Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

Autor: Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach

Publikováno v: eLife, Vol 11 (2022)

Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing

Externí odkaz: https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0

Comparative and integrative analysis of RNA structural profiling data: current practices and emerging questions

Autor: Krishna Choudhary, Fei Deng, Sharon Aviran

Publikováno v: Quantitative biology (Beijing, China), vol 5, iss 1
Choudhary, K; Deng, F; & Aviran, S. (2017). Comparative and integrative analysis of RNA structural profiling data: current practices and emerging questions. Quantitative Biology, 5(1), 3-24. doi: 10.1007/s40484-017-0093-6. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2qv8q11r

© 2017, Higher Education Press and Springer-Verlag GmbH. Background: Structure profiling experiments provide single-nucleotide information on RNA structure. Recent advances in chemistry combined with application of high-throughput sequencing have en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fbcb46d391212ec97002c7225e2906
https://escholarship.org/uc/item/2qv8q11r

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