Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Chemical Biology/Chemical Biology of the Cell"'
Autor:
K J Lavender, Liu Mkp., Andrew J. McMichael, A R Stacey, Alison Simmons, N Gasper-Smith, Persephone Borrow, K di Gleria, Holger B. Kramer, Li Qin, Barton F. Haynes, Benedikt M. Kessler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000893 (2010)
PLoS Pathogens
PLoS Pathogens
The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During this time frame, components of the innate immune system such as macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8668e9ce71bc84fc61956b4c09ff5294
https://ora.ox.ac.uk/objects/uuid:3b3c1629-af02-4fa1-9549-b98430072284
https://ora.ox.ac.uk/objects/uuid:3b3c1629-af02-4fa1-9549-b98430072284
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14575 (2011)
PLoS ONE, Vol 6, Iss 1, p e14575 (2011)
Glutamate excitotoxicity is one of the major events that takes place during various neurotoxic injuries such as brain ischemia. We prepared grape seed extracts, from two different varieties, containing high amounts of polyphenols but little resveratr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc4257507ba4efecb5a964083213a49
http://europepmc.org/articles/PMC3025924
http://europepmc.org/articles/PMC3025924
A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
Autor:
Thomas J. Begley, Clement T Y Chan, Koli Taghizadeh, Michael S. DeMott, Madhu Dyavaiah, Peter C. Dedon
Publikováno v:
PLoS Genetics
PLoS
PLoS Genetics, Vol 6, Iss 12, p e1001247 (2010)
PLoS
PLoS Genetics, Vol 6, Iss 12, p e1001247 (2010)
Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b94db48ef5e639862c63195f672d82
http://europepmc.org/articles/PMC3002981
http://europepmc.org/articles/PMC3002981
Autor:
Thibault Mayor, Maria Brack, Esther A. Gies, Carolina Arias Novoa, Poul H. Sorensen, Inga B. Wilde, Aruna D. Balgi, Barak Rotblat, Jason M. Winget, Michel Roberge
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 12, p e14410 (2010)
PLoS ONE, Vol 5, Iss 12, p e14410 (2010)
Background Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ddc95d076004cbf43b53b697682ef9
http://europepmc.org/articles/PMC3009716
http://europepmc.org/articles/PMC3009716
Autor:
David A Knecht, Rebecca A LaFleur, Alem W Kahsai, Christian E Argueta, Anwar B Beshir, Gabriel Fenteany
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14039 (2010)
PLoS ONE
PLoS ONE
Background Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism. They are also known to cause changes in the organizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b166eca770d129eac52114598d3c9e1
http://europepmc.org/articles/PMC2991314?pdf=render
http://europepmc.org/articles/PMC2991314?pdf=render
Publikováno v:
PLoS genetics, vol 6, iss 11
PLoS Genetics, Vol 6, Iss 11, p e1001198 (2010)
PLoS Genetics
PLoS Genetics, Vol 6, Iss 11, p e1001198 (2010)
PLoS Genetics
Discovering links between the genotype of an organism and its metabolite levels can increase our understanding of metabolism, its controls, and the indirect effects of metabolism on other quantitative traits. Recent technological advances in both DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36cadd7fdf3cea0855667b4425a3094
https://escholarship.org/uc/item/06n307hb
https://escholarship.org/uc/item/06n307hb
Autor:
Yoshihisa Kubota, M. Neal Waxham
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000987 (2010)
PLoS Computational Biology
PLoS Computational Biology
Calmodulin (CaM) is a ubiquitous Ca2+ buffer and second messenger that affects cellular function as diverse as cardiac excitability, synaptic plasticity, and gene transcription. In CA1 pyramidal neurons, CaM regulates two opposing Ca2+-dependent proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d9537920e8bb3f86c5a2d42baab378
http://europepmc.org/articles/PMC2978734?pdf=render
http://europepmc.org/articles/PMC2978734?pdf=render
Autor:
Ihn Han, Ji Hoon Jung, Eun-Ok Lee, Chang-Yan Chen, Sung-Hoon Kim, Seung-Ae Kim, Hyo-Jung Lee, Soo-Jin Jeong, Hyo-Jeong Lee, Shudong Zhu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12358 (2010)
PLoS ONE, Vol 5, Iss 8, p e12358 (2010)
Background We previously reported the anti-angiogenic activity of paeonol isolated from Moutan Cortex. In the present study, we investigated the negative effect of paeonol oxime (PO, a paeonol derivative) on basic fibroblast growth factor (bFGF)-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2c2bcfb261378a3742b08ab8c29c81
http://europepmc.org/articles/PMC2925949
http://europepmc.org/articles/PMC2925949
Autor:
Ernest Hamel, Stefano Santaguida, Romano Silvestri, Peter De Wulf, Tam Luong Nguyen, Andrea Musacchio, Rick Gussio, Emanuela Screpanti
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11603 (2010)
PLoS ONE
PLoS ONE
Background: Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddefef1ddedb919b4c12e4e961d6c58
http://europepmc.org/articles/PMC2904697?pdf=render
http://europepmc.org/articles/PMC2904697?pdf=render
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11104 (2010)
PLoS One, Vol. 5, no. 6 (2010)
PLoS ONE
PLoS One, Vol. 5, no. 6 (2010)
PLoS ONE
Signalling is a key feature of living cells which frequently involves the local clustering of specific proteins in the plasma membrane. How such protein clustering is achieved within membrane microdomains ("rafts") is an important, yet largely unsolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578e387482ebca49270188acbb1fbc20
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20559440/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20559440/?tool=EBI