Platinum-Based Chemotherapy Induces Opposing Effects on Immunotherapy Response-Related Spatial and Stromal Biomarkers in the Bladder Cancer Microenvironment.

Autor: Chelushkin MA; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Dorp J; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., van Wilpe S; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands., Seignette IM; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Mellema JJ; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Alkemade M; Core Facility Molecular Pathology & Biobanking, Netherlands Cancer Institute, Amsterdam, the Netherlands., Gil-Jimenez A; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Peters D; Core Facility Molecular Pathology & Biobanking, Netherlands Cancer Institute, Amsterdam, the Netherlands., Brugman W; Genomics Core Facility, Netherlands Cancer Institute, Amsterdam, the Netherlands., Stockem CF; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Hooijberg E; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Broeks A; Core Facility Molecular Pathology & Biobanking, Netherlands Cancer Institute, Amsterdam, the Netherlands., van Rhijn BWG; Department of Urology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany., Mertens LS; Department of Urology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., van der Heijden AG; Department of Urology, Radboud University Medical Center, Nijmegen, the Netherlands., Mehra N; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands., van Montfoort ML; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Wessels LFA; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, the Netherlands., Vis DJ; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van der Heijden MS; Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Sep 13; Vol. 30 (18), pp. 4227-4239.