Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Chelsia Qiuxia Wang"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological malignancies in recent years. Conventional αβ T cells applied in these t
Externí odkaz:
https://doaj.org/article/69472357978f47b8999c2bb0edaf4ee0
Autor:
Chelsia Qiuxia Wang, Fong Chan Choy, Arleen Sanny, Takashi Murakami, Andy Hee-Meng Tan, Kong-Peng Lam
Publikováno v:
Cells, Vol 12, Iss 2, p 309 (2023)
Immune checkpoint blockade (ICB) therapy involves the inhibition of immune checkpoint regulators which reverses their limitation of T cell anti-tumor responses and results in long-lasting tumor regression. However, poor clinical response or tumor rel
Externí odkaz:
https://doaj.org/article/d5bb232d60fc4ffa93cfd7f37cd8e792
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Autor:
Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong-Jae Shin, Do-Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumor
Externí odkaz:
https://doaj.org/article/3e889e3b0c2349c59ada25c89786da9e
Autor:
Chelsia Qiuxia Wang, Vaidehi Krishnan, Lavina Sierra Tay, Desmond Wai Loon Chin, Cai Ping Koh, Jing Yuan Chooi, Giselle Sek Suan Nah, Linsen Du, Bindya Jacob, Namiko Yamashita, Soak Kuan Lai, Tuan Zea Tan, Seiichi Mori, Ichiro Tanuichi, Vinay Tergaonkar, Yoshiaki Ito, Motomi Osato
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 767-782 (2014)
The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;R
Externí odkaz:
https://doaj.org/article/3b353b3acf3041a084d54e3e7b53c5e3
Autor:
Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, Vinay Tergaonkar, Motomi Osato, Philipp Kaldis
Publikováno v:
Haematologica, Vol 100, Iss 4 (2015)
Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts are embryonic lethal due to heart defects, and this precludes the investigation of their overlapping roles in definitive hematopoiesis. Here we use a conditional kn
Externí odkaz:
https://doaj.org/article/926090a93b1f4415806bd2e65b8520b7
Autor:
Chelsia Qiuxia Wang, Andy Hee-Meng Tan
Publikováno v:
Cell and Gene Therapy Insights. 7:1613-1621
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Chelsia Qiuxia Wang, Motomi Osato, Sayed Hamada Madboly, Norio Asou, Kimi Araki, Eisaku Iwanaga, Masao Matsuoka, Naomi Nakagata, Takako Ideue, Kenji Tokunaga, Tomomasa Yokomizo, Mariko Morii, Vania Swee Imm Teoh, Abdellah Abosrie Ali Omar, Takako Yokomizo, Goro Sashida, Akiko Niibori-Nambu, Mohamed Gaber Abdallah, Sho Kubota, Mabrouk Mahmoud Aboelenin, Michelle Meng Huang Mok
Publikováno v:
Leukemia
Autor:
Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang, Tomomasa Yokomizo, Cherry Ee Lin Ng, Linsen Du, Vinay Tergaonkar, Dominic Chih-Cheng Voon, Hiroaki Kitamura, Hiroki Hosoi, Takashi Sonoki, Mok Meng Huang Michelle, Lii Jye Tan, Akiko Niibori-Nambu, Yi Zhang, Archibald S. Perkins, Zakir Hossain, Daniel G. Tenen, Yoshiaki Ito, Byrappa Venkatesh, Motomi Osato
Publikováno v:
Gene. 851:147049
A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducibl
Autor:
Cherry Ee Lin Ng, Daniel G. Tenen, Cai Ping Koh, Takashi Sonoki, Vinay Tergaonkar, Yi Zhang, Archibald S. Perkins, Avinash Govind Bahirvani, Zakir Hossain, Linsen Du, Byrappa Venkatesh, Tomomasa Yokomizo, Chelsia Qiuxia Wang, Akiko Niibori-Nambu, Motomi Osato, Yoshiaki Ito, Hiroki Hosoi, Dominic Chih-Cheng Voon, Michelle Meng Huang Mok
SummaryA cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c73b879a353eafa22afa7a90687302
https://doi.org/10.1101/2021.11.24.469958
https://doi.org/10.1101/2021.11.24.469958