Zobrazeno 1 - 10 of 327 pro vyhledávání: '"Chemical and physical biology [NCMLS 7]"'
1
Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions
Autor: Herman G.P. Swarts, Karl M. Weigand, Hanka Venselaar, Frans G. M. Russel, Jan B. Koenderink, Arn M. J. M. van den Maagdenberg
Publikováno v: BBA-Molecular Basis of Disease, 1832(12), 2173-2179
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1832, 2173-9
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1832, 12, pp. 2173-9
Contains fulltext : 125451.pdf (Publisher’s version ) (Closed access) Familial hemiplegic migraine (FHM) is a monogenic variant of migraine with aura. One of the three known causative genes, ATP1A2, which encodes the alpha2 isoform of Na,K-ATPase,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6596b8ae75c86009472250298cfbb565
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2
Intellectual disability and bleeding diathesis due to deficient CMP-sialic acid transport
Autor: Arjan P.M. de Brouwer, Angel Ashikov, Rita Gerardy-Schahn, Samuel Schmidt, Joris H. Robben, Miski Mohamed, Maïlys Guillard, Ron A. Wevers, B. van den Heuvel, Peter M.T. Deen, Eva Morava, Dirk Lefeber
Publikováno v: Neurology, 81, 7, pp. 681-7
Neurology, 81, 681-7
Contains fulltext : 119120.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To identify the underlying genetic defect in a patient with intellectual disability, seizures, ataxia, macrothrombocytopenia, renal and cardiac involvement, and abnorm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd2210be2243f322d3a0fb594dd4238
https://doi.org/10.1212/wnl.0b013e3182a08f53
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3
Molecular Parameters of siRNA–Cell Penetrating Peptide Nanocomplexes for Efficient Cellular Delivery
Autor: Petra H. M. Bovee-Geurts, Staffan Lindberg, Andrea Beyerle, Roland Brock, Olaf Heidenreich, Mattias Hällbrink, Hesta McNeill, Alexander Henrik Baron Van Asbeck, Ülo Langel, Wouter P. R. Verdurmen
Publikováno v: ACS Nano, 7, 5, pp. 3797-807
ACS Nano, 7, 3797-807
Item does not contain fulltext Cell-penetrating peptides (CPPs) are versatile tools for the intracellular delivery of various biomolecules, including siRNA. Recently, CPPs were introduced that showed greatly enhanced delivery efficiency. However, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2713e7fc09713058a8de0873bc8f135a
https://doi.org/10.1021/nn305754c
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5
Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs
Autor: Schuurman, W., Levett, P.A., Pot, M.W., Weeren, P.R. van, Dhert, W.J., Hutmacher, D.W., Melchels, F.P., Klein, T.J., Malda, J.
Publikováno v: Macromolecular Bioscience, 13, 551-61
Macromolecular Bioscience, 13, 5, pp. 551-61
Item does not contain fulltext Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, U
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::67a165f31ed0ceb14175acfb1f4d26ac
https://hdl.handle.net/2066/118468
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6
High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization
Autor: Philipp C. Kohler, Andreas Heine, Tina Ritschel, Luzi Jakob Barandun, Gerhard Klebe, F. Immekus, Pierfrancesco Orlando, François Diederich
Publikováno v: Acta Crystallographica Section D-Biological Crystallography, 69, Pt 9, pp. 1798-807
Acta Crystallographica Section D-Biological Crystallography, 69, 1798-807
The tRNA-modifying enzyme tRNA–guanine transglycosyl­ase (TGT) has been recognized as a drug target for the treatment of the foodborne illness shigellosis. The active site of TGT consists of three pockets: the central guanine/preQ1 recognition sit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d6e708107942022fbcf0ded5479492
https://doi.org/10.1107/s0907444913014509
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7
The development of the depletion zone during ceiling crystallization: phase shifting interferometry and simulation results
Autor: Willem J. de Grip, Elias Vlieg, Alaa Adawy, Willem J. P. van Enckevort, Kess M. Marks
Publikováno v: CrystEngComm, 15, 12, pp. 2275-2286
CrystEngComm, 15 (12), pp. 2275-2286
CrystEngComm, 15, 2275-2286
CrystEngComm, 15 (12), 2275-2286
The growth of high quality protein crystals is essential for the determination of their structure. This process is governed by many physical factors such as mass transport and solution flow. The quality of the crystals is usually better under diffusi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9945ffcfaf8d29635fec4b07cb044ed7
https://hdl.handle.net/2066/111445
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8
A time-motion study of inpatient rounds using a family-centered rounds model
Autor: Bhansali, P., Birch, S., Campbell, J.K., Agrawal, D., Hoffner, W., Manicone, P., Shah, K., Krieger, E., Ottolini, M.
Publikováno v: Hospital Pediatrics, 3, 31-8
Hospital Pediatrics, 3, 1, pp. 31-8
Item does not contain fulltext OBJECTIVE: Family-centered rounds (FCR) have become increasingly prevalent in pediatric hospital settings. The objective of our study was to describe time use and discrete events during pediatric inpatient rounds by usi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bc604ef555ebf5794aee95375326a78f
https://hdl.handle.net/2066/125190
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9
Structural model of a putrescine-cadaverine permease from Trypanosoma cruzi predicts residues vital for transport and ligand binding
Autor: Jacqueline N. Poston, Buddy Ullman, Hanka Venselaar, Radika Soysa, Marie Pierre Hasne
Publikováno v: Biochemical Journal, 452, 423-32
Biochemical Journal, 452, 3, pp. 423-32
Contains fulltext : 117693.pdf (Publisher’s version ) (Closed access) The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046303463e1def2e4c8019124f7bea3e
https://hdl.handle.net/2066/117693
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10
Consensus engineering of sucrose phosphorylase: The outcome reflects the sequence input
Autor: Aerts, D., Verhaeghe, T., Joosten, H.J., Vriend, G., Soetaert, W., Desmet, T.
Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, 110, 10, pp. 2563-72
Biotechnology and Bioengineering, 110, 2563-72
Item does not contain fulltext Consensus engineering, which is replacing amino acids by the most frequently occurring one at their positions in a multiple sequence alignment (MSA), is a known strategy to increase the stability of a protein. The appli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cbba24b535b3e99f3618c7516dc5b7f1
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