Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain

Autor: Sophy Charlton, Selina Brace, Mateja Hajdinjak, Rebecca Kearney, Thomas Booth, Hazel Reade, Jennifer A. Tripp, Kerry L. Sayle, Sonja B. Grimm, Silvia M. Bello, Elizabeth A. Walker, Alexandre Gilardet, Philip East, Isabelle Glocke, Greger Larson, Tom Higham, Chris Stringer, Pontus Skoglund, Ian Barnes, Rhiannon E. Stevens

Publikováno v: Nature Ecology & Evolution

Genetic investigations of Upper Palaeolithic Europe have revealed a complex and transformative history of human population movements and ancestries, with evidence of several instances of genetic change across the European continent in the period foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0a868f5bb2509e4a33c474714881b8
https://doi.org/10.1038/s41559-022-01883-z

Affinity-enhanced RNA-binding domains as tools to understand RNA recognition

Autor: Chaves-Arquero, Belén, Collins, Katherine M, Abis, Giancarlo, Kelly, Geoff, Christodoulou, Evangelos, Taylor, Ian A, Ramos, Andres

13 p.-4 fig.-1 graph. abst.
Understanding how the RNA-binding domains of a protein regulator are used to recognize its RNA targets is a key problem in RNA biology, but RNA-binding domains with very low affinity do not perform well in the methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e56f8eba52ff3731b6c95c0e2ee1dc9
http://hdl.handle.net/10261/330033

Solvent Precipitation SP3 (SP4) Enhances Recovery for Proteomics Sample Preparation without Magnetic Beads

Autor: Harvey E. Johnston, Kranthikumar Yadav, Joanna M. Kirkpatrick, George S. Biggs, David Oxley, Holger B. Kramer, Rahul S. Samant

Publikováno v: Analytical Chemistry. 94:10320-10328

Complete, reproducible extraction of protein material is essential for comprehensive and unbiased proteome analyses. A current gold standard is single-pot, solid-phase-enhanced sample preparation (SP3), in which organic solvent and magnetic beads are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1030fcdeef7a177cfeb30b13c0b702
https://doi.org/10.1021/acs.analchem.1c04200

Speaking the host language: how Salmonella effector proteins manipulate the host

Autor: Pillay, Timesh D, Hettiarachchi, Sahampath U, Gan, Jiyao, Diaz-Del-Olmo, Ines, Yu, Xiu-Jun, Muench, Janina H, Thurston, Teresa LM, Pearson, Jaclyn S

Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been described as mediating eukaryotic-like, biochemical post-translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02b3c5b37657fe150f25384ffc1009d
http://hdl.handle.net/10044/1/105083

The proteomic landscape of genome-wide genetic perturbations

Autor: Christoph B. Messner, Vadim Demichev, Julia Muenzner, Simran K. Aulakh, Natalie Barthel, Annika Röhl, Lucía Herrera-Domínguez, Anna-Sophia Egger, Stephan Kamrad, Jing Hou, Guihong Tan, Oliver Lemke, Enrica Calvani, Lukasz Szyrwiel, Michael Mülleder, Kathryn S. Lilley, Charles Boone, Georg Kustatscher, Markus Ralser

Publikováno v: Cell
Messner, C B, Demichev, V, Muenzner, J, Aulakh, S K, Barthel, N, Röhl, A, Herrera-Domínguez, L, Egger, A, Kamrad, S, Hou, J, Tan, G, Lemke, O, Calvani, E, Szyrwiel, L, Mülleder, M, Lilley, K S, Boone, C, Kustatscher, G & Ralser, M 2023, ' The proteomic landscape of genome-wide genetic perturbations ', Cell, vol. 186, no. 9 . https://doi.org/10.1016/j.cell.2023.03.026

Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2d60b8045d42b55731221ebbf452f9
https://hdl.handle.net/21.11116/0000-000D-2B00-321.11116/0000-000D-2B02-1