni-leipzig.de, Niebisch, Stefan¹ stefan.niebisch@medizin.uni-leipzig.de, Mehdorn, Matthias¹ matthias.mehdorn@medizin.uni-leipzig.de, Jansen-Winkeln, Boris¹ boris.jansen-winkeln@medizin.uni-leipzig.de, Vieth, Michael³ michael.vieth@uni-bayreuth.de, Hoffmeister, Albrecht⁴ albrecht.hoffmeister@medizin.uni-leipzig.de, Gockel, Ines¹ ines.gockel@medizin.uni-leipzig.de, Thieme, René¹ rene.thieme@medizin.uni-leipzig.de

Publikováno v: BMC Gastroenterology. 3/6/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p. 1 Diagram, 2 Charts, 6 Graphs.

Nrf2/Keap1-Pathway Activation and Reduced Susceptibility to Chemotherapy Treatment by Acidification in Esophageal Adenocarcinoma Cells.

Autor: Storz L; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Walther P; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Chemnitzer O; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Lyros O; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Niebisch S; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Mehdorn M; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Jansen-Winkeln B; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Moulla Y; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Büch T; Medical Faculty, Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, Haertelstrasse 16-18, 04103 Leipzig, Germany., Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany., Thieme R; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2021 Jun 04; Vol. 13 (11). Date of Electronic Publication: 2021 Jun 04.