Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chelsy R. Eddings"'
Autor:
Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 118-129 (2019)
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the
Externí odkaz:
https://doaj.org/article/6c7c6a1004604c76b60f2b97bd104cc6
Autor:
Chelsy R Eddings, Ernest Fraenkel, Mali Jiang, C. Conover Talbot, Paul T. Ranum, Lauren R. DeVine, Robert N. Cole, Emma Whelan, Anthony Tang, Amanda J. Kedaigle, Leonard O Marque, Beverly L. Davidson, Ronald Wang, Nicolas Arbez, Tamara Ratovitski, Christopher A. Ross, Sergey S Akimov
Publikováno v:
Prof. Fraenkel
Hum Mol Genet
Hum Mol Genet
We have previously established induced pluripotent stem cell (iPSC) models of Huntington’s disease (HD), demonstrating CAG-repeat-expansion-dependent cell biological changes and toxicity. However, the current differentiation protocols are cumbersom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1865400d87031d19ad0d1a4727da4586
https://doi.org/10.1093/hmg/ddab200
https://doi.org/10.1093/hmg/ddab200
Autor:
Mark Ren, Elaine Roby, Christopher A. Ross, Sergey S Akimov, Xiaofang Wang, Nicolas Arbez, Chelsy R Eddings
Publikováno v:
Journal of Huntington's Disease. 8:129-143
Background The potential benefit of cysteamine for Huntington's disease has been demonstrated in HD animal models. Cysteamine and its derivate cystamine were shown to reduce neuropathology and prolong lifespan. Human studies have demonstrated safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7cab0912d04ac8bf79b6ff219d1c21f
https://doi.org/10.3233/jhd-180312
https://doi.org/10.3233/jhd-180312
Autor:
Ni Arbez, Chelsy R Eddings, Mark Ren, Christopher A. Ross, Elaine Roby, Sergey S Akimov, Xiaofang Wang
Publikováno v:
Journal of Huntington's disease. 9(3)
BACKGROUND: The potential benefit of cysteamine for Huntington’s disease has been demonstrated in HD animal models. Cysteamine and its derivate cystamine were shown to reduce neuropathology and prolong lifespan. Human studies have demonstrated safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1179e149a8b5216ca1cf37f5855be6b2
https://pubmed.ncbi.nlm.nih.gov/30856117
https://pubmed.ncbi.nlm.nih.gov/30856117
Autor:
Andrew Dillin, Yishuo Shen, Helen V. Harrison, Albert J. Becker, Chelsy R. Eddings, Marcela K. Preininger, Gregory Chin, Jonathan Ofer, Rishi Patel, Hana Ghanim, Naznin Jahan, Harrison J. Ramsay, Ariana Moghbel, Alon Friedman, Adiel Charbash, Dan Z. Milikovsky, Barry Hart, Vladimir V. Senatorov, Eszter Mihaly, Daniela Kaufer, Rotem Saar-Ashkenazy, Jessica M. Lin, Michael A. Rogawski, Peter H. Sudmant, Aaron R. Friedman, Ronel Veksler, Huanjie Sheng
Publikováno v:
Science Translational Medicine. 11
Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying the transition from a young-and-healthy to aged-and-dysfunctional brain are not well understood. Here, we report brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce63f38a6ea6d200d935cbdb7c2ba5eb
https://doi.org/10.1126/scitranslmed.aaw8283
https://doi.org/10.1126/scitranslmed.aaw8283
Publikováno v:
Exp Biol Med (Maywood)
Sigma-1 receptor (Sigma1R; SIGMAR1), an integral membrane protein of the endoplasmic reticulum and nuclear envelope, has a hydrophobic drug-binding pocket that binds with high affinity to addictive drugs (cocaine, methamphetamine) and therapeutics us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c279264c2bba991d11cb29a7533569a
https://pubmed.ncbi.nlm.nih.gov/31324122
https://pubmed.ncbi.nlm.nih.gov/31324122