Zobrazeno 1 - 10
of 1 002
pro vyhledávání: '"Chemical Screening"'
Autor:
Fabian G. Weichert, Werner Brack, Mario Brauns, Patrick Fink, Sarah Johann, Martin Krauss, Henner Hollert
Publikováno v:
Data in Brief, Vol 54, Iss , Pp 110510- (2024)
Chemical pollution of the aquatic environment is nowadays characterised by increasing levels of anthropogenic organic compounds at low concentrations and is recognised as one of the main drivers of the deteriorated ecological state of European waterb
Externí odkaz:
https://doaj.org/article/13dbcdce088948d78620c14a654027bf
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chronological lifespan in human cell
Externí odkaz:
https://doaj.org/article/e6061c31863549b8ad5d29645c27f527
Autor:
Seojung Kim, Tae-Houn Kim
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1177 (2024)
Abiotic stresses, such as drought, salinity, and extreme temperatures, limit plant growth and development, reducing crop yields. Therefore, a more comprehensive understanding of the signaling mechanisms and responses of plants to changing environment
Externí odkaz:
https://doaj.org/article/82d6fab31f4444089cd64b108df78bec
Autor:
Victor Castañeda-Monsalve, Laura-Fabienne Fröhlich, Sven-Bastiaan Haange, Masun Nabhan Homsi, Ulrike Rolle-Kampczyk, Qiuguo Fu, Martin von Bergen, Nico Jehmlich
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
The human gut microbiota is a complex microbial community with critical functions for the host, including the transformation of various chemicals. While effects on microorganisms has been evaluated using single-species models, their functional effect
Externí odkaz:
https://doaj.org/article/08060df93b5e4e12b5a3f9a9e89cae6a
Autor:
Yuanyuan Chen, Jianyong Du, Lixia Zheng, Zihao Wang, Zongwang Zhang, Zhengyuan Wu, Xiaojun Zhu, Jing-Wei Xiong
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-11 (2023)
Abstract Ischemia–reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are incompletely understood and effective pharmacological interventions are limited. Here, we re
Externí odkaz:
https://doaj.org/article/09f0cdff8dc24290a3ff1a81803fa4be
Akademický článek
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Autor:
SHA Wu-ga, LI Jun
Publikováno v:
Jichu yixue yu linchuang, Vol 42, Iss 6, Pp 933-939 (2022)
Objective To find new drug candidates for cancer treatment by screening inhibitors of NMNAT1 using recombinant human NMNAT1 expressed in E. coli system. Methods The human NMNAT1 was inserted into the pET21b(+) vector and the recombinant plasmid was t
Externí odkaz:
https://doaj.org/article/dc3945df34bb4c978258b6a588187568
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp 1-16 (2022)
Abstract Chemical probes are important tools for understanding biological systems. However, because of the huge combinatorial space of targets and potential compounds, traditional chemical screens cannot be applied systematically to find probes for a
Externí odkaz:
https://doaj.org/article/41608ba3e1db41e0a62b3498c5b44008
Autor:
John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/e9522fc36290440fb2985f54b8531064
Autor:
Voula Mitsakos
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e14304- (2023)
In search of a new class of antibacterial agents, compounds that target the essential bacterial enzyme, dihydrodipicolinate synthase (DHDPS), are of interest to drug discovery efforts. DHDPS catalyzes the first committed step in the diaminopimelate (
Externí odkaz:
https://doaj.org/article/13b2fddf9d334ff2bff5955add7273d1