Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine

Autor: Fyke, Zach, Johansson, Rachel, Scott, Anna I., Wiley, Devin, Chelsky, Daniel, Zak, Joseph D., Al Nakouzi, Nader, Koster, Kevin P., Yoshii, Akira

Publikováno v: In Molecular Genetics and Metabolism September-October 2024 143(1-2)

Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry

Autor: McMillan, Kirk, Adler, Marc, Auld, Douglas S., Baldwin, John J., Blasko, Eric, Browne, Leslie J., Chelsky, Daniel, Davey, David, Dolle, Ronald E., Eagen, Keith A., Erickson, Shawn, Feldman, Richard I., Glaser, Charles B., Mallari, Cornell, Morrissey, Michael M., Pan, Gonghua, Parkinson, John F., Phillips, Gary B., Polokoff, Mark A., Sigal, Nolan H., Vergona, Ronald, Whitlow, Marc, Young, Tish A., Devlin, James J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2000 Feb . 97(4), 1506-1511.

Externí odkaz: https://www.jstor.org/stable/121504

Preclinical and clinical biomarker studies of CT181:a novel approach to Alzheimer’s disease modification

Autor: Izzo, Nicholas J, Yuede, Carla M, LaBarbera, Kelsie M, Limegrover, Colleen S, Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E, Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M, Davis, Chuck, Grundman, Michael, Schneider, Lon S, DeKosky, Steven T, Chelsky, Daniel, Pike, Ian, Henstridge, Christopherf, Blennow, Kaj, Zetterberg, Henrik, LeVine III, Harry, Spires-Jones, Tara, Cirrito, John R, Catalano, Susan M

Publikováno v: Izzo, N J, Yuede, C M, LaBarbera, K M, Limegrover, C S, Rehak, C, Yurko, R, Waybright, L, Look, G, Rishton, G, Safferstein, H, Hamby, M E, Williams, C, Sadlek, K, Edwards, H M, Davis, C, Grundman, M, Schneider, L S, DeKosky, S T, Chelsky, D, Pike, I, Henstridge, C, Blennow, K, Zetterberg, H, LeVine III, H, Spires-Jones, T, Cirrito, J R & Catalano, S M 2021, ' Preclinical and clinical biomarker studies of CT181 : a novel approach to Alzheimer’s disease modification ', Alzheimer's & Dementia, vol. 17, no. 8, pp. 1365-1382 . https://doi.org/10.1002/alz.12302

IntroductionAmyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory failure as they build up in Alzheimer's disease (AD) patients’ brain tissue. We previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::243995071df0461b2356d2d354b8f048
https://www.pure.ed.ac.uk/ws/files/297197886/Alzheimer_s_Dementia_2021_Izzo_Preclinical_and_clinical_biomarker_studies_of_CT1812_A_novel_approach_to_Alzheimer.pdf

Structural Studies of Methyl-Accepting Chemotaxis Proteins of Escherichia coli: Evidence for Multiple Methylation Sites

Autor: Chelsky, Daniel, Dahlquist, F. W.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1980 May 01. 77(5), 2434-2438.

Externí odkaz: https://www.jstor.org/stable/8703

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